Corrigendum. Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review.

Correction to: European Journal of Clinical Nutrition (2014) 68, 510­516; doi:10.1038/ejcn.2014.7; published online 12 February 2014 Since the publication of this article the authors have noticed an error in the first sentence of the last paragraph of the results section. The sentence should be: In addition, five Mg intervention studies (Table 2) reported on the association between Mg supplementation and serum CRP levels. The authors apologize for any inconvenience caused.

Dietary magnesium intake and risk of metabolic syndrome: a meta-analysis.

AIMS: To estimate quantitatively the association between dietary magnesium intake and risk of metabolic syndrome by combining the relevant published articles using meta-analysis. METHODS: We reviewed the relevant literature in PubMed and EMBASE published up until August 2013 and obtained additional information through Google or a hand search of the references in relevant articles. A random-effects or fixed-effects model, as appropriate, was used to pool the effect sizes on metabolic syndrome comparing individuals with the highest dietary magnesium intake with those having the lowest intake. The dose-response relationship was assessed for every 100-mg/day increment in magnesium intake and risk of metabolic syndrome. RESULT: Six cross-sectional studies, including a total of 24 473 individuals and 6311 cases of metabolic syndrome, were identified as eligible for the meta-analysis. A weighted inverse association was found between dietary magnesium intake and the risk of metabolic syndrome (odds ratio 0.69, 95% CI 0.59, 0.81) comparing the highest with the lowest group. For every 100-mg/day increment in magnesium intake, the overall risk of having metabolic syndrome was lowered by 17% (odds ratio 0.83, 95% CI 0. 77, 0.89). CONCLUSION: Findings from the present meta-analysis suggest that dietary magnesium intake is inversely associated with the prevalence of metabolic syndrome. Further studies, in particular well-designed longitudinal cohort studies and randomized placebo-controlled clinical trials, are warranted to provide solid evidence and to establish causal inference.

Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review.

BACKGROUND/OBJECTIVES: The aim of this study was to quantitatively summarize the association of dietary magnesium (Mg) intake with serum C-reactive protein (CRP) levels in the general population. SUBJECTS/METHODS: Observational and experimental studies through February 2013 were reviewed in PubMed and EMBASE. Additional information was retrieved through Google or hand search of related reference lists. The main outcome is either adjusted geometric mean of CRP or odds ratio (OR) of having serum CRP ≥ 3 mg/l. Meta-regression was used to determine the linear association of dietary Mg intake and adjusted geometric means of CRP levels. A fixed-effects model was used to pool ORs of interest, comparing those in the lowest with those in the highest group of dietary Mg intake. RESULTS: A data set derived from seven cross-sectional studies including 32,918 participants was quantitatively assessed. A weighted inverse association between Mg intake and serum CRP levels was observed (ß-coefficient: -0.0028; 95% confidence interval (CI), -0.0043 to -0.0013; P(trend) = 0.001) from four cross-sectional studies. The pooled OR (95% CI) of having CRP ≥ 3 mg/l was 1.49 (1.18-1.89) on comparing the lowest to the highest group of Mg intake from three studies with the data available. Qualitative assessment among five intervention studies also showed a potential beneficial effect of Mg intake on serum CRP levels. CONCLUSIONS: This meta-analysis and systematic review indicates that dietary Mg intake is significantly and inversely associated with serum CRP levels. The potential beneficial effect of Mg intake on chronic diseases may be, at least in part, explained by inhibiting inflammation.