[Effect of ascorbic acid on the renal transport of endogenous nitrates and nitrites in humans].

Effect of ascorbic acid on the renal excretion of endogenous nitrates and nitrites under aqueous-salt load was studied in practically healthy females. The administration of ascorbic acid in a dose of 10 mg/kg body weight under these conditions favored a decrease in the renal excretion of endogenous nitrates due to modulation of their renal clearance mechanism.

[Reconstructive vascular surgery in stenosis and kinking of the internal carotid artery]. / Vosstanovitel'nye sosudistye operatsii pri kombinatsii stenoza i kinkinga vnutrennei sonnoi arterii.

Combination of stenosis and kinking of the internal carotid artery was revealed in 7.9% of 126 patients who underwent operation for stenosis of the bifurcation of the carotid artery. Among 9 patients with kinking of the internal carotid artery (ICA) 5 had a C-shaped kink, 2 - an S-shaped kink, and 2 patients looping of the artery. The combination led to a great measure to diminished volumetric cerebral blood flow (30-35 ml/min/g). The operations were performed under conduction anesthesia. Average time of ICA compression - 13 min. 26 sec. Retrograde pressure ranged from 42 to 88 mm Hg. In 2 cases the ICA was implanted into a new opening in the common carotid artery after eversion endarterectomy. The defect in the bifurcation was sutured. In 5 cases (4 with a C-shaped kink and 1 with an S-shaped kink) the artery was replanted into the former opening after eversion endarterectomy and resection of the kinked segment of the ICA. In 2 patients with looping of the artery the loop was resected with end to end anastomosis into the ICA and typical endarterectomy from the bifurcation of the carotid artery. There were no fatal outcomes. The results of operative treatment were good.

[Surgical treatment of pathologic twisting of the internal carotid arteries]. / Khirurgicheskoe lechenie patologicheskoi izvitosti vnutrennikh sonnykh arterii.

A total of 5182 carotid angiograms were reviewed. Abnormal bending of the internal carotid artery was detected in 310 (16.4%) cases. Forty-seven such cases were analysed. Twenty-five operations were performed, including the resection with end-to-end anastomosis (8), the resection with redressing and implantation into the former opening on the common carotid artery for loop formation (6) or S-bending (7). In one case of C-bending in the internal and external carotid arteries, the kinking was eliminated by means of a resection of a part of the common carotid artery. Indications for surgery are specified with reference to the kinking variant. Optimum types of reconstructions are proposed. There were no fatal outcomes. Seventeen patients were followed up for up to 5 years. The results of surgical treatment were fairly good.