RESUMO
The administration of thyroxin (10 microg/100 g body weight, 7 days) in rats leads to an increase in the renal excretion of proteins and nitrates. Under the conditions of hypo- and normosodium diet, thyroxin decreased the rate of glomerular filtration. Hypersodium diet and captopril increased the rate of glomerular filtration in rats with experimental hyperthyreosis. The maximum level of renal excretion in hyperthyreoidal rats was observed on the background of sodium-rich diet.
Assuntos
Anti-Hipertensivos/farmacologia , Captopril/farmacologia , Hipertireoidismo/fisiopatologia , Rim/efeitos dos fármacos , Sódio/farmacologia , Animais , Anti-Hipertensivos/administração & dosagem , Captopril/administração & dosagem , Dieta Hipossódica , Taxa de Filtração Glomerular/efeitos dos fármacos , Hipertireoidismo/induzido quimicamente , Hipertireoidismo/metabolismo , Rim/fisiopatologia , Masculino , Ratos , Ratos Endogâmicos , Sódio/administração & dosagem , Sódio/metabolismo , Tiroxina/toxicidade , Equilíbrio Hidroeletrolítico/efeitos dos fármacosRESUMO
A 50 mcg/100 g b.w. single dose of thyroxine was injected to non-inbred white rat males with body mass 140-180 g in conditions of 5% water and osmotic (3% solution of sodium chloride) load, then renal function was studied. This injection reduced creatinine clearance and phosphate excretion, raised nitrate and protein excretion. The kidney of the hyperthyroid animals retains ability to increase creatinine clearance in response to osmotic load. Thus, the above model demonstrates that in the absence of thyroxine renal toxicity it changes homeostatic renal functions both at the vascular-glomerular and tubular levels.
Assuntos
Hipertireoidismo/fisiopatologia , Rim/fisiopatologia , Tiroxina/toxicidade , Animais , Modelos Animais de Doenças , Diurese/efeitos dos fármacos , Diurese/fisiologia , Hipertireoidismo/induzido quimicamente , Rim/efeitos dos fármacos , Testes de Função Renal , Masculino , Concentração Osmolar , Ratos , Cloreto de Sódio/farmacologia , Tiroxina/sangue , UrináliseAssuntos
Carcinógenos/farmacocinética , Rim/metabolismo , Nitratos/farmacocinética , Administração Oral , Animais , Carcinógenos/administração & dosagem , Carcinógenos/toxicidade , Diurese/efeitos dos fármacos , Diurese/fisiologia , Relação Dose-Resposta a Droga , Taxa de Filtração Glomerular/efeitos dos fármacos , Rim/efeitos dos fármacos , Masculino , Taxa de Depuração Metabólica/efeitos dos fármacos , Taxa de Depuração Metabólica/fisiologia , Nitratos/administração & dosagem , Nitratos/toxicidade , RatosRESUMO
Mechanisms of the renal function were studied in white mice subjected to water and hyperosmotic tests. Excretion of excess osmotically active substances appeared to be affected by as modulation of the tubular transport, so intensification of the glomerular filtration through activation of the functional kidney reserve and involvement of renal nitrogen oxide.
Assuntos
Homeostase/fisiologia , Rim/efeitos dos fármacos , Rim/fisiologia , Sais/farmacologia , Animais , Masculino , Camundongos , Concentração Osmolar , Sais/administração & dosagemRESUMO
A method for evaluating the renal clearance of antipyrine is proposed. The analyses were performed for a group of healthy females of reproductive age. The renal clearance of nontransformed antipyrine is found to be significant and the basic indices of renal activity (diuresis, creatinine excretion) are correlated with the drug concentration in saliva. A single administration of antipyrine in a dose of 10 mg/kg does not influence the renal function of healthy volunteers. The proposed photometric method of antipyrine determination in urine (under the conditions of loading with 0.5% NaCl solution at an amount of 0.5% of body weight) is sufficiently sensitive and provides information about the renal clearance of antipyrine, offering an important supplement to the data obtained by conventional methods.