Effect of Electrolyte Concentration and Pore Size on Ion Current Rectification Inversion.

A thorough understanding of nanoscale transport properties is vital for the development and optimization of nanopore sensors. The thickness of the electrical double layers (EDLs) at the internal walls of a nanopore, as well as the dimensions of the nanopore itself, plays a crucial role in determining transport properties. Herein, we demonstrate the effect of the electrolyte concentration, which is inversely proportional to the EDL thickness, and the effect of pore size, which controls the extent of the electrical double layer overlap, on the ion current rectification phenomenon observed for conical nanopores. Experimental and numerical results showed that as the electrolyte concentration is decreased, the rectification ratio reaches a maximum, then decreases, and eventually inverts below unity. We also show that as the pore size is decreased, the rectification maximum and the inversion take place at higher electrolyte concentrations. Numerical investigations revealed that both phenomena occur due to the shifting of ion enrichment distributions within the nanopore as the electrolyte concentration or the pore size is varied.

Application of the Multi-Process Action Control Model to Predict Physical Activity During Late Adolescence.

The aim of this study was to apply the Multi-Process Action Control model to examine how the additions of regulatory and reflexive processes predict physical activity (PA) behaviors among adolescents. Our sample included 1,176 Grade 11 students (Mage = 15.85 ± 0.38) recruited from a large school board in Southern Ontario. Participants completed a questionnaire including measures of self-reported PA and PA cognitions derived from the Multi-Process Action Control model. Results found the reflective process explaining 16.5% of the variance in PA, with the additions of regulatory and reflexive processes significantly improving the explained variance by 5.1% and 8.2%, respectively. Final models revealed coping planning (estimate = 45.10, p = .047), identity (estimate = 55.82, p < .001), and habit (estimate = 64.07, p < .001) as significant predictors of PA. Findings reinforce the need for integrative models to better understand PA, with coping planning, habit formation, and development of an active identity to be salient targets for intervention during adolescence.

Prevalence and Risk Factors of Breathlessness Across Canada: A National Retrospective Cohort Study in Home Care and Nursing Home Populations.

CONTEXT: Breathlessness is a symptom associated with poor clinical outcomes and prognosis. Little is known about its long-term trends and associations with social factors including decline in social activities and caregiver distress. OBJECTIVES: To describe factors associated with the prevalence of clinician-reported breathlessness across Canada among cohorts receiving home care or nursing home care. METHODS: A retrospective observational cohort study of cross-sectional intake assessment data from Canadian interRAI Home Care and Nursing Home data sets. In each data set, we examined covariates associated with the presence of clinician-reported breathlessness using multivariate regression. RESULTS: Between 2007 and 2018, we identified 1,317,117 and 469,709 individuals from the home care and nursing home data sets, respectively. Over two-thirds were aged >75 and over 60% were women. Breathlessness was present at intake in 26.0% of the home care and 8.2% of the nursing home cohorts. Between 2007 and 2018, prevalence of breathlessness increased by 10% for the home care cohort, while remaining relatively constant in nursing homes. Covariates associated with increased odds of having clinician-reported breathlessness at intake in both cohorts were moderate-severe impairment with activities of daily living, being male, older age, high pain scores, signs of depression, and decline in social activities. In the home care cohort, the presence of breathlessness was associated with a greater odds of caregiver distress (odds ratio = 1.19, 95% CI: 1.18-1.20). CONCLUSION: The prevalence of clinician-reported breathlessness is higher in home care than in nursing home populations, the former having risen by 10% over the decade. Prevalence of breathlessness is associated with decline in social activities and caregiver distress. Enhanced supports may be required to meet increasing patient need in the community.

Acute Effects of an Afterschool Running and Reading Program on Executive Functioning in Children: An Exploratory Study.

Objective: Emerging research within school settings suggests acute forms of physical activity and exercise lead to improvements in executive functioning among children. However, research pertaining to these effects within the afterschool setting remains limited. The primary purpose of this study was to investigate the acute effects of a community-based afterschool running and reading program on executive functioning in 8 to 12-year-old children. Method: Fifty participants were initially recruited to participate in this study. However, due to the COVID-19 pandemic, data collection was terminated prematurely which resulted in a sample size of 15 participants. Participants (N = 10) from School 1 completed two batteries of executive function assessments (i.e., inhibition, switching, and updating) separated by 15-min of running or 15-min of sedentary reading. Whereas, only 5 participants from School 2 completed assessments of executive functioning prior to and following the running portion of the program (due to the early termination of data collection). Results: Overall, executive function scores improved across each assessment following the running condition when compared to the reading condition (School 1). Inhibition scores significantly improved, and these effects were very large (School 1). Across both schools, improvements in executive functioning following the running portion of the program ranged from small-large in effect size. Conclusion: Findings from the present study provide initial evidence for the acute effects of a community-based afterschool running and reading program on executive functioning in children. Future research with larger samples in afterschool settings is recommended to replicate this preliminary work.

External validation demonstrated the Ottawa SAH prediction models can identify pSAH using health administrative data.

OBJECTIVES: The objective of the study is to externally validate three primary subarachnoid hemorrhage (pSAH) identification models. STUDY DESIGN AND SETTING: We evaluated three models that identify pSAH using recursive partitioning (A), logistic regression (B), and a prevalence-adjusted logistic regression(C), respectively. Blinded chart review and/or linkage to existing registries determined pSAH status. We included all patients aged ≥18 in four participating center registries or whose discharge abstracts contained ≥1 administrative codes of interest between January 1, 2012 and December 31, 2013. RESULTS: A total of 3,262 of 193,190 admissions underwent chart review (n = 2,493) or registry linkage (n = 769). A total of 657 had pSAH confirmed (20·1% sample, 0·34% admissions). The sensitivity, specificity, and positive predictive value (PPV) were as follows: i) model A: 98·3% (97·0-99·2), 53·5% (51·5-55·4), and 34·8% (32·6-37·0); ii) model B (score ≥6): 98·0% (96·6-98·9), 47·4% (45·5-49·4), and 32·0% (30·0-34·1); and iii) model C (score ≥2): 95·7% (93·9-97·2), 85·5% (84·0-86·8), and 62·3 (59·3-65·3), respectively. Model C scores of 0, 1, 2, 3, or 4 had probabilities of 0·5% (0·2-1·5), 1·5% (1·0-2·2), 24·8% (21·0-29·0), 90·0% (86·8-92·0), and 97·8% (88·7-99·6), without significant difference between centers (P = 0·86). The PPV of the International Classification of Diseases code (I60) was 63·0% (95% confidence interval: 60·0-66·0). CONCLUSIONS: All three models were highly sensitive for pSAH. Model C could be used to adjust for misclassification bias.

Methods and design for the ADAPT study: Application of integrateD Approaches to understanding Physical activity during the Transition to emerging adulthood.

BACKGROUND: The overarching objective of the study is to obtain a comprehensive understanding of the salient factors predicting changes in physical activity (PA) during adolescents' transition into emerging adulthood. Using the Multi-Process Action Control model as our guiding framework, we will examine how implicit and explicit psychological processes along with regulatory practices impact PA change during this major life transition. Additionally, we will use a real-time data capture method called Ecological Momentary Assessment to further investigate how environmental and contextual factors, and momentary psychosocial influences effect PA patterns across this dynamic life stage. METHODS: The ADAPT study is a 4-year project comprised of two interrelated studies. Study I is a large prospective cohort study that will invite all grade 11 students across one large school board (a total of seven secondary schools) to participate by completing an online questionnaire. Using a cluster randomization approach, a subset of students from each school will be invited to participate in Study II, whereby participants will wear an accelerometer and complete Ecological Momentary Assessments 5 times a day over a 7-day study period. For both studies, following baseline assessments, there will be three annual follow-up assessments approximately 12 months apart. DISCUSSION: The current study represents one of the largest longitudinal cohort studies examining PA and its determinants and associated consequences among adolescents transitioning out of high school into emerging adulthood. Findings from this study will provide a much more in-depth understanding of how and why changes in PA behaviour occur across this first major life transition.