RESUMO
The treatment of Graves' disease is based on three therapies: medical treatment with synthetic antithyroid agents, surgery and radioactive-iodine therapy. The purpose of our study was to study the role and effectiveness of radioactive-iodine therapy for the treatment of Graves' disease. We conducted a retrospective, descriptive study of the epidemiological, clinical, paralclinical and therapeutic features of 54 patients with Graves' disease managed and treated with iodine-131 as well as of their short- and medium-term remission rate. The sex ratio was 0.45. The average age of patients was 38,33 ± 12.7 years. The most common functional signs were weight loss, tremors and palpitations. Mean FT4 was 54,51 ± 19,56 ng/dl (ranging from 8,90 and 100). Mean TSHus was 0,074 ± 0,29 µIU/ml. Synthetic antithyroid drugs were used in 49 patients; 83,67% of cases had persistent hyperthyroidism. Radioactive-iodine therapy was used as first-line therapy in 9,3% of cases and as second-line therapy in 90,7% of cases. Mean activity was 13,29 mCi ± 1,46 ranging from 10 to 15 mCi. The first assessment of hormonal status was performed after an average post-treatment period of 1,91 months; 29 patients (53,7%) achieved remission (eu- or hypo-thyroidism). After a 12 month-follow-up, patients' course was marked by remission in 88,88% of cases (euthyroidism in 14,8% and hypothyroidism in 74% of cases). Radioactive-iodine therapy is an effective treatment for Graves' disease. High radioactive iodine dose provides high remission rate.
Assuntos
Doença de Graves/radioterapia , Radioisótopos do Iodo/uso terapêutico , Adulto , Idoso , Antitireóideos/uso terapêutico , Estudos Transversais , Feminino , Doença de Graves/sangue , Doença de Graves/epidemiologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Testes de Função Tireóidea , Hormônios Tireóideos/sangue , Resultado do Tratamento , Adulto JovemRESUMO
A 65-year-old woman presented with a neuroendocrine pancreatic head tumor and known liver and bone metastasis. We performed Tc-99m-tektrotyd scintigraphy on this patient, which showed more developed diffuse bone metastases, in addition to the known lesions.
RESUMO
False positive radioiodine uptake following thyroidectomy for differentiated thyroid cancer has been reported in some cases. A 57-year-old female patient was referred for ablative radioiodine treatment four weeks after undergoing total thyroidectomy for papillary thyroid carcinoma. Posttherapeutic I-131 scintigraphy showed uptake in the neck and large focus in the lower abdomen and pelvis. Pathology revealed a mucinous adenocarcinoma of the right ovary.
Assuntos
Adenocarcinoma Mucinoso/diagnóstico , Neoplasias Ovarianas/diagnóstico , Imagem Corporal Total , Adenocarcinoma Mucinoso/patologia , Reações Falso-Positivas , Feminino , Humanos , Radioisótopos do Iodo , Pessoa de Meia-Idade , Neoplasias Ovarianas/patologia , Câncer Papilífero da Tireoide/cirurgia , Neoplasias da Glândula Tireoide/cirurgia , TireoidectomiaRESUMO
Usually differentiated thyroid cancer is a slow growing tumor with low metastatic potential. We present the case of female patient of 26-years-old who underwent thyroidectomy, followed by 3.7 GBq of 131 I. The post-therapeutic whole-body scan showed intense uptake in the left part of posterior thorax and a faint radioactivity in the upper right tibia. A Chest CT-scan and a localized knee MRI confirm that they are bone metastasis in the middle portion of the 8th right rib and in the upper tibial metaphysic.