Parental loneliness, perceptions of parenting, and psychosocial factors among parents having new children during the COVID-19 pandemic.

Individuals who had new children during the coronavirus disease 2019 (COVID-19) pandemic became parents in challenging situations, starting from pregnancy and continuing to after birth. This study aimed to clarify the characteristics of parental loneliness, perceptions of parenting, and psychosocial factors among parents having new children during the COVID-19 pandemic. The participants comprised a first-child group (523 parents; those who had their first child) and a second-child group (621 parents; those who had their second or subsequent child). We used web-based questionnaires to explore parental loneliness, perceptions of parenting, and psychosocial factors (distress, parental burnout, well-being, marital satisfaction, and social isolation). Participants answered the questionnaires in November 2022, during the eighth COVID-19 wave in Japan. We compared the groups and subgroups according to parental sex and determined the relationship between variables. The parents in the first-child group felt lonelier than the parents in the second-child group (p < 0.05), and their loneliness was correlated with psychosocial factors. Significantly, more mothers in the second-child group answered "agree" to negative perceptions of parenting than mothers in the first-child group. Additionally, parenting difficulties were correlated with a negative perception of parenting and parental burnout in both groups. Furthermore, providing parental support may improve parenting and promote parents' health.

Changes in parental involvement and perceptions in parents of young children during the COVID-19 pandemic: A cross-sectional observational study in Japan.

This study aimed to clarify changes in parental involvement with their children and parental perceptions related to parenting in both fathers and mothers of young children during the coronavirus disease 2019 (COVID-19) pandemic. A cross-sectional observational design was used. Data were collected using a web-based questionnaire from 28 fathers and 115 mothers between October 1 and November 30, 2020. Parents answered questions regarding themselves, basic sociodemographic variables, perceived changes in involvement with their children, the presence or absence of abusive behavior (e.g., violence toward children), and parental perceptions related to parenting. Many parents indicated that they did not experience major changes in their involvement or perceptions compared to before the COVID-19 pandemic. Half of the fathers considered themselves to be in more physical contact or communication with their children; there was a significant difference between fathers and mothers regarding eating meals with their children (p = 0.00). Fathers felt tired due to parenting (35.7%) or a lack of free time (42.9%) during the COVID-19 pandemic. While significantly more mothers than fathers responded that their partners took care of their children (p = 0.03), significantly greater number of mothers than fathers also reported feeling overburdened (p = 0.00). Family support workers should help fathers maintain involvement with their young children without high stress levels and support mothers to reduce their heavy burden of parenting continuously. This would contribute to young childrens growth and development despite a public health crisis.

Associations between serum high-density lipoprotein cholesterol or apolipoprotein AI levels and common genetic variants of the ABCA1 gene in Japanese school-aged children.

ATP-binding cassette transporter A1 (ABCA1) plays an important role in apolipoprotein AI (apoAI)-mediated cholesterol efflux from peripheral cells. The mild changes in ABCA1 activity due to genomic variation might be associated with interindividual variations in serum high-density lipoprotein cholesterol (HDL-C) and apoAI levels, or primary hypoalphalipoproteinemia in the general population. In the present study, we analyzed the relationships between 5 single nucleotide polymorphisms (SNPs) and 2 insertion/deletion polymorphisms in the 5' flanking region and 5 missense polymorphisms of the ABCA1 gene and serum lipid levels in healthy school-aged children. We detected significant associations between the K219R and V771M polymorphisms, and HDL-C or apoAI levels. The present data support the proposition that the K219 allele is an anti-atherogenic allele with increased cholesterol efflux activity. Similarly, the M771 allele appears to be anti-atherogenic, although the frequency of the M771 allele is low.

Relationship between serum HDL-C levels and common genetic variants of the endothelial lipase gene in Japanese school-aged children.

Endothelial lipase (EL) is a new member of the triglyceride lipase family, the genes of which play a central role in dietary fat absorption, energy homeostasis, and plasma lipoprotein metabolism. One physiologic role of EL is thought to be hydrolysis of high-density lipoprotein (HDL) phospholipid, although the precise function of endothelial lipase has yet to be fully clarified. Furthermore, genetic variation in EL has been suggested to influence serum HDL-C levels. In the present study, we detected two common single nucleotide polymorphisms in the EL gene associated with serum HDL cholesterol levels in healthy school-aged children. Our data support the hypothesis that variations in the EL gene are one of the genetic determinants of serum HDL-C levels.

Association found between the promoter region polymorphism in the apolipoprotein A-V gene and the serum triglyceride level in Japanese schoolchildren.

The purpose of this study was to assess the influence of single nucleotide polymorphism 3 (SNP3) of the apolipoprotein A-V ( APOA5) gene on the serum triglyceride (TG) level in Japanese schoolchildren. To determine the frequency of the genotype, we analyzed 552 schoolchildren. The frequencies of the T/T, T/C and C/C genotypes of the APOA5 gene were 225 (40.8%), 263 (47.6%) and 64 (11.6%), respectively. The serum TG level was significantly different among the genotypic groups after adjustments for age, gender and obesity index (T/T 71.6+/-34.8 mg/dl, T/C 80.7+/-36.1 mg/dl, C/C 94.4+/-69.4 mg/dl, P<0.0001). The odds ratio (95% confidence interval) for hypertriglyceridemia of the C allele was 2.4 (1.0-6.2). Our data suggested that the T/C promoter region polymorphism of the APOA5 gene appears to be a genetic risk factor for hypertriglyceridemia in Japanese children.