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1.
Transplant Proc ; 50(10): 3559-3561, 2018 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-30577237

RESUMO

BACKROUND: Hepatic artery (HA) anastomosis is still a challenge in living donor liver transplantation due to the short- and small-caliber graft artery. PATIENTS AND METHODS: If the recipient HA is damaged, reconstruction of HA is a significant problem. This paper reports on the results of using our alternative artery source in patients who had HA depredation for a variety of reasons, including transarterial chemoembolization. We used the right gastroepiploic hepatic artery for HA reconstruction in 5 patients. RESULTS: None of the patients experienced HA thrombosis. Only one patient who underwent retransplantation due to chronic rejection had biliary leakage. The mean follow-up time was 7.4 months; no graft loss or patient mortality was observed. The right gastroepiploic hepatic artery can be used securely for HA reconstruction in patients with a damaged HA.


Assuntos
Artéria Gastroepiploica/cirurgia , Artéria Hepática/cirurgia , Transplante de Fígado/métodos , Procedimentos de Cirurgia Plástica/métodos , Procedimentos Cirúrgicos Vasculares/métodos , Adulto , Anastomose Cirúrgica/métodos , Feminino , Humanos , Doadores Vivos , Masculino , Pessoa de Meia-Idade
2.
Hippokratia ; 22(1): 43-48, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-31213757

RESUMO

BACKGROUND: Ghrelin is a physiologic regulatory hormone of appetite and body weight, and its concentrations increase in chronic kidney disease. This study aimed to analyze the effects of malnutrition and depression on the plasma ghrelin levels in peritoneal dialysis (PD) patients. METHODS/PATIENTS: The relationship between fasting serum ghrelin concentration, type of dialysate solution, malnutrition-inflammation score (MIS), and depressive symptoms of 87 PD patients were analyzed. Depressive symptoms were evaluated using the Beck Depression Inventory. RESULTS: No significant relationship between ghrelin concentration and body mass index (BMI), MIS or depression scores was detected. The mean serum ghrelin concentration in patients using amino acid-based solutions was higher than in non-users (p <0.001). The mean serum ghrelin concentration of the patients using icodextrin-based solutions was found to be significantly higher than non-users (8.69 ± 5.04 vs 6.61 ± 2.8 ng/ml respectively, p =0.02). There was no significant difference in MIS between the patients in terms of amino-acid and/or icodextrin usage. CONCLUSIONS: There is no association between BMI, MIS, and depression with ghrelin concentrations in PD patients. Icodextrin and/or amino acid-based solutions usage may increase the serum ghrelin concentration without a significant effect on BMI and measures of malnutrition. HIPPOKRATIA 2018, 22(1): 43-48.

3.
J Psychiatr Ment Health Nurs ; 23(1): 22-36, 2016 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-26272790

RESUMO

INTRODUCTION: Working with people with a personality disorder (PD) can arouse strong feelings, and cause difficulties as well as different attitudes among mental health workers (MHWs). While attitudes towards people with PD and the difficulties experienced by MHWs have been previously investigated, the reciprocal relationship between the two has not been thoroughly investigated. AIM/QUESTION: This study aims to investigate (1) affective reactions of MHWs to people with personality disorders, (2) the difficulties that MHWs experience while working with these patients, (3) their attitudes towards these patients, and (4) the interaction between these variables. METHOD: The data for this study were collected through a Personal Information Questionnaire, the Difficulty of Working with Personality Disorders Scale and the Attitudes towards Patients with Personality Disorders Scale from 332 MHWs from several mental health clinics in Turkey, all of whom were experienced in working with people with PD. RESULTS: The results indicate that the participants described 'difficulty in forming a relationship, understanding the client, and establishing cooperation' among the primary reasons of difficulties. This study also shows that there is a strong relationship between MHWs' feelings of boredom/discontent, guilt/pity and a tendency to display positive behaviours/an inability of establishing borders against people with PD. DISCUSSION: The findings of this study imply that the level of education, expertise, psychotherapy treatment and clinical supervision of MHWs all affect perceived difficulties and attitudes towards people with PD. It is also noted that among nurses, a higher level of education results in reduced experience of difficulties while working with patients with PD. IMPLICATION FOR PRACTICE: The results foreground the need for specific skills to be developed in MHWs through theoretical training, case-focused supervision and receiving personal psychotherapy for MHWs.


Assuntos
Atitude do Pessoal de Saúde , Transtornos da Personalidade/terapia , Relações Profissional-Paciente , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
4.
Minerva Cardioangiol ; 62(3): 287-95, 2014 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-24831765

RESUMO

AIM: Lipid-lowering therapy (LLT) is a key factor in the prevention of cardiovascular mortality and morbidity in diabetic patients. Current guidelines have expanded the population of patients with diabetes for whom aggressive low-density lipoprotein cholesterol (LDL-C) lowering therapy should be considered. This study evaluated the management of dyslipidemia in patients with type 2 diabetes in real life. METHODS: Secondary care physicians in a tertiary center recruited 707 patients. The prevalence of statin use along with the achievement of cholesterol targets, predictors for receiving statin, and possible reasons for lack of therapy were investigated. RESULTS: Only 33% of the patients had received statin therapy, and this was significantly higher in those with cardiovascular disease (47% versus 27%; P<0.001). Most of the patients had LDL-C levels of >100 mg/dL (77%), with only 5% having LDL-C levels of <70 mg/dL. Forty-one percent of the patients had never been prescribed LLT previously while 26% had been prescribed this type of therapy in the past but had stopped using it. The most frequent reason for discontinuation of the statin therapy was a physician's advice to stop the medication. The patients taking statins had similar LDL-C levels as those who had never been prescribed statins and those who had discontinued their use of statins on the advice of a physician. CONCLUSION: The majority of diabetic patients are undertreated with statins and minority of them achieve LDL-C target levels. Our findings suggest that there is a large discrepency between evidence-based recommendations and physicians' treatment attitudes.


Assuntos
Diabetes Mellitus Tipo 2/tratamento farmacológico , Dislipidemias/tratamento farmacológico , Inibidores de Hidroximetilglutaril-CoA Redutases/uso terapêutico , Guias de Prática Clínica como Assunto , Idoso , Doenças Cardiovasculares/etiologia , Doenças Cardiovasculares/prevenção & controle , LDL-Colesterol/sangue , Estudos Transversais , Diabetes Mellitus Tipo 2/complicações , Dislipidemias/complicações , Medicina Baseada em Evidências , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Padrões de Prática Médica , Estudos Prospectivos , Turquia
5.
Radiat Prot Dosimetry ; 156(4): 489-94, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23595410

RESUMO

Radon ((222)Rn) measurements were undertaken in 16 samples of well water representing different depths and different types of aquifers found at the city centre of Konya, Central Turkey. The radon activity concentrations of the well water samples collected in the spring and summer seasons of 2012 were measured by using the radon gas analyser (AlphaGUARD PQ 2000PRO). The radon concentrations for spring and summer seasons are 2.29 ± 0.17 to 27.25 ± 1.07 and 1.44 ± 0.18 to 27.45 ± 1.25 Bq l(-1), respectively. The results at hand revealed that the radon concentration levels of the waters strictly depend on the seasons and are slightly variable with depth. Eleven of the 16 well water samples had radon concentration levels below the safe limit of 11.11 Bq l(-1) recommended by the United States Environmental Protection Agency. However, all measured radon concentration levels are well below the 100 Bq l(-1) safe limit declared by the World Health Organisation. The doses resulting from the consumption of these waters were calculated. The calculated minimum and maximum effective doses are 0.29 and 5.49 µSv a(-1), respectively.


Assuntos
Água Potável/análise , Monitoramento de Radiação/instrumentação , Radônio/análise , Poluentes Radioativos da Água/análise , Abastecimento de Água/análise , Água Subterrânea , Monitoramento de Radiação/métodos , Estações do Ano , Temperatura , Turquia
6.
Eur Rev Med Pharmacol Sci ; 17(24): 3309-17, 2013 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-24379061

RESUMO

AIM: The aim of the present study was to analyze the relationship between epicardial adipose tissue thickness (EATT) and echocardiographic parameters, such as carotid intima-media thickness (cIMT), myocardial performance index (MPI), left ventricular (LV) systolic and diastolic function, and LV mass index in adolescents with obesity. PATIENTS AND METHODS: One hundred and thirty eight obese adolescents and 63 lean subjects were enrolled in the study. The body mass index standard deviation scores (BMI-SDS) between 1.65-2.49 and 2.50-2.99 were considered as mild-moderate and severe obesity, respectively. All of the subjects underwent transthoracic echocardiographic examination for determination of LV function, LV structure, LV mass index, and MPI. Epicardial adipose tissue thickness and cIMT were also measured during echocardiography. RESULTS: The EATT measurements were increased significantly in patients with severe obesity compared to lean subjects (7.38±1.76 vs 4.28±0.79 mm, respectively; p = 0.001), but there was no significant difference between the obesity groups. The average LV mass index measurements were higher in both mild-moderately and severely obese patients in comparison with the lean children (87.5±34.8, 88.5±23.0, and 62.4±18.2 g/m2, respectively; p < 0.01), but there was no significant difference between the obesity groups. EATT was positively correlated with BMI-SDS, waist and hip circumference, blood pressure, fasting glucose, insulin, HOMA-IR, hs-CRP (high-sensitivity C-reactive protein), triglyceride levels, cIMT, LV mass index, and MPI in the severe obesity group. EATT was the only independent predictor of cIMT in the multivariate analysis (standardized ß coefficient = 0.70, p < 0.001). CONCLUSIONS: The present study demonstrates a close relationship between EATT and cIMT, and LV functions and LV mass index in obese adolescents. Assessments of EATT and cIMT in particular during routine echocardiographic examinations might be used as a feasible and reliable method for the evaluation of obesity and its related cardiovascular risks during childhood.


Assuntos
Tecido Adiposo/diagnóstico por imagem , Adiposidade , Doenças das Artérias Carótidas/etiologia , Artéria Carótida Primitiva/diagnóstico por imagem , Espessura Intima-Media Carotídea , Ecocardiografia Doppler , Cardiopatias/etiologia , Obesidade Infantil/complicações , Pericárdio/diagnóstico por imagem , Tecido Adiposo/fisiopatologia , Adolescente , Índice de Massa Corporal , Doenças das Artérias Carótidas/diagnóstico por imagem , Doenças das Artérias Carótidas/fisiopatologia , Estudos de Casos e Controles , Criança , Diástole , Feminino , Cardiopatias/diagnóstico por imagem , Cardiopatias/fisiopatologia , Humanos , Masculino , Análise Multivariada , Obesidade Infantil/diagnóstico por imagem , Obesidade Infantil/fisiopatologia , Pericárdio/fisiopatologia , Valor Preditivo dos Testes , Fatores de Risco , Índice de Gravidade de Doença , Sístole , Função Ventricular Esquerda
7.
Braz. j. med. biol. res ; 40(12): 1647-1652, Dec. 2007. graf, tab
Artigo em Inglês | LILACS | ID: lil-466742

RESUMO

Upper gastrointestinal endoscopy is often accompanied by tachycardia which is known to be an important pathogenic factor in the development of myocardial ischemia. The pathogenesis of tachycardia is unknown but the condition is thought to be due to the endocrine response to endoscopy. The purpose of the present study was to investigate the effects of sedation on the endocrine response and cardiorespiratory function. Forty patients scheduled for diagnostic upper gastrointestinal endoscopy were randomized into 2 groups. While the patients in the first group did not receive sedation during upper gastrointestinal endoscopy, the patients in the second group were sedated with intravenous midazolam at the dose of 5 mg for those under 65 years or 2.5 mg for those aged 65 years or more. Midazolam was administered by slow infusion. In both groups, blood pressure, ECG tracing, heart rate, and peripheral oxygen saturation (SpO2) were monitored during endoscopy. In addition, blood samples for the determination of cortisol, glucose and C-reactive protein levels were obtained from patients in both groups prior to and following endoscopy. Heart rate and systolic arterial pressure changes were within normal limits in both groups. Comparison of the two groups regarding the values of these two parameters did not reveal a significant difference, while a statistically significant reduction in SpO2 was found in the sedation group. No significant differences in serum cortisol, glucose or C-reactive protein levels were observed between the sedated and non-sedated group. Sedation with midazolam did not reduce the endocrine response and the tachycardia developing during upper gastrointestinal endoscopy, but increased the reduction in SpO2.


Assuntos
Adulto , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Anestésicos Intravenosos/uso terapêutico , Pressão Sanguínea/efeitos dos fármacos , Gastroscopia/efeitos adversos , Frequência Cardíaca/efeitos dos fármacos , Midazolam/uso terapêutico , Taquicardia/etiologia , Proteína C-Reativa/análise , Eletrocardiografia , Glucose/análise , Hidrocortisona/sangue , Oxigênio/sangue , Taquicardia/prevenção & controle
8.
Braz J Med Biol Res ; 40(12): 1647-52, 2007 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-17876425

RESUMO

Upper gastrointestinal endoscopy is often accompanied by tachycardia which is known to be an important pathogenic factor in the development of myocardial ischemia. The pathogenesis of tachycardia is unknown but the condition is thought to be due to the endocrine response to endoscopy. The purpose of the present study was to investigate the effects of sedation on the endocrine response and cardiorespiratory function. Forty patients scheduled for diagnostic upper gastrointestinal endoscopy were randomized into 2 groups. While the patients in the first group did not receive sedation during upper gastrointestinal endoscopy, the patients in the second group were sedated with intravenous midazolam at the dose of 5 mg for those under 65 years or 2.5 mg for those aged 65 years or more. Midazolam was administered by slow infusion. In both groups, blood pressure, ECG tracing, heart rate, and peripheral oxygen saturation (SpO2) were monitored during endoscopy. In addition, blood samples for the determination of cortisol, glucose and C-reactive protein levels were obtained from patients in both groups prior to and following endoscopy. Heart rate and systolic arterial pressure changes were within normal limits in both groups. Comparison of the two groups regarding the values of these two parameters did not reveal a significant difference, while a statistically significant reduction in SpO2 was found in the sedation group. No significant differences in serum cortisol, glucose or C-reactive protein levels were observed between the sedated and non-sedated group. Sedation with midazolam did not reduce the endocrine response and the tachycardia developing during upper gastrointestinal endoscopy, but increased the reduction in SpO2.


Assuntos
Anestésicos Intravenosos/uso terapêutico , Pressão Sanguínea/efeitos dos fármacos , Gastroscopia/efeitos adversos , Frequência Cardíaca/efeitos dos fármacos , Midazolam/uso terapêutico , Taquicardia/etiologia , Adulto , Idoso , Proteína C-Reativa/análise , Eletrocardiografia , Feminino , Glucose/análise , Humanos , Hidrocortisona/sangue , Masculino , Pessoa de Meia-Idade , Oxigênio/sangue , Taquicardia/prevenção & controle
9.
Eur J Vasc Endovasc Surg ; 32(6): 690-5, 2006 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-16872850

RESUMO

BACKGROUND: Vascular injuries caused by firearms are rare among children. In this paper we discuss the surgical methods of treating peripheral vascular injuries due to firearms in children. MATERIALS AND METHODS: Forty-four patients with peripheral vascular injuries due to firearms were included in this retrospective study. The patients were under the age of 14 and treated in our clinic between January 1985 and December 2004. RESULTS: Vascular injuries due to firearms in children made up 4.9% of all cases of vascular trauma in our clinic. The male to female ratio was 38:6, and the age range was 3-14. The survival rate was 98% and the rate of limb salvage was 91%. For arterial and venous injuries, a saphenous vein interposition graft and interrupted sutures were often preferred surgically. CONCLUSION: Peripheral vascular injuries due to firearms in children and other accompanying traumas can be easily identified and treated, and have low morbidity and mortality with an acceptable limb salvage rate if a rapid and effective approach is used.


Assuntos
Artérias/lesões , Extremidades/irrigação sanguínea , Armas de Fogo , Procedimentos Cirúrgicos Vasculares , Veias/lesões , Ferimentos por Arma de Fogo/cirurgia , Adolescente , Amputação Cirúrgica , Angiografia , Artérias/diagnóstico por imagem , Artérias/cirurgia , Criança , Pré-Escolar , Feminino , Seguimentos , Oclusão de Enxerto Vascular , Humanos , Salvamento de Membro , Masculino , Estudos Retrospectivos , Veia Safena/transplante , Análise de Sobrevida , Fatores de Tempo , Resultado do Tratamento , Turquia , Ultrassonografia , Grau de Desobstrução Vascular , Procedimentos Cirúrgicos Vasculares/efeitos adversos , Veias/diagnóstico por imagem , Veias/cirurgia , Ferimentos por Arma de Fogo/mortalidade
10.
Ren Fail ; 28(2): 125-8, 2006.
Artigo em Inglês | MEDLINE | ID: mdl-16538969

RESUMO

INTRODUCTION: Tubulointerstitial injury is both a key feature of diabetic nephropathy and an important predictor of renal dysfunction. N-Acetyl B glucosaminidase (NAG) is derived from proximal tubular cells and is widely used to evaluate tubular renal function. OBJECTIVE: The objective of this study is whether NAG can be used as an early marker of diabetic nephropathy by comparing the urinary NAG levels between healthy controls and diabetic patients and determining changes in urinary NAG excretion after treatment with low-dose combination perindopril (2 mg)/ indapamide (0.625 mg)/o.d. MATERIALS AND METHODS: A total of 50 patients (29 female) with type II diabetes mellitus applying to our diabetes outpatient clinics for the first time were included in our study (Group 1). Diabetic patients were classified into three subgroups on the basis of their duration of diabetes: Group 1A (n = 15) < or = 3 years, Group 1B (n = 19) 3 to 5 years, and Group 1c (n = 16) > 5 years. The inclusion criteria were no prior use of antihypertensive agents; blood pressure < 130/85 mmHg; urinary albumin excretion < 30 mg/day; and absence of renal failure, diabetietes, and hypertensive retinopathy. A total of 30 healthy individuals (16 female) (Group 2) were assessed as the control group. Systolic and diastolic blood pressures, HbA1c, body mass index, 24-h microalbuminuria (MAU), and NAG measurements in urine samples were performed by using colorimetric assay method in an analyzer (Roche Cobas Mira). The assay defined as fragmentation of 3-cresolsulfonphthaleinyl-N-acetyl-beta-D-glucosaminide molecule by NAG to 3-cresolsulphonphthalein and N-acetylglucosamine molecules and serum creatinine were measured in all groups. Type II diabetic patients were administered perindopril (2 mg)/indapamide (0.625 mg) combination once daily for 4 months, and urinary NAG levels were measured at the end of treatment. RESULTS: Statistically significant differences were observed between the groups 1 and 2 with respect to the levels of NAG and HbA1c (p < 0.05). In the treatment group, NAG levels decreased significantly (p < 0.05), whereas blood pressure and HbA1c levels did not change significantly (p > 0.05). In diabetic patients, pretreatment NAG were lowest in Group 1A and highest in Group 1c, although the difference between the treatment subgroups was not statistically significant (p > 0.05). CONCLUSION: Urinary NAG excretion is elevated in type II diabetic patients as compared with the healthy individuals. Perindopril/indapamide administration is effective in reducing urinary NAG excretion in these patients, and this effect seems to be independent from blood pressure and glycemia control. Presence of tubular proteinuria may be an early indicator of diabetic renal disease in patients without microalbuminuria. Perindopril (2 mg)/ indapamide (0.625 mg)/o.d. treatment may have beneficial effect on the tubulointerstitial damage in diabetic kidney disease.


Assuntos
Acetilglucosaminidase/urina , Inibidores da Enzima Conversora de Angiotensina/administração & dosagem , Anti-Hipertensivos/administração & dosagem , Nefropatias Diabéticas/tratamento farmacológico , Nefropatias Diabéticas/urina , Indapamida/administração & dosagem , Perindopril/administração & dosagem , Biomarcadores/urina , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
11.
J Cardiovasc Surg (Torino) ; 45(1): 71-5, 2004 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-15041942

RESUMO

AIM: To assess the efficacy of pleural tenting in patients with complicated primary spontaneous pneumothorax (PSP). METHODS: From 1988 through 2001, 43 patients underwent operations. Mean age was 30.4 years; the male/female ratio was 9.7. Twenty-one (48.8%) underwent pleural tenting in addition to bulla excision (experimental group, EG). Twenty-two (51.2%) underwent bulla excision plus pleural abrasion (11 patients), apical partial pleurectomy (9 patients) and complete apical pleurectomy (2 patients) (control group, CG). The most frequent symptom was chest pain (37.2%). Surgical indications were recurrence in 21 (48.8%), prolonged air leak in 12 (27.9%), failure of expansion without air leak in 6 (13.9%), high risk occupancy in 2 (4.6%) and empyema due to air leak in 2 (4.6%). RESULTS: Air leak time was decreased by tenting (1.9 days vs 3.7 days) as well as time of drainage (4.8 vs 6.9) and hospital stay (5.8 vs 7.9). Morbidity was 9.5% in EG and 9.1% in CG. Causes of morbidity were postoperative hematoma, prolonged air leak, expansion failure and blunt posterior sinus one of each. Re-operation needed for postoperative hematoma in CG. Mean follow-up was 5.1 years and 1 (4.5%) recurrence observed in CG. CONCLUSION: Tenting of the dependent lung from the apical pleura after bullectomy via axillary thoracotomy lessens air leak time without recurrence and low morbidity.


Assuntos
Pleura/cirurgia , Pneumonectomia/métodos , Pneumotórax/cirurgia , Retalhos Cirúrgicos , Adolescente , Adulto , Dor no Peito/etiologia , Tubos Torácicos , Drenagem , Dispneia/etiologia , Empiema/etiologia , Feminino , Seguimentos , Hematoma/etiologia , Humanos , Tempo de Internação/estatística & dados numéricos , Masculino , Seleção de Pacientes , Pneumonectomia/efeitos adversos , Pneumotórax/diagnóstico , Pneumotórax/etiologia , Recidiva , Reoperação/estatística & dados numéricos , Fatores de Risco , Taquicardia/etiologia , Fatores de Tempo , Tomografia Computadorizada por Raios X , Resultado do Tratamento
12.
13.
Int Angiol ; 21(4): 384-9, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12518121

RESUMO

BACKGROUND: To evaluate the role of serum lipoprotein-a (Lp-a) levels on the success of thrombolytic therapy (TT) in patients with acute myocardial infarction (MI). PATIENTS: 56 patients randomly allocated into 2 groups (A and B) with an approximately 1 to 2 ratio. Group A consisted of 18 patients who received 1,5 million IU streptokinase. Group B: 38 patients receiving 100 mg t-PA totally and Group C: 22 patients who did not received any TT as controls. All patients had undergone coronary angiography in the first 7 days and the degree of TIMI flow was determined in the infarct related artery with TIMI-0 and I being considered as unsuccessful perfusion, whereas TIMI-II and III as successful. Lp-a level gs;30 mg/dl was considered as high Lp-a level. RESULTS: Patency rates were similar in Group A and B, in cases with high or low Lp-a levels (p>0.05 for both). In Group C patency rate was found significantly higher in patients with high Lp-a level compared to patients with low Lp-a (p<0.01). Lp-a level in Group C was similar with Group A and B (p>0.05). The time interval for coronary angiography was similar in all groups (p>0.05 for all). CONCLUSIONS: Lp-a level does not effect the reperfusion outcome of TT in patients with MI. However in those patients who not received TT, spontaneous reperfusion rate was found significantly higher in patients with low Lp-a level compared to those with high Lp-a level.


Assuntos
Fibrinolíticos/uso terapêutico , Lipoproteína(a)/sangue , Lipoproteína(a)/farmacologia , Infarto do Miocárdio/sangue , Infarto do Miocárdio/tratamento farmacológico , Reperfusão Miocárdica , Avaliação de Resultados em Cuidados de Saúde , Estreptoquinase/uso terapêutico , Terapia Trombolítica , Ativador de Plasminogênio Tecidual/uso terapêutico , Adulto , Idoso , Angiografia Coronária , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Infarto do Miocárdio/diagnóstico por imagem , Grau de Desobstrução Vascular/efeitos dos fármacos
14.
J Thorac Cardiovasc Surg ; 122(4): 741-5, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11581607

RESUMO

OBJECTIVE: Postoperative anemia and multiple blood transfusions are still important problems in cardiac surgery. During the past few years, there have been some reports indicating that multiple recombinant human erythropoietin infusions starting at least 2 weeks before the operation induced erythropoiesis. We aimed to reduce the risk of adverse reactions of high doses of recombinant human erythropoietin and reduce the period of hospitalization by using it only once, 4 days before the operation. METHODS: Twenty-five patients received recombinant human erythropoietin 4 days before the operation, and 28 patients comprised the control group. All the hematologic parameters of the patients are measured on the day of admission, the day before the operation (fourth day), the first day after the operation, and 1 week later. RESULTS: In the recombinant human erythropoietin group the mean hemoglobin concentration increased on the morning of the operation (14.5 +/- 0.52 g/dL in the recombinant human erythropoietin group and 12.4 +/- 0.65 in the control group, P <.05). To maintain hemoglobin levels at greater than 8.5 g/dL, 330 +/- 33 mL of homologous transfusion was required in the recombinant human erythropoietin group, whereas 680 +/- 75 mL was required in the control group (P <.01). CONCLUSION: Recombinant human erythropoietin induces erythropoiesis rapidly, even when it is used with a low single dose just 4 days before the operation. No adverse reactions were seen with this kind of recombinant human erythropoietin treatment.


Assuntos
Ponte de Artéria Coronária , Eritropoese/efeitos dos fármacos , Eritropoetina/administração & dosagem , Cuidados Pré-Operatórios , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Proteínas Recombinantes , Método Simples-Cego , Fatores de Tempo
15.
J Am Soc Echocardiogr ; 14(10): 951-8, 2001 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-11593199

RESUMO

OBJECTIVES: The aim of this study was to estimate left ventricular end-diastolic pressure (LVEDP) noninvasively by tissue Doppler imaging and color M-mode echocardiography. MATERIAL AND METHODS: We studied 3 groups of patients who were proven by angiography to be free of significant coronary artery lesions (<40% stenosis) with an LVEDP < 10 mm Hg (group A: n = 24; 16 men, 18 women; mean age +/- SD = 55 +/- 13 years), an LVEDP of 10 to 15 mm Hg (group B: n = 21; 17 men, 4 women; mean age 56 +/- 11 years), or an LVEDP > 15 mm Hg (group C: n = 35; 20 men, 15 women; mean age 58 +/- 9 years). Tissue Doppler imaging of the lateral mitral annulus and color M-mode imaging of the mitral valve in the apical 4-chamber view were obtained with an echocardiographic system. Early and late diastolic velocities (Em and Am, respectively), Em deceleration time (EmDT), Am time (Am-t), and mitral propagation velocity time delay (VpDT) were measured in each patient. RESULTS: In group A, sensitivity and specificity for EmDT < or = 100 ms, Am-t < or = 90 ms, Em/Am > or = 1, and VpDT < or = 45 ms were found to be 0.57 and 0.89, 0.66 and 0.88, 0.86 and 0.92, and 0.73 and 0.89, respectively. In group B, sensitivity and specificity for EmDT 100 to 120 ms, Am-t 90 to 110 ms, Em/Am 1 to 0.5, and VpDT 45 to 60 ms were found to be 0.57 and 0.84, 0.69 and 0.82, 0.66 and 0.75, and 0.55 and 0.83, respectively. In group C, sensitivity and specificity for EmDT > 120 ms, Am-t > 110 ms, Em/Am < 0.5, and VpDT > 60 ms were found to be 0.88 and 0.81, 0.71 and 0.80, 0.86 and 0.72, and 0.78 and 0.86, respectively. CONCLUSION: The EmDT, Am-t, Em/Am, and VpDT measurements obtained noninvasively by left ventricular tissue Doppler imaging and mitral flow propagation velocity were found to be useful in the estimation of LVEDP.


Assuntos
Ecocardiografia Doppler em Cores , Disfunção Ventricular Esquerda/diagnóstico por imagem , Disfunção Ventricular Esquerda/fisiopatologia , Função Ventricular Esquerda , Pressão Ventricular , Adulto , Idoso , Velocidade do Fluxo Sanguíneo , Diástole , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Sensibilidade e Especificidade
17.
Acta Orthop Belg ; 67(3): 259-66, 2001 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-11486689

RESUMO

The authors present the results of a retrospective review of popliteal artery injuries associated with fractures and dislocations about the knee. They treated 41 patients with popliteal artery injuries associated with either fractures about the knee or knee dislocations. Thirty-five of the patients were males, 6 females; the mean age was 23 years. The delay before accessing the hospital was 17 hours (range: 3 hours to 10 days). Thirty-two fractures were open. Together with the vascular injury, 12 femoral fractures, 20 tibial and fibular fractures, 5 knee dislocations, 4 femoral + tibial fractures were identified. Twenty-three patients underwent external fixation, 8 internal fixation, 6 plaster cast immobilization, 4 minimal osteosynthesis and plaster cast immobilization. The arterial injury was treated by end-to-end anastomosis in 5 cases, saphenous vein anastomosis in 29 cases and thrombectomy in 7 cases. Nine patients were amputated. Delay in surgery, blunt trauma, extensive soft tissue defect and bone fracture or dislocation, are associated with high amputation rate following popliteal artery injury. The influence of each of these factors alone on the amputation rate could not be evaluated in this study, as no statistically significant correlation could be demonstrated.


Assuntos
Amputação Cirúrgica/estatística & dados numéricos , Fraturas Fechadas/complicações , Luxações Articulares/complicações , Traumatismos do Joelho/complicações , Artéria Poplítea/lesões , Adolescente , Adulto , Idoso , Moldes Cirúrgicos , Criança , Pré-Escolar , Fixadores Externos , Feminino , Humanos , Fixadores Internos , Articulação do Joelho/irrigação sanguínea , Articulação do Joelho/patologia , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Tempo
18.
Cardiovasc Pathol ; 10(3): 147-9, 2001.
Artigo em Inglês | MEDLINE | ID: mdl-11485860

RESUMO

Primary pericardial mesothelioma is an extremely rare tumor. This case illustrates the typical late presentation of primary pericardial mesothelioma with symptoms and signs of constrictive pericarditis. An unusual feature was the complete encasement of the heart by the tumor. No satisfactory treatment was available.


Assuntos
Neoplasias Cardíacas/complicações , Mesotelioma/complicações , Pericárdio , Adulto , Evolução Fatal , Neoplasias Cardíacas/patologia , Neoplasias Cardíacas/cirurgia , Humanos , Masculino , Mesotelioma/patologia , Mesotelioma/cirurgia , Miocárdio/patologia , Derrame Pericárdico/etiologia , Derrame Pericárdico/cirurgia , Pericardite/etiologia
19.
Chest ; 114(1): 160-5, 1998 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-9674464

RESUMO

STUDY OBJECTIVE: To evaluate the role of intrapleural fibrinolytic treatment (IPFT) in traumatic clotted hemothorax. DESIGN AND PATIENTS: Between August 1995 and February 1997, 24 patients with traumatic clotted hemothorax were included. Streptokinase (SK), 250,000 IU, or urokinase (UK), 100,000 IU, diluted in 100 mL of saline solution was given daily. We administered 5.0+/-1.8 (range, 2 to 9) doses of SK or 6.25+/-5.97 (range, 2 to 15) doses of UK. SETTING: Dicle University School of Medicine, Thoracic and Cardiovascular Surgery Department. RESULTS: Complete response, which was defined as resolution of symptoms with complete drainage of fluid and no residual space radiographically, occurred in 15 (62.5%) patients. Partial response, which was defined as resolution of symptoms with a small pleural cavity, occurred in seven (29.2%) patients. Two patients (8.3%) required decortication; they were defined as nonresponders. The mean period of time between the diagnosis and fibrinolytic treatment (FT) was 11.65+/-6.38 (range, 4 to 25) days. There were no complications related to IPFT. There was no mortality during the course of IPFT. CONCLUSION: The use of intrapleural fibrinolytic agents has resulted in resolution of clotted hemothorax with an overall success rate of 91.7%. We recommend that IPFT should be added to the algorithm for management of clotted hemothorax before proceeding with minithoracotomy or pleural decortication.


Assuntos
Fibrinolíticos/uso terapêutico , Hemotórax/tratamento farmacológico , Traumatismos Torácicos/complicações , Terapia Trombolítica , Trombose/tratamento farmacológico , Adolescente , Adulto , Algoritmos , Criança , Drenagem , Estudos de Avaliação como Assunto , Feminino , Fibrinolíticos/administração & dosagem , Seguimentos , Hemotórax/etiologia , Humanos , Injeções , Masculino , Microcirurgia , Pessoa de Meia-Idade , Ativadores de Plasminogênio/administração & dosagem , Ativadores de Plasminogênio/uso terapêutico , Pleura/cirurgia , Indução de Remissão , Estreptoquinase/administração & dosagem , Estreptoquinase/uso terapêutico , Toracotomia , Trombose/etiologia , Fatores de Tempo , Resultado do Tratamento , Ativador de Plasminogênio Tipo Uroquinase/administração & dosagem , Ativador de Plasminogênio Tipo Uroquinase/uso terapêutico
20.
Eur Radiol ; 8(4): 571-2, 1998.
Artigo em Inglês | MEDLINE | ID: mdl-9569324

RESUMO

This article presents a patient with portal hypertension in whom an unusual localization for portosystemic collaterals have incidentally been found. Upper abdominal sonography revealed tubular structures filling the whole perirenal and partially the perihepatic area, and their venous nature was demonstrated with duplex Doppler sonography. Spiral CT angiography identified the right-sided retroperitoneal location and mesenteric-lumbar route of the collaterals. Upper gastrointestinal endoscopy with antral biopsy and percutaneous liver biopsy were performed. Laboratory results and specimen evaluation revealed chronic active hepatitis due to hepatitis-B infection. Attention is drawn to the abnormal location of these vessels, together with the noninvasive nature and competence of CT angiography in demonstrating vascular pathologies.


Assuntos
Angiografia , Varizes Esofágicas e Gástricas/diagnóstico por imagem , Sistema Porta/diagnóstico por imagem , Tomografia Computadorizada por Raios X , Adulto , Circulação Colateral , Varizes Esofágicas e Gástricas/etiologia , Hepatite B Crônica/complicações , Hepatite B Crônica/diagnóstico , Humanos , Hipertensão Portal/complicações , Hipertensão Portal/diagnóstico , Masculino , Neovascularização Patológica/diagnóstico por imagem , Neovascularização Patológica/patologia , Fluxo Sanguíneo Regional , Ultrassonografia Doppler Dupla
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