RESUMO
To estimate the ability of cycloferon to influence a microbiological landscape of tonsils surface in often ill children (OIC), the microflora of tonsils before and after a standard course of this preparation in a group of 68 preschool children classified into OIC category. It is established that the microbe landscape of tonsils surface after a course of cycloferon therapy is characterized by reduction of microflora variety, decrease in bacteria titer (including S. aureus), and reduction ion then number of strains resistant to benzylpenicillin, clindamycin, and vancomycin. Thus, it is possible to recommend cycloferon for rehabilitation of OIC.
Assuntos
Acridinas/administração & dosagem , Farmacorresistência Bacteriana/efeitos dos fármacos , Indutores de Interferon/administração & dosagem , Tonsila Palatina/microbiologia , Infecções Estafilocócicas , Anti-Infecciosos/farmacologia , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Staphylococcus aureus/crescimento & desenvolvimento , Staphylococcus aureus/isolamento & purificaçãoRESUMO
The article assesses the effectiveness of administering immunomodulating drug cycloferon in patients aged 10 to 16 years with chronic gastroduodenitis. It is established that the use of cycloferon in children with virus-associated chronic gastroduodenitis leads to a significant increase in T- and B-lymphocyte populations in mucous membranes of the stomach and duodenum, and contributes to the elimination of viruses. This results in reduced severity and activity of inflammation in the mucous membranes and decreases clinical manifestations of the disease.
Assuntos
Acridinas/uso terapêutico , Citomegalovirus/efeitos dos fármacos , Duodenite/tratamento farmacológico , Gastrite/tratamento farmacológico , Herpesvirus Humano 4/efeitos dos fármacos , Fatores Imunológicos/uso terapêutico , Papillomaviridae/efeitos dos fármacos , Adolescente , Antígenos Virais/sangue , Linfócitos B/imunologia , Proliferação de Células , Criança , Doença Crônica , Citomegalovirus/imunologia , Duodenite/diagnóstico , Duodenite/imunologia , Duodenite/virologia , Duodeno/efeitos dos fármacos , Duodeno/imunologia , Duodeno/virologia , Feminino , Gastrite/diagnóstico , Gastrite/imunologia , Gastrite/virologia , Herpesvirus Humano 4/imunologia , Humanos , Ativação Linfocitária , Masculino , Papillomaviridae/imunologia , Estômago/efeitos dos fármacos , Estômago/imunologia , Estômago/virologia , Linfócitos T/imunologia , Resultado do TratamentoRESUMO
Two hundred fifty patients, including 100 children with frequent and prolonged diseases at the age of 4 to 7 years, 76 children at the age of 7 to 18 years and 74 subjects at the age of 22 to 57 years were observed. The patients were treated with cycloferon in two courses with a 2-week interval according to the standard scheme. The tonsil surface microflora and its susceptibility to antibiotics were determined. Cycloferon lowered the Staphylococcus aureus titre and increased the culture susceptibility to benzylpenicillin, oxacillin, rifampicin, and erythromycin, reducing the variety of the fauces nonpathogenic microflora. The use of cycloferon induced no adverse (pathologic) reactions in 94.8% of the cases. In 4.4% of the children under school age the adverse reactions were transitory and did not require discontinuation of the drug use. Unforeseen reactions were recorded in 0.8% of the children and the use of the drug in them was discontinued. The use of cycloferon in two courses with a 2-week interval according to the standard scheme is recommended for prophylaxis of acute respiratory diseases in the group of children with frequent and prolonged diseases during epidemiologically unfavourable periods and for complex therapy of rhinopharinx infections as an agent increasing efficacy of other antibacterials.