RESUMO
Dermatomyositis (DM) is a systemic autoimmune disorder characterized by proximal myopathy and dermatological findings. Approximately 15-30% of DM cases emerge as a paraneoplastic syndrome caused by a concomitant malignancy. Although more rare, in cancer patients DM has also been reported as a possible result of toxicity of some antineoplastic agents, such as taxanes and monoclonal antibodies. Herein, we report a 35-year-old woman with metastatic breast cancer who presented with skin lesions after initiation of paclitaxel and anti-HER2 agents. Clinical, laboratory, and histological findings were consistent with the diagnosis of DM.
Assuntos
Neoplasias da Mama , Dermatomiosite , Feminino , Humanos , Adulto , Anticorpos Monoclonais , Autoanticorpos , PaclitaxelRESUMO
Myopericytoma is an uncommon benign neoplasm that arises from the perivascular myoid cells. It typically presents as a painless well-circumscribed cutaneous or soft-tissue nodule, most commonly on the extremities of adults. Histologically, it is characterized by spindle-shaped myoid-appearing cells with a concentric arrangement in vessel walls, that are immunoreactive to alpha-smooth muscle actin and often for h-caldesmon, but negative for other smooth muscle markers. Herein, we present an unusual case of a painful subungual myopericytoma presenting as a dark subungual discoloration.
Assuntos
Hemangiopericitoma , Miopericitoma , Doenças da Unha , Adulto , Hemangiopericitoma/patologia , Humanos , Miopericitoma/patologia , Doenças da Unha/diagnóstico , Doenças da Unha/patologia , Pericitos/patologia , Pele/patologiaRESUMO
A 76-year-old woman presented to the medical oncology outpatient clinic with painful, burning, pruritic erythematous plaques involving both palms and axillae that had suddenly appeared five days before. Examination revealed no additional relevant findings and laboratory studies did not show any alteration. The patient had been recently diagnosed with a high-grade angiosarcoma of the breast (probably radiation induced) and after frequent local recurrences, was being treated with liposomal doxorubicin (three cycles were administered, the last of which was seven days before the appearance of the mentioned lesions). Oral corticosteroids were started, treatment with liposomal doxorubicin was stopped, and cutaneous biopsies performed that revealed features compatible with toxic erythema of chemotherapy induced by liposomal doxorubicin. Complete resolution of the cutaneous lesions was verified one month after. No signs of recurrence of angiosarcoma were documented at follow-up three months later.
Assuntos
Antineoplásicos , Hemangiossarcoma , Idoso , Doxorrubicina/efeitos adversos , Doxorrubicina/análogos & derivados , Eritema/induzido quimicamente , Feminino , Humanos , PolietilenoglicóisAssuntos
Adenocarcinoma/tratamento farmacológico , Anticorpos Monoclonais/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Toxidermias/patologia , Hemangioma/induzido quimicamente , Neoplasias Gástricas/tratamento farmacológico , Adenocarcinoma/patologia , Idoso , Anticorpos Monoclonais/administração & dosagem , Anticorpos Monoclonais Humanizados , Exantema/induzido quimicamente , Exantema/patologia , Hemangioma/patologia , Humanos , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Hepáticas/secundário , Masculino , Paclitaxel/administração & dosagem , Neoplasias Peritoneais/tratamento farmacológico , Neoplasias Peritoneais/secundário , Neoplasias Gástricas/patologia , Suspensão de Tratamento , RamucirumabAssuntos
Alopurinol/efeitos adversos , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Cladribina/efeitos adversos , Toxidermias/fisiopatologia , Exantema/induzido quimicamente , Leucemia de Células Pilosas/tratamento farmacológico , Transtornos da Pigmentação/induzido quimicamente , Transtornos da Pigmentação/tratamento farmacológico , Púrpura/induzido quimicamente , Púrpura/tratamento farmacológico , Idoso , Alopurinol/uso terapêutico , Antimetabólitos Antineoplásicos/efeitos adversos , Antimetabólitos Antineoplásicos/uso terapêutico , Antineoplásicos/efeitos adversos , Antineoplásicos/uso terapêutico , Cladribina/uso terapêutico , Toxidermias/prevenção & controle , Monitoramento de Medicamentos , Exantema/fisiopatologia , Exantema/prevenção & controle , Humanos , Masculino , Transtornos da Pigmentação/fisiopatologia , Transtornos da Pigmentação/prevenção & controle , Púrpura/fisiopatologia , Púrpura/prevenção & controle , Índice de Gravidade de Doença , Resultado do TratamentoAssuntos
Carcinoma de Células Renais/tratamento farmacológico , Indóis/efeitos adversos , Neoplasias Renais/tratamento farmacológico , Doenças da Unha/induzido quimicamente , Transtornos da Pigmentação/induzido quimicamente , Pirróis/efeitos adversos , Idoso , Carcinoma de Células Renais/diagnóstico , Carcinoma de Células Renais/cirurgia , Feminino , Seguimentos , Humanos , Indóis/uso terapêutico , Neoplasias Renais/diagnóstico , Neoplasias Renais/cirurgia , Doenças da Unha/diagnóstico , Transtornos da Pigmentação/diagnóstico , Pirróis/uso terapêutico , Medição de Risco , SunitinibeAssuntos
Caquexia/etiologia , Úlcera Cutânea/etiologia , Tuberculose Cutânea/diagnóstico , Adolescente , Antituberculosos/uso terapêutico , Quimioterapia Combinada , Humanos , Masculino , Úlcera Cutânea/tratamento farmacológico , Tuberculose Cutânea/complicações , Tuberculose Cutânea/tratamento farmacológico , Tuberculose Pulmonar/complicações , Tuberculose Pulmonar/diagnóstico , Tuberculose Pulmonar/tratamento farmacológicoRESUMO
Depilation techniques have gain popularity in the last few decades. Nowadays there are available a wide variety of lasers as well as intense pulsed light for depilation. However, little is known about the long-term effects of these procedures when melanocytic nevi are affected by them. We report the cases of three patients where we observed clinical, dermoscopic and histopathological changes secondary to laser therapy and intense pulsed light depilation, respectively. We believe that it is necessary to perform further studies to prove the absence of malignant transformation so that we will be able to set up recommendations in those patients with a personal or family history of malignant melanoma and/or dysplastic nevi.
Assuntos
Remoção de Cabelo/instrumentação , Terapia com Luz de Baixa Intensidade/instrumentação , Nevo Pigmentado/patologia , Remoção de Cabelo/efeitos adversos , Humanos , Terapia com Luz de Baixa Intensidade/efeitos adversos , Masculino , Pessoa de Meia-IdadeRESUMO
Human leishmaniasis produced by Leishmania infantum is endemic in Mediterranean countries. In the context of a leishmaniasis outbreak in the town of Fuenlabrada, Madrid, Spain, we had two patients with cutaneous leishmaniasis that developed non-necrotizing cutaneous granulomas. They had both been receiving anti-TNF treatment with adalimumab for rheumatic diseases. Neither of them developed visceral disease and did not require anti-TNF treatment withdrawal to control the cutaneous disease. It is well known that anti-TNF therapy is associated with opportunistic diseases, especially with those in which granuloma formation is an important part of the host defence, as in tuberculosis. We think that granuloma formation through activation of Toll-like receptor-9 and via induction of a Th17 response may be precipitated by the parasites in the dermis.