RESUMO
OBJECTIVES: Pressure ulcers impose a major lifetime medical problem to patients with high-grade spinal cord injury (SCI). For patients with stages 3-4 pressure ulcers, plastic surgery is often the only remaining treatment option. Despite considerable flap failure rates of around 30%, only sparse knowledge exists on predictors for flap failure. Hence, identification of predictors for flap failures is needed. METHODS: We prospectively enrolled 38 SCI patients with stages 3-4 pressure ulcers scheduled for plastic surgery. Preoperative wound swabs, intraoperative tissue samples and postoperative drainage liquids were microbiologically analyzed. In multivariable logistic regression analyses, bacterial loads of deep tissue cultures of intraoperative samples as well as other clinical variables were analyzed with respect to the prediction of flap failures. RESULTS: The flap failure rate was 27.5%. Bacterial loads of deep tissue cultures were not predictive for flap failure, neither was the colonization with a specific bacterial strain. We observed a considerable fluctuation of microbiological environment from initial swab cultures, intraoperative samples and postoperative drainage fluids. Antibioprophylaxis was sufficient in only 75% of deep tissue cultures and 69% of drainage fluids. Insufficient antibioprophylaxis was associated with a higher flap failure rates (odds ratio 6.3, confidence interval 1.2-41.0). CONCLUSION: After inpatient wound conditioning, bacterial load analysis of intraoperative wound tissue cultures is ineffective in order to predict flap failure rates in SCI patients with stages 3-4 pressure ulcers after flap surgery. Instead, insufficient antibioprophylaxis might be a factor contributing to flap failure.
Assuntos
Procedimentos de Cirurgia Plástica , Úlcera por Pressão/microbiologia , Úlcera por Pressão/cirurgia , Traumatismos da Medula Espinal/complicações , Retalhos Cirúrgicos , Adulto , Idoso , Carga Bacteriana , Biomarcadores/sangue , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Razão de Chances , Complicações Pós-Operatórias/sangue , Complicações Pós-Operatórias/diagnóstico , Complicações Pós-Operatórias/microbiologia , Úlcera por Pressão/diagnóstico , Úlcera por Pressão/etiologia , Prognóstico , Estudos Prospectivos , Traumatismos da Medula Espinal/sangue , Traumatismos da Medula Espinal/microbiologia , Traumatismos da Medula Espinal/cirurgia , Fatores de Tempo , Falha de TratamentoRESUMO
Spinal cord injuries often occur in cases of multiple trauma, can occur alone or in combination with concomitant injuries and are mostly associated with high morbidity and mortality. They often result in lifelong impairment and need for medical care. Radiologic diagnostics are crucial in the acute setting as well as in the long-term treatment of spinal cord injuries. Besides an overview of diagnostic and therapeutic management, typical magnetic resonance imaging (MRI) findings in the acute and chronic stages of spinal cord injuries are presented in this article. Post-traumatic syringomyelia can even develop years after the initial injury of the spine or spinal cord. As syringomyelia can also occur in association with tumors, developmental anomalies and also idiopathically, a thorough MRI diagnostic is essential especially in any case of newly diagnosed syringomyelia.
Assuntos
Aumento da Imagem/métodos , Imageamento por Ressonância Magnética/métodos , Traumatismos da Medula Espinal/complicações , Traumatismos da Medula Espinal/diagnóstico , Medula Espinal/patologia , Siringomielia/diagnóstico , Siringomielia/etiologia , Diagnóstico Diferencial , HumanosRESUMO
BACKGROUND AND PURPOSE: Pressure sores are a major health problem in spinal cord injury (SCI). In this population pressure damage to peripheral nerves was not thoroughly investigated so far. However, intact peripheral nerves and innervated muscles are a prerequisite for the effectiveness of supportive therapies like functional electrical stimulation (FES). METHODS: We assessed electroneurographic (ENG) data of lower limbs in SCI individuals admitted to our hospital due to severe pressure sores. Our centers prospectively acquired ENG data of the European Multicenter study about SCI (EMSCI) patients served as early control. RESULTS: In the pressure sore cohort (n = 15) all patients were sensory-motor complete (American Spinal Cord Injury Association Impairment Scale A). Most patients (10/15) suffered from a severe axonal sensory-motor polyneuropathy in paralysed legs with absent compound muscle action potentials (CMAPs) of tibial/peroneal nerves as well as absent sensory nerve action potentials of sural nerves. The onset of this polyneuropathy dates within the first year after incident SCI and was mainly associated with increasing sensory-motor completeness as demonstrated by a significant CMAP drop of our centers EMSCI-ENG data on serial tibial nerve recordings in 275 patients. CONCLUSIONS: Severe SCI is associated with an early-onset axonal polyneuropathy in paralysed limbs to which pressure damage might contribute. Because intact peripheral nerves are required for: (i) maintenance of motor function in centrally impaired muscles; and (ii) effectiveness of supportive therapies like FES, ENG-monitoring could serve as a low invasive screening method for peripheral nerve integrity in patients with SCI to initiate pressure relief procedures early enough.
Assuntos
Extremidade Inferior/fisiopatologia , Paralisia/complicações , Doenças do Sistema Nervoso Periférico/complicações , Traumatismos da Medula Espinal/complicações , Potenciais de Ação/fisiologia , Estudos de Casos e Controles , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Condução Nervosa/fisiologia , Paralisia/fisiopatologia , Doenças do Sistema Nervoso Periférico/fisiopatologia , Úlcera por Pressão/complicações , Úlcera por Pressão/fisiopatologia , Traumatismos da Medula Espinal/fisiopatologiaRESUMO
BACKGROUND: There is presently still no consensus on how to operatively treat adolescent idiopathic scoliosis (AIS), i.e. a clearly reduced thoracic kyphosis. For a long time the primary focus was mostly on correcting the coronal plane while neglecting the sagittal profile. Based on the current literature and own retrospective data a comprehensive review will be given on the optimal correction of the spine and how to avoid secondary complications. Different operative standard procedures are demonstrated with special attention to the sagittal balance and the special parameters sagittal vertical axis (SVA), lumbar lordosis (LL), thoracic kyphosis (TK), pelvic tilt (PT), sagittal slope (SSL) and pelvic incidence (PI). RESULTS: A total of 24 patients (2 groups of 12 patients) with AIS and posterior fusion with (group A) and without (group B) additional osteotomy were analyzed with respect to the impact on spinopelvic balance and health-related quality of life (HRQoL) parameters. Patients in group A had a significant reduction of TK, LL and SSL and an increase in PT whereas patients in group B showed the opposite. Correlation analysis revealed a significant dependence of HRQoL on PT. DISCUSSION: Both the results from the literature and own data confirm that operative correction of AIS needs a careful planning including sagittal spinopelvic parameters. Rigid thoracic hypokyphosis require additional osteotomy.
Assuntos
Cifose/cirurgia , Equilíbrio Postural/fisiologia , Escoliose/cirurgia , Fusão Vertebral/métodos , Adolescente , Fenômenos Biomecânicos/fisiologia , Criança , Terapia Combinada , Simulação por Computador , Feminino , Humanos , Cifose/diagnóstico por imagem , Cifose/fisiopatologia , Masculino , Osteotomia/métodos , Pelve/diagnóstico por imagem , Pelve/fisiopatologia , Pelve/cirurgia , Complicações Pós-Operatórias/diagnóstico por imagem , Complicações Pós-Operatórias/fisiopatologia , Qualidade de Vida , Radiografia , Estudos Retrospectivos , Escoliose/diagnóstico por imagem , Escoliose/fisiopatologia , Cirurgia Assistida por ComputadorRESUMO
Despite modern diagnostic imaging options pyogenic infections of the spine are often detected tardily and therefore accompanied by a high mortality rate. To ensure an efficient and adequate therapy it is necessary to identify and treat the focus of inflammation. The recommendations for the operative strategy are still a highly controversial issue. On the other hand no classification and guidelines for surgical treatment and treatment strategies of pyogenic spinal infection have yet been published.Pyogenic spinal infections are often underestimated in frequency of occurrence and severity of symptoms. From 1994 until 2008, 269 patients suffering from an infection of the thoracic and lumbar spine were treated in the Department of Orthopedic Surgery Heidelberg and 221 patients underwent surgery. Within the scope of a clinical trial clinical aspects and therapeutic consequences of patients with pyogenic spinal infections were retrospectively investigated. Based on the study data a classification of pyogenic spinal infections of the thoracic and lumbar spine and a guide for surgical decision-making was developed.
Assuntos
Abscesso/cirurgia , Infecções Bacterianas/cirurgia , Discite/cirurgia , Vértebras Lombares/cirurgia , Vértebras Torácicas/cirurgia , Abscesso/classificação , Abscesso/diagnóstico , Adulto , Idoso , Algoritmos , Infecções Bacterianas/classificação , Infecções Bacterianas/diagnóstico , Transplante Ósseo , Ensaios Clínicos como Assunto , Estudos Transversais , Desbridamento , Árvores de Decisões , Descompressão Cirúrgica , Avaliação da Deficiência , Discite/classificação , Discite/diagnóstico , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Pessoa de Meia-Idade , Exame Neurológico , Implantação de Prótese , Estudos Retrospectivos , Fatores de Risco , Fusão Vertebral , Tomografia Computadorizada por Raios XRESUMO
BACKGROUND: Degeneration of the upper adjacent segment after operative treatment of degenerative spinal diseases of the lumbar spine (degenerative disc disease DDD) is an unsolved problem. There is also no consensus on whether a rigid or dynamic treatment of DDD should be carried out to protect the segments. This study was carried out to evaluate the effect of bisegmental rigid 360° fusion and bisegmental hybrid fusion on the treated segment as well as on the upper adjacent segment under the aspect of segment protection. MATERIAL AND METHODS: A total of six human spinal column preparations (L2-5) were tested under native conditions (NAT), with bisegmental rigid fusion (RIG 360°) and with hybrid fusion (Hybrid) in all three movement directions under physical load and with an preload. The range of motion (ROM) and neutral zone (NZ) were evaluated. The intradiscal pressure (IDP) was measured in the upper adjacent segment (OAS). RESULTS: The RIG 360° led to a significant reduction in movement in all directions compared to NAT but Hybrid only in lateral bending (LB). In the OAS the NZ was showed a much greater increase than the ROM. The RIG 360° showed an increase of the NZ in flexion-extension of 86.8% and in LB of 49.6% as well as a significant increase in axial rotation of 52.5%. The increase in the Hybrid was not significant compared to NAT in all directions. Pressure measurements in OAS showed no significant differences for RIG 360° and for Hybrid compared to NAT for both load scenarios. DISCUSSION: The range of motion of the treated segments for Hybrid were close to NAT in comparison to RIG 360° indicating a segment-protective effect. The hypothesis that rigid fusion has a significant effect on intersegmental mobility and the increase in intradiscal pressure in the upper adjacent segment could not be confirmed. The data indicate that the primary effect of fusion on the adjacent segment is very low but the fusion-linked increased frequency of extreme loads of the OAS falling within the significance level leads to degeneration. Even if the NZ values for Hybrid and RIG 360° do not significantly differ from NAT, the NZ alterations between the instrumentations tend to be strongly shifted in favor of Hybrid. CONCLUSIONS: The data confirm that the clear and sometimes significant alterations of the NZ can be an essential factor for development of adjacent segment degeneration. A dynamic conclusion of instrumentation in the sense of a topping-off would appear to be useful if pathoanatomical indications for an intervertebral disc prosthesis are present.
Assuntos
Instabilidade Articular/fisiopatologia , Instabilidade Articular/cirurgia , Vértebras Lombares/fisiopatologia , Vértebras Lombares/cirurgia , Modelos Biológicos , Fusão Vertebral/instrumentação , Fusão Vertebral/métodos , Simulação por Computador , Desenho Assistido por Computador , Módulo de Elasticidade , Análise de Falha de Equipamento , Análise de Elementos Finitos , Humanos , Instabilidade Articular/diagnóstico , Desenho de Prótese , Articulação Zigapofisária/fisiopatologia , Articulação Zigapofisária/cirurgiaRESUMO
STUDY DESIGN: Clinical cohort study. OBJECTIVE: To evaluate if the impact of the severity of the trauma as a possible confounding factor influences the neurological and functional recovery in paraplegia during the course of a 6-month follow-up period after injury. SETTING: Spinal Cord Injury Center, Heidelberg University Hospital, Germany. METHODS: A retrospective monocentric analysis, from 2002 to 2008, of the Heidelberg European Multicenter Study about spinal cord injury database was performed. We included 31 paraplegic patients (neurological level T1-T12) who were assigned either to a monotrauma (polytraumaschluessel (PTS) 1) or to a polytrauma (PTS≥2) group. The American Spinal Injury Association Impairment Scale, lower extremity motor score, pin prick, light touch and the spinal cord independence measure (SCIM) were obtained at five distinct time points after trauma. Data were analyzed using Mann-Whitney U-test (α<0.05). RESULTS: The changes in lower extremity motor score, pin prick and light touch showed no significant differences in both groups over the whole evaluation period. Polytraumatic paraplegics showed a significantly delayed increase of SCIM between 2 and 6 weeks compared with monotraumatic patients, followed by a quantitative increase in the subitems bladder management, bowel management, use of toilet and prevention of pressure sores between 3 and 6 months (P=0.031). The mean length of primary rehabilitation in the polytrauma group was 5.5 vs 3.6 months in monotrauma. CONCLUSIONS: The prognosis of polytraumatic paraplegics in terms of neurological recovery is not inferior to those with monotrauma. Multiple-injured patients need a prolonged hospital stay to reach the functional outcome of monotraumatic patients.
Assuntos
Traumatismo Múltiplo/epidemiologia , Paraplegia/epidemiologia , Traumatismos da Medula Espinal/epidemiologia , Adulto , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Paraplegia/fisiopatologia , Paraplegia/reabilitação , Estudos Retrospectivos , Traumatismos da Medula Espinal/fisiopatologia , Traumatismos da Medula Espinal/reabilitação , Resultado do Tratamento , Adulto JovemRESUMO
BACKGROUND: The conservative and surgical management of lumbar kyphosis is difficult and is a challenge for the orthopaedic surgeon. A kyphotic deformity of the lumbar spine is present in 8% to 20% of these patients. Most curves have very rigid components, often exceed 80 degrees at birth. The options for conservative management are limited. Bracing is extremely difficult, rarely effective, and in advanced stages impossible. We have been using the Warner and Fackler kyphectomy technique at our institution since 1994 as a standard procedure for treating children with lumbar kyphosis due to myelomeningocele. RESULTS: This study was performed for a better understanding of the cause of the complications and optimizing the surgical technique. AIM: The aim of this study was to evaluate the longterm results, technical problems, early and late complications and the complication associated risk factors.
Assuntos
Cifoplastia/estatística & dados numéricos , Cifose/epidemiologia , Cifose/cirurgia , Meningomielocele/epidemiologia , Meningomielocele/cirurgia , Complicações Pós-Operatórias/epidemiologia , Adolescente , Adulto , Comorbidade , Feminino , Alemanha/epidemiologia , Humanos , Incidência , Cifose/diagnóstico por imagem , Estudos Longitudinais , Vértebras Lombares/cirurgia , Masculino , Meningomielocele/diagnóstico por imagem , Complicações Pós-Operatórias/diagnóstico por imagem , Radiografia , Medição de Risco/métodos , Fatores de Risco , Resultado do Tratamento , Adulto JovemRESUMO
BACKGROUND: The functions of synthetic bone graft substitutes include not only structural support to provide bone healing and osseous ingrowth but also the ability to serve as a local antibiotic delivery system to prevent or treat infections of the spine. MATERIAL AND METHODS: The impregnation and antibiotic efficiency of gentamicin and levofloxacin with Healos was investigated in vitro and compared with Healos without an antibiotic additive. These antibiotic-loaded bone graft substitutes were examined without dilution and with 10-fold and 100-fold dilution for activity against spondylodiscitis-causing bacteria on different agar plates using an agar diffusion method. RESULTS: All hydroxyapatite (HA)/collagen-saturated diluted antibiotics showed elliptical inhibition zones on the corresponding agar plates. For both antibiotics, there was a linear correlation between dilution and area of the inhibition zone. CONCLUSION: The analysis showed that the antimicrobial activity of HA/collagen-saturated antibiotics corresponded to the antimicrobial dilutions. These results should be further analyzed using in vivo studies to determine the remaining antibiotic efficiency after implantation of bone graft substitutes.
Assuntos
Antibacterianos/administração & dosagem , Substitutos Ósseos , Colágeno , Durapatita , Escherichia coli/efeitos dos fármacos , Gentamicinas/administração & dosagem , Levofloxacino , Testes de Sensibilidade Microbiana , Ofloxacino/administração & dosagem , Staphylococcus aureus/efeitos dos fármacos , Streptococcus pyogenes/efeitos dos fármacos , Relação Dose-Resposta a Droga , Humanos , Projetos PilotoRESUMO
STUDY DESIGN: Case report. OBJECTIVE: Complications in spinal cord injury (SCI) are a challenging problem for the patients and often difficult to manage. Three cases of spondylodiscitis, localized at the lumbosacral junction in long-term paraplegic patients are presented. SETTING: Spinal Cord Injury Center, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany. CLINICAL PRESENTATION: In all three cases, neurological deterioration (ASIA A) was caused by a secondary compression of the spinal cord at the lumbosacral spine. Increase of spasticity and pain, atonic bladder and sphincter function accompanied by vegetative symptoms were present in all patients. Microbiological analysis of the sacral area showed coagulase negative staphylococcus in two cases, whereas in one case no microorganism was found. The diagnosis was made by MRI of the whole spine and surgical treatment was required. At follow-up (6 months), patients showed no AIS (ASIA Impairment Scale) changes. CONCLUSION: If neurological deterioration occurs, spondylodiscitis should be ruled out in paraplegic individuals. The therapeutic goal is to achieve emergent decompression of the spinal cord and to administrate adequate antibiotic therapy to avoid a neurologically complete situation.
Assuntos
Discite , Paraplegia/complicações , Adulto , Discite/diagnóstico , Discite/etiologia , Discite/terapia , Humanos , Estudos Longitudinais , Imageamento por Ressonância Magnética/métodos , Masculino , Pessoa de Meia-Idade , Tomógrafos ComputadorizadosAssuntos
Doenças do Sistema Nervoso Autônomo/diagnóstico , Doenças do Sistema Nervoso Autônomo/fisiopatologia , Traumatismos da Medula Espinal/fisiopatologia , Medula Espinal/fisiopatologia , Sistema Nervoso Simpático/lesões , Sistema Nervoso Simpático/fisiopatologia , Doenças do Sistema Nervoso Autônomo/etiologia , Avaliação da Deficiência , Humanos , Doença dos Neurônios Motores/complicações , Doença dos Neurônios Motores/diagnóstico , Doença dos Neurônios Motores/fisiopatologia , Exame Neurológico/métodos , Sistema Nervoso Parassimpático/lesões , Sistema Nervoso Parassimpático/fisiopatologia , Valor Preditivo dos Testes , Reflexo Anormal/fisiologia , Reprodutibilidade dos Testes , Sensibilidade e Especificidade , Índice de Gravidade de Doença , Medula Espinal/patologia , Traumatismos da Medula Espinal/complicações , Vasoconstrição/fisiologia , Ferimentos e Lesões/complicaçõesRESUMO
We analysed the influence of the timing of surgery (< 48 hours, group 1, 21 patients vs > 48 hours, group 2, 14 patients) on the neurological outcome and restoration of mobility in 35 incomplete tetra- and paraplegic patients with metastatic spinal-cord compression. Pain and neurological symptoms were assessed using the American Spinal Injury Association impairment scale. More improvement was found in group 1 than in group 2 when comparing the pre-operative findings with those both immediately post-operatively (p = 0.021) and those at follow-up at four to six weeks (p = 0.010). In group 1 the number of pre-operatively mobile patients increased from 17 (81%) to 19 patients (90%) whereas the number of mobile patients in group 2 changed from nine (64%) to ten (71%). These results suggest that early surgical treatment in patients with metastatic spinal-cord compression gives a better neurological outcome even in a palliative situation.
Assuntos
Vértebras Cervicais/cirurgia , Descompressão Cirúrgica/métodos , Compressão da Medula Espinal/cirurgia , Neoplasias da Coluna Vertebral/cirurgia , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Dor Pós-Operatória/etiologia , Paraplegia/cirurgia , Paraplegia/terapia , Qualidade de Vida , Recuperação de Função Fisiológica , Estudos Retrospectivos , Compressão da Medula Espinal/etiologia , Neoplasias da Coluna Vertebral/secundário , Fatores de Tempo , Adulto JovemRESUMO
STUDY DESIGN: Case report. OBJECTIVE: To describe a rare case of paraplegia in a patient with Scheuermann's disease and dysplastic thoracic spinous processes. SETTING: Spinal Cord Injury Center, Orthopaedic University Hospital Heidelberg, Heidelberg, Germany. CLINICAL PRESENTATION: The authors report on a 15-year-old boy with progressive incomplete spastic paraplegia presenting segmental dysplastic thoracic spinous processes and Scheuermann's disease. The magnetic resonance imaging showed a kyphotic angulation at T 5/6 and signs of myelopathy. Hypoplastic thoracic processes and hypoplastic paraspinal muscles in the upper thoracic spine were observed intraoperatively. In this case, dorsoventral stabilization from T 4-7 was performed and the neurological outcome improved at follow-up (6 months). CONCLUSION: Paraplegia can be accelerated in patients with Scheuermann's disease, severe kyphotic angulation and dysplastic posterior elements. After operative treatment, neurological recovery and a normal walking pattern were shown.