The genetic variant SLC2A1 -rs1105297 is associated with the differential analgesic response to a glucose-based treatment in newborns.

ABSTRACT: Neonatal pain is a critical issue in clinical practice. The oral administration of glucose-based solutions is currently one of the most common and effective nonpharmacologic strategies for neonatal pain relief in daily minor procedures. However, a varying degree of analgesic efficacy has been reported for this treatment. Environmental, maternal, and genetic factors may explain this variability and potentially allow for a personalized analgesic approach, maximizing therapeutic efficacy and preventing side effects. We investigated the exposome (ie, the set of clinical and anthropometric variables potentially affecting the response to the therapy) and the genetic variability of the noradrenaline transporter gene (solute carrier family 6 member 2 [ SLC6A2 ]) and 2 glucose transporter genes (solute carrier family 2 member 1 [ SLC2A1 ] and 2 [ SLC2A2 ]) in relation to the neonatal analgesic efficacy of a 33% glucose solution. The study population consisted in a homogeneous sample of more than 1400 healthy term newborns. No association for the exposome was observed, whereas a statistically significant association between the G allele of SLC2A1 -rs1105297 and a fourfold decreased probability of responding to the therapy was identified after multiple-testing correction (odds ratio of 3.98, 95% confidence interval 1.95-9.17; P = 4.05 × 10 -4 ). This allele decreases the expression of SLC2A1-AS1 , causing the upregulation of SLC2A1 in the dorsal striatum, which has been suggested to be involved in reward-related processes through the binding of opioids to the striatal mu-opioid receptors. Altogether, these results suggest the involvement of SLC2A1 in the analgesic process and highlight the importance of host genetics for defining personalized analgesic treatments.

Artificial light at night: a global disruptor of the night-time environment.

Light pollution is the alteration of the natural levels of darkness by an increased concentration of light particles in the night-time environment, resulting from human activity. Light pollution is profoundly changing the night-time environmental conditions across wide areas of the planet, and is a relevant stressor whose effects on life are being unveiled by a compelling body of research. In this paper, we briefly review the basic aspects of artificial light at night as a pollutant, describing its character, magnitude and extent, its worldwide distribution, its temporal and spectral change trends, as well as its dependence on current light production technologies and prevailing social uses of light. It is shown that the overall effects of light pollution are not restricted to local disturbances, but give rise to a global, multiscale disruption of the night-time environment. This article is part of the theme issue 'Light pollution in complex ecological systems'.

Light pollution is skyrocketing.

Data from citizen scientists reveal a worrying growth in light pollution over the past decade.

Very important dark sky areas in Europe and the Caucasus region.

ALAN (artificial light at night) can give, if done adequately, a lot of benefits for human society, but it affects reproduction, navigation, foraging, habitat selection, communication, trophic and social interactions of the biota in the same time. Taking into account dramatic increase in light pollution of the night sky and night environment during the past decades, the creation of refugia where natural habitats are not influenced by ALAN is very important. We selected promising territories without, or with a low impact of, ALAN for the development of a VIDA (Very Important Dark Area) Network in Europe and the Caucasus region. 54 VIDAs within the borders of 30 countries were chosen, located in different biogeographic regions, at different altitudes, and in juxtaposition with protected areas. Special attention has been paid to sea and ocean islands, non-polluted by ALAN, as well as to large parts of European Russia and Kazakhstan where there is still a low level of light pollution. These places might be a basis for the protection of biodiversity from the consequences of ALAN, and they can also serve as key education centers for increasing the awareness of the problem of light pollution of the sky at night. Due to the fact that light propagates far away in the atmosphere, the protection of VIDAs can be obtained only if a strong anti-light pollution action is enforced also in the surrounding areas, at least 100 km from the borders of the VIDAs.

A linear systems approach to protect the night sky: implications for current and future regulations.

The persistent increase of artificial light emissions is causing a progressive brightening of the night sky in most regions of the world. This process is a threat for the long-term sustainability of the scientific and educational activity of ground-based astronomical observatories operating in the optical range. Huge investments in building, scientific and technical workforce, equipment and maintenance can be at risk if the increasing light pollution levels hinder the capability of carrying out the top-level scientific observations for which these key scientific infrastructures were built. Light pollution has other negative consequences, as e.g. biodiversity endangering and the loss of the starry sky for recreational, touristic and preservation of cultural heritage. The traditional light pollution mitigation approach is based on imposing conditions on the photometry of individual sources, but the aggregated effects of all sources in the territory surrounding the observatories are seldom addressed in the regulations. We propose that this approach shall be complemented with a top-down, ambient artificial skyglow immission limits strategy, whereby clear limits are established to the admissible deterioration of the night sky above the observatories. We describe the general form of the indicators that can be employed to this end, and develop linear models relating their values to the artificial emissions across the territory. This approach can be easily applied to other protection needs, like e.g. to protect nocturnal ecosystems, and it is expected to be useful for making informed decisions on public lighting, in the context of wider spatial planning projects.

Resources of dark skies in German climatic health resorts.

Illumination of nocturnal environments is increasing steadily worldwide. While there are some benefits for mankind, light at night affects animals, plants, and human health by blurring the natural distinction between day and night. International regulations exist to protect the environment for the maintenance of human health but nocturnal darkness is not considered. In Germany, cities and communities labeled as Climatic Health Resorts provide for high standards in air quality. However, their degree of nocturnal darkness is unexplored so far. In our study, we examined the degree of nocturnal darkness in German Climatic Health Resorts by two datasets based on georeferenced remote sensing data. The majority of Climatic Health Resorts (93.1 %) are able to offer a relative respite (≥ 20 mag/arcsec2) from a degraded nocturnal environment, while only 3.4 % are able to offer a dark, if by no means pristine, night environment (≥ 21 mag/arcsec2). Climatic Health Resorts emit less light as well as are less affected by night sky brightness compared to the average of non-classified communities. In combination with daytime requirements, the resorts provide conditions for a more distinct day-and-night-cycle than non-classified communities.

The new world atlas of artificial night sky brightness.

Artificial lights raise night sky luminance, creating the most visible effect of light pollution-artificial skyglow. Despite the increasing interest among scientists in fields such as ecology, astronomy, health care, and land-use planning, light pollution lacks a current quantification of its magnitude on a global scale. To overcome this, we present the world atlas of artificial sky luminance, computed with our light pollution propagation software using new high-resolution satellite data and new precision sky brightness measurements. This atlas shows that more than 80% of the world and more than 99% of the U.S. and European populations live under light-polluted skies. The Milky Way is hidden from more than one-third of humanity, including 60% of Europeans and nearly 80% of North Americans. Moreover, 23% of the world's land surfaces between 75°N and 60°S, 88% of Europe, and almost half of the United States experience light-polluted nights.

Worldwide variations in artificial skyglow.

Despite constituting a widespread and significant environmental change, understanding of artificial nighttime skyglow is extremely limited. Until now, published monitoring studies have been local or regional in scope, and typically of short duration. In this first major international compilation of monitoring data we answer several key questions about skyglow properties. Skyglow is observed to vary over four orders of magnitude, a range hundreds of times larger than was the case before artificial light. Nearly all of the study sites were polluted by artificial light. A non-linear relationship is observed between the sky brightness on clear and overcast nights, with a change in behavior near the rural to urban landuse transition. Overcast skies ranged from a third darker to almost 18 times brighter than clear. Clear sky radiances estimated by the World Atlas of Artificial Night Sky Brightness were found to be overestimated by ~25%; our dataset will play an important role in the calibration and ground truthing of future skyglow models. Most of the brightly lit sites darkened as the night progressed, typically by ~5% per hour. The great variation in skyglow radiance observed from site-to-site and with changing meteorological conditions underlines the need for a long-term international monitoring program.

Citizen science provides valuable data for monitoring global night sky luminance.

The skyglow produced by artificial lights at night is one of the most dramatic anthropogenic modifications of Earth's biosphere. The GLOBE at Night citizen science project allows individual observers to quantify skyglow using star maps showing different levels of light pollution. We show that aggregated GLOBE at Night data depend strongly on artificial skyglow, and could be used to track lighting changes worldwide. Naked eye time series can be expected to be very stable, due to the slow pace of human eye evolution. The standard deviation of an individual GLOBE at Night observation is found to be 1.2 stellar magnitudes. Zenith skyglow estimates from the "First World Atlas of Artificial Night Sky Brightness" are tested using a subset of the GLOBE at Night data. Although we find the World Atlas overestimates sky brightness in the very center of large cities, its predictions for Milky Way visibility are accurate.

Limiting the impact of light pollution on human health, environment and stellar visibility.

Light pollution is one of the most rapidly increasing types of environmental degradation. Its levels have been growing exponentially over the natural nocturnal lighting levels provided by starlight and moonlight. To limit this pollution several effective practices have been defined: the use of shielding on lighting fixture to prevent direct upward light, particularly at low angles above the horizon; no over lighting, i.e. avoid using higher lighting levels than strictly needed for the task, constraining illumination to the area where it is needed and the time it will be used. Nevertheless, even after the best control of the light distribution is reached and when the proper quantity of light is used, some upward light emission remains, due to reflections from the lit surfaces and atmospheric scatter. The environmental impact of this "residual light pollution", cannot be neglected and should be limited too. Here we propose a new way to limit the effects of this residual light pollution on wildlife, human health and stellar visibility. We performed analysis of the spectra of common types of lamps for external use, including the new LEDs. We evaluated their emissions relative to the spectral response functions of human eye photoreceptors, in the photopic, scotopic and the 'meltopic' melatonin suppressing bands. We found that the amount of pollution is strongly dependent on the spectral characteristics of the lamps, with the more environmentally friendly lamps being low pressure sodium, followed by high pressure sodium. Most polluting are the lamps with a strong blue emission, like Metal Halide and white LEDs. Migration from the now widely used sodium lamps to white lamps (MH and LEDs) would produce an increase of pollution in the scotopic and melatonin suppression bands of more than five times the present levels, supposing the same photopic installed flux. This increase will exacerbate known and possible unknown effects of light pollution on human health, environment and on visual perception of the Universe by humans. We present quantitative criteria to evaluate the lamps based on their spectral emissions and we suggest regulatory limits for future lighting.