Preoperative computed tomography enterography-based radiomics signature: A potential predictor of postoperative anastomotic recurrence in patients with Crohn's disease.

BACKGROUND: More than half of patients with Crohn's disease (CD) require at least one surgery for symptom management; however, approximately half of the patients may experience postoperative anastomotic recurrence (PAR). OBJECTIVES: This study aims to develop and validate a preoperative computed tomography enterography (CTE)-based radiomics signature to predict early PAR in CD. DESIGN: A total of 186 patients with CD (training cohort, n = 134; test cohort, n = 52) who underwent preoperative CTE and surgery between January 2014 and June 2020 were included in this retrospective multi-centre study. METHODS: 106 radiomic features were initially extracted from intestinal lesions and peri-intestinal mesenteric fat, respectively; significant radiomic features were selected from them and then used to develop intestinal or mesenteric radiomics signatures, using the least absolute shrinkage and selection operator and a Cox regression model. A radiomics-based nomogram incorporating these signatures with clinical-radiological factors was created for comparison with a model based on clinical-radiological features alone. RESULTS: 68 of 134 patients in training cohort and 16 of 52 patients in test cohort suffered from PAR. The intestinal radiomic signature (hazard ratio [HR]: 2.17; 95% confidence interval [CI]: 1.32-3.58; P = 0.002) and mesenteric radiomic signature (HR: 2.19; 95% CI: 1.14-4.19; P = 0.018) were independent risk factors for PAR in the training cohort as per a multivariate analysis. The radiomics-based nomogram (C-index: 0.710; 95% CI: 0.672-0.748) yielded superior predictive performance than the clinical-radiological model (C-index, 0.607; 95% CI: 0.582-0.632) in the test cohort. Decision curve analysis demonstrated that the radiomics-based nomogram outperformed the clinical-radiological model in terms of clinical usefulness. CONCLUSIONS: Preoperative mesenteric and intestinal CTE radiomics signatures are potential non-invasive predictors of PAR in postoperative patients with CD.

Hydrophobic deep eutectic solvents as green absorbents for hydrophilic VOC elimination.

As a common hydrophilic volatile organic compound (VOC), acetone is known to harm human health and the atmospheric environment. Absorption is a typical technique applied to capture hydrophilic VOCs; however, the difficulty of separating and recovering absorbed hydrophilic VOCs (e.g., acetone) from aqueous absorbents has become one of the major challenges in practical applications. Hydrophobic deep eutectic solvents (DESs) have therefore been developed as novel green absorbents for capturing hydrophilic VOCs in the present work. The compiled results show that efficient hydrophilic VOC elimination can be accomplished by the proposed hydrophobic DESs through high absorption capacity and thermodynamically favorable gas-to-liquid mass transfer. Among the explored DESs, the hydrophobic DES containing thymol [Thy] and decanoic acid [DecA] with a molar ratio of 1:1 has achieved the highest absorption capacity of acetone, i.e., 6.57 mg acetone per g DES at 20 °C and 1480 ppm acetone. The oxygen of acetone interacts favorably with the hydrogen atom of [Thy] upon absorption, rendering hydrogen bonding interaction surpassing polarity as the key factor in attaining superior solubility of acetone in DESs. Moreover, the absorbed acetone can be easily removed from Thy-based DESs, realizing an effective hydrophilic VOC elimination process with economic and ecological benefits.