Advancements in Bio-inspired Self-Powered Wireless Sensors: Materials, Mechanisms, and Biomedical Applications.

The rapid maturation of smart city ecosystems is intimately linked to advances in the Internet of Things (IoT) and self-powered sensing technologies. Central to this evolution are battery-less sensors that are critical for applications such as continuous health monitoring through blood metabolites and vital signs, the recognition of human activity for behavioral analysis, and the operational enhancement of humanoid robots. The focus on biosensors that exploit the human body for energy-spanning wearable, attachable, and implantable variants has intensified, driven by their broad applicability in areas from underwater exploration to biomedical assays and earthquake monitoring. The heart of these sensors lies in their diverse energy harvesting mechanisms, including biofuel cells, and piezoelectric, triboelectric, and pyroelectric nanogenerators. Notwithstanding the wealth of research, the literature still lacks a holistic review that integrates the design challenges and implementation intricacies of such sensors. Our review seeks to fill this gap by thoroughly evaluating energy harvesting strategies from both material and structural perspectives and assessing their roles in powering an array of sensors for myriad uses. This exploration offers a comprehensive outlook on the state of self-powered sensing devices, tackling the nuances of their deployment and highlighting their potential to revolutionize data gathering in autonomous systems. The intent of this review is to chart the current landscape and future prospects, providing a pivotal reference point for ongoing research and innovation in self-powered wireless sensing technologies.

AuNP-based biosensors for the diagnosis of pathogenic human coronaviruses: COVID-19 pandemic developments.

The outbreak rate of human coronaviruses (CoVs) especially highly pathogenic CoVs is increasing alarmingly. Early detection of these viruses allows treatment interventions to be provided more quickly to people at higher risk, as well as helping to identify asymptomatic carriers and isolate them as quickly as possible, thus preventing the disease transmission chain. The current diagnostic methods such as RT-PCR are not ideal due to high cost, low accuracy, low speed, and probability of false results. Therefore, a reliable and accurate method for the detection of CoVs in biofluids can become a front-line tool in order to deal with the spread of these deadly viruses. Currently, the nanomaterial-based sensing devices for detection of human coronaviruses from laboratory diagnosis to point-of-care (PoC) diagnosis are progressing rapidly. Gold nanoparticles (AuNPs) have revolutionized the field of biosensors because of the outstanding optical and electrochemical properties. In this review paper, a detailed overview of AuNP-based biosensing strategies with the varied transducers (electrochemical, optical, etc.) and also different biomarkers (protein antigens and nucleic acids) was presented for the detection of human coronaviruses including SARS-CoV-2, SARS-CoV-1, and MERS-CoV and lowly pathogenic CoVs. The present review highlights the newest trends in the SARS-CoV-2 nanobiosensors from the beginning of the COVID-19 epidemic until 2022. We hope that the presented examples in this review paper convince readers that AuNPs are a suitable platform for the designing of biosensors.

A critical review on quantum dots: From synthesis toward applications in electrochemical biosensors for determination of disease-related biomolecules.

Fluorescent quantum dots (QDs), defined by a diameter size of <10 nm, have been the core concept of nanoscience and nanotechnology since their inception. QDs possess many unique structural, electrochemical and photochemical properties that render them a promising platform for sensing applications. These nanomaterials can greatly enhance the analytical performances of biosensors, namely detection limit, sensitivity and selectivity. QDs are being developed not only because of their ability for signal enhancement but also because of their high capacity for fuctionalization with bioreceptors. In this review, we summarize a basic knowledge of QDs before focusing on their application to sensing thus far followed by a discussion of future directions for research into the sensing field. Due to the nature of QDs, especially their ability to combine nanotechnology and biotechnology, they possess the potential to open a novel paradigm on early diagnosis of diseases using the electrochemical biosensors. Therefore, we try to give a comprehensive view of the role of these zero-dimensional (0D) nanomaterials in the designing electrochemical sensors for determination of disease-related biomolecules, including tumor markers, inflammatory biomarkers, depression markers and archetypal biomarker in diabetes diagnosis. Considering the high potential of QDs for the electrochemistry-based biosensing strategies, the authors suggest that more research is needed on understanding their electronic properties and why synthesis and surface modification methods can affect these properties.