Hypoglycemia and hyperglycemia in neonatal encephalopathy: A narrative review.

Neonatal encephalopathy (NE) is a serious condition with various neurological dysfunctions in newborns. Disruptions in glucose metabolism, including both hypoglycemia and hyperglycemia, are common in NE and can significantly impact outcomes. Hypoglycemia, defined as blood glucose below 45 mg/dL, is associated with increased mortality, neurodevelopmental disabilities, and brain lesions on MRI. Conversely, hyperglycemia, above 120 to 150 mg/dL, has also been linked to heightened mortality, hearing impairment, and multiorgan dysfunction. Both aberrant glucose states appear to worsen prognosis compared to normoglycemic infants. Therapeutic hypothermia is the standard of care for NE that provides neuroprotection by reducing metabolic demands and inflammation. Adjunct therapies like glucagon and continuous glucose monitoring show promise in managing dysglycemia and improving outcomes. Glucagon can enhance cerebral blood flow and glucose supply, while continuous glucose monitoring enables real-time monitoring and personalized interventions. Maintaining balanced blood sugar levels is critical in managing NE. Early detection and intervention of dysglycemia are crucial to improve outcomes in neonates with encephalopathy. Further research is needed to optimize glycemic management strategies and explore the potential benefits of interventions like glucagon therapy.

Unkinking The Kinked: A Rare Intussusception In The Paediatric Emergency Department.

Intussusception is the introversion of the proximal intestinal loop into the distal downstream part of the intestinal loop, leading to gut wall oedema and restriction of blood supply. A high index of suspicion is required to diagnose it timely. Mostly infants aged less than a year are vulnerable to this surgical emergency presenting mostly with abdominal distension, vomiting, reluctance to feed and bright red jelly-like stools which, if left unrecognised, may result in the development of ischaemic portion of the gut and catastrophic outcomes. We present the case of a 60-day-old baby who presented in the Paediatric Emergency Department with progressive abdominal distension and bloody stools. Abdominal X-ray showed dilated bowel and ultrasound imaging showed a target sign positive for intussusception. The baby was rushed to the operating room (OR) due to delayed presentation, where an uneventful exploratory laparotomy was performed. Acute intestinal intussusception remains a cause of low morbidity and mortality rates if recognised earlier.

Assessment of Medical Professionalism: Development and psychometric analysis of Professionalism Assessment Tool (PAT) in Pakistani context using Delphi Techniques.

Objective: This study aims to develop and assess the content validity along with the reliability of a Professionalism Assessment Tool (PAT) with an intention to measure professionalism among undergraduate medical students. Methods: This psychometric analytical study validation study was carried out at Rawalpindi Medical University from 1st February to 1st June, 2021 after establishing feasibility and obtaining ethical approval. The non-probability convince sampling was employed to collect data. Using Nunnally's, the ratio of e subjects per item was selected, as our preliminary tool has 48 items so 384 sample size was estimated for scale validation. The preliminary 48-item tool with five subscales(cSS) developed through mutual consensus by the Delphi technique namely Communication skill(cSS1),-7 item, Accountability(cSS2)-8 item, Altruism(cSS3)-13 item, Self-Directed Learning (cSS4)-10 item and Ethics(cSS5),-10 item was labelled as Professionalism Assessment Tool (PAT). The tool was administered to 4th year MBBS students, the data obtained was analyzed by calculating Cronbach's alpha to estimate the reliability. The SPSS version 26 was used for data analysis. Results: The 48-item PAT had an overall reliability (Cronbach's alpha) of 0.783. The Reliability of the new Subscales were communication skills (0.405), self-directed learning (0.527), Accountability (0.378), Altruism (0.486) and Ethics (0.715). Conclusion: The final tool developed for assessment of professionalism had 48 items on a seven point Likert like scale, across five Subscales. Results showed that it was determined as a useful tool in assessing professionalism in undergraduate medical students to generate reliable results for valid decision-making.

Fetal outcome of cases with diaphragmatic hernia.

OBJECTIVE: The aim of this study is to report the short-term morbidity of congenital diaphragmatic hernia at a tertiary referral center in Karachi, Pakistan. METHODS: It is a retrospective cohort study of fetuses with congenital diaphragmatic hernia from January 2001 to December 2011. This includes all cases with prenatal diagnosis and those presenting in the postnatal period. This study analyses the survival of these cases and assesses the prognostic factors associated with the mortality of this condition. RESULTS: During the 11 year study period, 65 cases of diaphragmatic hernia were identified. Among these, 41 cases were diagnosed in the antenatal period while the rest of the 24 presented in the postnatal period. Fifty-eight out of the 65 (89%) were born alive. Only 38% of these survived beyond 28 days of life. Factors like antenatal diagnosis and birthweight significantly influenced the outcome while mode of delivery, site of lesion and gestational age at delivery did not affect the prognosis. CONCLUSION: The overall mortality of congenital diaphragmatic hernia remains high. Survival rate of isolated hernia was substantially higher than those who had associated anomalies. The data from this study will provide the basis for counseling women in our setup.