1.
Bull Exp Biol Med
; 137(3): 242-5, 2004 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15232629
RESUMO
In women with various gynecological disorders, ATP, ADP, and 2-methylthio-ATP dose-dependently potentiated spontaneous contractility of isolated fallopian tubes, while alpha,beta-methylene-ATP and uridine triphosphate were little efficient. Pyridoxal phosphate-6-azophenyl-2',4'-disulphonic acid, a P2-receptor antagonist, inhibited responses to 2-methylthio-ATP, produced no effect on responses to ATP, and potentiated ADP-induced responses in fallopian tubes. During inflammation, sensitivity of fallopian tubes to P2 agonists and antagonists decreased. The data attest to the presence of functionally active P2 receptors in human fallopian tubes probably involved in the regulation of their mechanical activity.
Assuntos
Trifosfato de Adenosina/análogos & derivados , Tubas Uterinas/efeitos dos fármacos , Tubas Uterinas/fisiologia , Agonistas do Receptor Purinérgico P2 , Antagonistas do Receptor Purinérgico P2 , Difosfato de Adenosina/farmacologia , Trifosfato de Adenosina/farmacologia , Adulto , Feminino , Humanos , Técnicas In Vitro , Pessoa de Meia-Idade , Receptores Purinérgicos P2/fisiologia , Salpingite/fisiopatologia , Tionucleotídeos/farmacologia
2.
Akush Ginekol (Mosk)
; (1): 17-8, 1982 Jan.
Artigo
em Russo
| MEDLINE
| ID: mdl-7065363