[The effectiveness of the spa and health resort-based treatment with the application of Essentuki-type drinking mineral waters for the management of non-alcoholic fatty liver disease in the patients presenting with type 2 diabetes mellitus].

The objective of the present study was to estimate the effectiveness of the spa and health resort-based treatment of non-alcoholic fatty liver disease in 40 patients at the mean age of 48,8 ± 5.7 years suffering from type 2 diabetes mellitus. All of them received combined therapy including the application of potable Essentuki-Novaya mineral water (20 patients) or Essentuki No 4 water (20 patients). This therapeutic modality resulted in positive dynamics of clinical symptoms of the disease, the functional liver tests, and parameters of intra-hepatic hemodynamics, lipid peroxidation homeostasis, and the hormonal status. It is concluded that the spa and health resort-based treatment with the application of local drinking Essentuki-type mineral waters for the management of non-alcoholic fatty liver disease in the patients presenting with type 2 diabetes mellitus leads to the improvement of the main functions of the liver, stabilizes carbohydrate and lipid metabolism, and prevents progression of the pathological process.

[The use of mineral waters for the rehabilitative treatment of the patients with non-alcoholic lesions of the liver in the hospital environment].

A method has been developed for the correction of metabolic, hepato-biliary, and ischemic disorders in the patients with chronic nonalcoholic lesions of the liver by means of combined treatment using pharmaceutical agents (ursosan and Omega-3), Tib-2 drinking mineral water, and sinusoidal modulated currents (SMC) electrophoresis of this water in the right hypochondrial region. This therapy ensured pathogenetically sound modulation of the functional state of the liver and the biliary tract; moreover, it reduced the severity of regional ischemia, improved rheologic properties of the blood, normalized lipid metabolism and peroxidation, influenced production ofpro-inflammatory cytokines.

[Balneotherapeutics of non-alcoholic fatty liver disease with the use of the Essentuki-type drinking mineral waters].

The objective of the present work was to estimate the effectiveness of combined spa-and-resort treatment with the use of the Essentuki-type drinking mineral waters for the patients presenting with non-alcoholic fatty liver disease. A total of 40 patients presening with non-alcoholic fatty liver disease (NOFLD) were available for the examination. The study has demonstrated positive dynamics of clinical symptoms and results of liver functional tests, characteristics of intrahepatic dynamics, lipid metabolism, antioxidant hemostais, and the hormonal status of the patients with non-alcoholic fatty liver disease. The intake of the Essentuki-type drinking mineral waters promoted normalization of adiponectin and leptin levels in conjunction with the reduction in the degree of insulin resistance, i.e., the key pathogenetic factors responsible for hepatic steatosis and non-alcoholic steatohepatitis. It is concluded that the Essentuki-type drinking mineral waters may be recommended for the inclusion in the combined treatment and prevention of the progression of non-alcoholic fatty liver disease.

[The dynamics of leukocyte adhesion to the endothelium pial venules under massive blood loss]. / Osobennosti dinamiki adgezii leikotsitov k éndoteliiu pial'nykh venul pri massivnoi krovopotere.

The dynamics of leukocytes adhesion to brain microvenules endothelium of Wistar rats were studied under acute massive blood loss. Using the method of vital videomicroscope study of the influence of the influence of the blood volume reduction on the leukocyte-endothelium interaction is investigated. We studied vessels of the diameter under 30 mcm. It is shown that under progressing reduction of the system arterial pressure under 60 mm Hg, the number of leukocytes adhesion to venules' wall reached 20 +/- 3 on 100 mcm, but in terminal stage such acts are the greatest. It is supposed that as a result massive blood loss leukocytes turn out to be the direct reason of the deep pathological disturbances of microcirculation in the brain.

[Recovery of the gas exchange and oxygen transport after long-term hypothermia in rats]. / Vosstanovlenie gazoobmena i transporta kisloroda u krys posle prolongirovannoi gipotermii.

After a deep prolonged hypothermia, fast warming up of experimental rats (0.26 degree C/min) to the body temperature 35-36 degrees C entailed recovery of the heart rate, blood pressure, 1-min blood volume, oxygen consumption in rats. However, in the process of warming up, cardiac output, function of the left ventricle, oxygen consumption and the CO2 production were decreased. Acidosis and haemoconcentration following a 3 hr prolonged hypothermia were reversible.

[Recovery of the oxygen consumption, oxygen transport, and cardiac activity after hypothermia followed by respiration and cardiac arrest in rats]. / Vosstanovlenie potrebleniia kisloroda, transporta kisloroda i serdechnoi deiatel'nosti u krys posle gipotermii, soprovozhdaiushcheisia ostanovkoi dykhaniia i serdechnykh sokrashchenii.

After a 1 hr deep prolonged immersion hypothermia, warming up of experimental rats in water (the temperature increase 0.25 degree C/min) entailed a complete recovery of all the parameters of gas exchange, haemodynamics, external respiration, and the blood. After a 3 hr hypothermia, under the same conditions of warming up, oxygen consumption, CO2 production, and 1 min blood volume were obviously decreased, and the animals died within 0.5-1.0 hr.

[Gas exchange and oxygen transport during long term hypothermia following a hypothermal apnea in rats]. / Gazoobmen i transport kisloroda u krys v usloviiakh prolongirovannoí gipotermii posle gipotermicheskoi ostanovki dykhaniia.

The data obtained show that, at the initial stages of hypothermia, a decrease in the oxygen consumption and carbon dioxide production, cardiac output, and heart rate occurred in accordance with the temperature coefficient. Suppression of the tissue gas exchange was unrelated to disorders in the lung gas exchange but determined rather by a progressing weakening of heart activity, decrease in the cardiac output, and increase in the general vascular peripheral resistance.

[Gas exchange and gas transport in deeply cooled rats during slow and rapid warming using artificial pulmonary ventilation]. / Gazoobmen i transport gazov u gluboko okhlazhdennykh krys v protsesse medlennogo i bystrogo otogrevaniia s primeneniem iskusstvennoi ventiliatsii legkikh.

Artificial lung ventilation (ALV) was shown to restore the gas exchange in rats following their cooling to brain temperature 17.0-17.6 degrees C. However, the ALV proved ineffective if applied in 22.1 +/- 2.1 min after cessation of breathing. Fast warming up of the animals increased oxygen consumption and carbon dioxide production, and caused a less obvious metabolic acidosis in the rats in the course of recovering from hypothermia.

[Gas exchange and gas transport in rats during warming after deep immersion hypothermia]. / Gazoobmen i transport gazov u krys v protsesse otogrevaniia posle glubokoi immersionnoi gipotermii.

Gas exchange, oxygen transport and utilisation were shown to be limited at body temperature 17.5 degrees C in rats. Disturbances in the cardio-vascular system seem to be the main limiting factors telling on the above parameters in the course of spontaneous rewarming.

[Oxygen transport and gas exchange in rats under immersion hypothermia]. / Transport kisloroda i gazoobmen u krys v usloviiakh immersionnoi gipotermii.

Changes of the oxygen consumption and the main parameters of the blood respiratory function as well as oxygen transport, were studied in Wistar rats under conditions of immersion hypothermia (with rectal temperature 15-13 degrees C). From the viewpoint of the oxygen exchange, the rectal temperature 20 degrees C was found to be the critical level of the hypothermia.