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1.
J Pediatr Orthop ; 2024 Oct 09.
Artigo em Inglês | MEDLINE | ID: mdl-39380182

RESUMO

BACKGROUND: Arthrogryposis multiplex congenita (AMC) encompasses congenital conditions with joint contractures in 2 or more joints. Patients with AMC may have scoliosis and neural axis malformations. The study aimed to determine the prevalence of tethered spinal cord (TSC), characterized by a low-lying conus medullaris, and secondarily, present preliminary findings following surgical untethering in children with AMC. METHODS: Patients 18 years of age and younger with a diagnosis of AMC and a spine MRI were identified. The presence of a TSC was defined as a low-lying conus with termination at or below the lower third of the L2 vertebral body. A pediatric neurosurgeon and a pediatric orthopaedic surgeon independently reviewed MRIs. The medical records of patients with AMC who underwent untethering were examined to evaluate preoperative and postoperative clinical findings. The prevalence of TSC in our AMC patients was compared with published normative data using χ2 analysis. RESULTS: Forty-two of 105 AMC patients (40%) had TSCs. There was a greater percentage of patients with AMC and a TSC compared with the unaffected population (P<0.0001). Sixteen patients underwent detethering through filum terminale sectioning. Nine patients had preoperative neurological deficits in addition to their AMC. There were no postoperative complications. All patients had improvement in their bowel and bladder symptoms within 3 months after their detethering procedure. CONCLUSIONS: TSC is more prevalent in the pediatric population with AMC compared with those without AMC. MRI is recommended for all patients with AMC due to its high prevalence. Although not a benign procedure, surgical detethering may have potential benefits for children with AMC. LEVEL OF EVIDENCE: Level IV-therapeutic study.

2.
J Pediatr Orthop ; 2024 Oct 17.
Artigo em Inglês | MEDLINE | ID: mdl-39466235

RESUMO

BACKGROUND: Surgery for knee flexion contractures in patients with arthrogryposis multiplex congenital (AMC) have achieved extension to redirect the arc of motion and improve ambulation but has not demonstrated maintained increases in total range of motion (ROM). This study aimed to review the clinical outcomes of combined posterior knee release, proximal femoral shortening, and nerve decompression in patients with arthrogryposis. METHODS: A retrospective chart and radiographic review were performed on patients with AMC who underwent treatment for knee flexion deformities ≥30 degrees. ROM, ambulation status, and orthotic use were reviewed and analyzed. Complications were recorded. RESULTS: Twenty-nine patients with 51 knees and a mean age of 5.7 years were included. The mean follow-up was 36.9 months. The mean ROM increased from 49 to 80 degrees between pre-op and latest follow-up (P<0.0001). The mean final follow-up flexion deformity was 10 degrees (P<0.0001). Preoperative ROM was moderately correlated with final ROM (rs=0.51). The percentage of ambulatory patients improved from 39% to 93%. Five limbs experienced a fracture either intraoperatively or postoperatively, and 5 limbs required a return trip to the operating room. CONCLUSIONS: Improved ambulation and knee ROM can be maintained in patients with AMC at a minimum 2-year follow-up. Prospective investigation and longer follow-up are required to validate these findings. LEVEL OF EVIDENCE: Level IV-therapeutic.

3.
J Bone Joint Surg Am ; 106(14): 1277-1285, 2024 Jul 17.
Artigo em Inglês | MEDLINE | ID: mdl-38662808

RESUMO

BACKGROUND: To our knowledge, there have been no studies examining peroneal nerve decompression and proximal fibular osteochondroma excision exclusively in patients with multiple hereditary exostoses (MHE). The purpose of this study was to evaluate the indications, complications, and recurrence associated with nerve decompression and proximal fibular osteochondroma excision in patients with MHE. METHODS: The records on patients with MHE undergoing peroneal nerve decompression from 2009 to 2023 were retrospectively reviewed. Indications, clinical status, surgical technique, recurrence, and complications were recorded and were analyzed using the Fisher exact test, logistic regression, and the Kaplan-Meier method. RESULTS: There were 126 limbs identified in patients with MHE who underwent peroneal nerve decompression. The most common indications were pain over the proximal fibula, tibialis anterior and/or extensor hallucis longus weakness, and dysesthesias and/or neuropathic pain. Seven cases experienced postoperative foot drop as a complication of the decompression and osteochondroma excision. Logistic regression found significant relationships between complications and excision of anterior osteochondromas (odds ratio [OR], 5.21; p = 0.0062), proximal fibular excision (OR, 14.73; p = 0.0051), and previous decompression (OR, 5.77; p = 0.0124). The recurrence rate was 13.8%, and all recurrences occurred in patients who were skeletally immature at the index procedure. The probability of skeletally immature patients not experiencing recurrence was 88% at 3 years postoperatively and 73% at 6 years postoperatively. CONCLUSIONS: Indications for peroneal nerve decompression included neurologic symptoms and pain. The odds of a complication increased with excision of anterior osteochondromas and previous decompression. Recurrence of symptoms following decompression and osteochondroma excision was found exclusively in skeletally immature patients. LEVEL OF EVIDENCE: Therapeutic Level III . See Instructions for Authors for a complete description of levels of evidence.


Assuntos
Descompressão Cirúrgica , Exostose Múltipla Hereditária , Nervo Fibular , Humanos , Descompressão Cirúrgica/métodos , Descompressão Cirúrgica/efeitos adversos , Exostose Múltipla Hereditária/cirurgia , Exostose Múltipla Hereditária/complicações , Masculino , Feminino , Nervo Fibular/cirurgia , Estudos Retrospectivos , Adolescente , Criança , Adulto , Adulto Jovem , Fíbula/cirurgia , Complicações Pós-Operatórias/etiologia , Pessoa de Meia-Idade , Neoplasias Ósseas/cirurgia , Resultado do Tratamento , Neuropatias Fibulares/cirurgia , Neuropatias Fibulares/etiologia , Recidiva Local de Neoplasia/cirurgia
4.
J Pediatr Orthop ; 44(7): 448-455, 2024 Aug 01.
Artigo em Inglês | MEDLINE | ID: mdl-38595075

RESUMO

BACKGROUND: Individuals with achondroplasia are prone to symptomatic spinal stenosis requiring surgery. Revision rates are thought to be high; however, the precise causes and rates of reoperation are unknown. The primary aim of this study is to investigate the causes of reoperation after initial surgical intervention in individuals with achondroplasia and spinal stenosis. In addition, we report on surgical techniques aimed at reducing the risks of these reoperations. METHODS: A retrospective review was conducted over an 8-year period of all patients with achondroplasia at a single institution that serves as a large referral center for patients with skeletal dysplasias. Patients with achondroplasia who underwent spinal surgery for stenosis were identified and the need for revision surgery was studied. Data collected included demographic, surgical, and revision details. Fisher exact test was used to determine if an association existed between construct type and the need for revisions. RESULTS: Thirty-three of the 130 (22%) patients with achondroplasia required spinal stenosis surgery. Twenty-four individuals who met the criteria were selected for analysis. The initial spine surgery was at an average age of 18.7 years (SD: 10.1 y). Nine patients (38%) required revision surgeries, and 3 required multiple revisions. Five of 9 (56%) of the revisions had primary surgery at an outside institution. Revision surgeries were due to caudal pseudarthrosis (the distal instrumented segment) (8), proximal junctional kyphosis (PJK) (7), and new neurological symptoms (7). There was a significant association found between construct type and the need for revision ( P =0.0111). The pairwise comparison found that short fusions were significantly associated with the need for revision compared with the interbody group ( P =0.0180). PJK was associated with short fusions when compared with the long fusion group ( P =0.0294) and the interbody group ( P =0.0300). Caudal pseudarthrosis was associated with short fusions when compared with the interbody group ( P =0.0015). Multivariate logistic regression found long fusion with an interbody was predictive of and protective against the need for revision surgery ( P =0.0246). To date, none of the initial cases that had long fusions with caudal interbody required a revision for distal pseudarthrosis. CONCLUSIONS: In patients with achondroplasia, the rate of surgery for spinal stenosis is 22% and the risk of revision is 38% and is primarily due to pseudarthrosis, PJK, and recurrent neurological symptoms. Surgeons should consider discussing spinal surgery as part of the patient's life plan and should consider wide decompression of the stenotic levels and long fusion with the use of an interbody cage at the caudal level in all patients to reduce risks of revision. LEVEL OF EVIDENCE: Level IV-Retrospective case series.


Assuntos
Acondroplasia , Reoperação , Estenose Espinal , Humanos , Acondroplasia/cirurgia , Acondroplasia/complicações , Reoperação/estatística & dados numéricos , Estudos Retrospectivos , Estenose Espinal/cirurgia , Estenose Espinal/etiologia , Masculino , Feminino , Adolescente , Criança , Adulto Jovem , Adulto , Fatores de Risco , Complicações Pós-Operatórias/etiologia , Fusão Vertebral/métodos , Fusão Vertebral/efeitos adversos , Pseudoartrose/cirurgia , Pseudoartrose/etiologia
5.
Cardiol Young ; 32(2): 230-235, 2022 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-33966676

RESUMO

Patients with single-ventricle CHD undergo a series of palliative surgeries that culminate in the Fontan procedure. While the Fontan procedure allows most patients to survive to adulthood, the Fontan circulation can eventually lead to multiple cardiac complications and multi-organ dysfunction. Care for adolescents and adults with a Fontan circulation has begun to transition from a primarily cardiac-focused model to care models, which are designed to monitor multiple organ systems, and using clues from this screening, identify patients who are at risk for adverse outcomes. The complexity of care required for these patients led our centre to develop a multidisciplinary Fontan Management Programme with the primary goals of earlier detection and treatment of complications through the development of a cohesive network of diverse medical subspecialists with Fontan expertise.


Assuntos
Técnica de Fontan , Cardiopatias Congênitas , Coração Univentricular , Adolescente , Adulto , Técnica de Fontan/efeitos adversos , Cardiopatias Congênitas/cirurgia , Humanos , Cuidados Paliativos
6.
J Pediatric Infect Dis Soc ; 10(8): 801-844, 2021 Sep 23.
Artigo em Inglês | MEDLINE | ID: mdl-34350458

RESUMO

This clinical practice guideline for the diagnosis and treatment of acute hematogenous osteomyelitis (AHO) in children was developed by a multidisciplinary panel representing Pediatric Infectious Diseases Society (PIDS) and the Infectious Diseases Society of America (IDSA). This guideline is intended for use by healthcare professionals who care for children with AHO, including specialists in pediatric infectious diseases, orthopedics, emergency care physicians, hospitalists, and any clinicians and healthcare providers caring for these patients. The panel's recommendations for the diagnosis and treatment of AHO are based upon evidence derived from topic-specific systematic literature reviews. Summarized below are the recommendations for the diagnosis and treatment of AHO in children. The panel followed a systematic process used in the development of other IDSA and PIDS clinical practice guidelines, which included a standardized methodology for rating the certainty of the evidence and strength of recommendation using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) approach. A detailed description of background, methods, evidence summary and rationale that support each recommendation, and knowledge gaps can be found online in the full text.


Assuntos
Doenças Transmissíveis , Osteomielite , Pediatria , Doença Aguda , Criança , Doenças Transmissíveis/diagnóstico , Doenças Transmissíveis/terapia , Humanos , Infectologia , Osteomielite/diagnóstico , Osteomielite/terapia
7.
J Bone Joint Surg Am ; 2021 Aug 25.
Artigo em Inglês | MEDLINE | ID: mdl-34432742

RESUMO

BACKGROUND: Multiple hereditary exostoses (MHE) is a rare bone disease that results in growth of benign cartilage-capped tumors and a number of skeletal deformities. Forearm deformities are present in up to 60% of patients with MHE, and radial head subluxation or dislocation occurs in 20% to 30%. Radial head subluxation/dislocation results in a shortened forearm and loss of motion. The purpose of this study was to identify radiographic variables that are most predictive of radial head subluxation/dislocation in an effort to determine the need for prophylactic treatment. METHODS: We retrospectively reviewed the cases of consecutive patients with MHE treated in our center between April 2007 and December 2019. Radiographic measurements included the presence or absence of distal ulnar osteochondromas, total ulnar bow, total radial bow, and percent ulnar length. Participants were separated into 3 groups based on the status of the radial head: located, subluxated, and dislocated. Radiographic measurements were compared using a Kruskal-Wallis H test with Dunn post-hoc analysis. A prediction model was run using a binomial logistic regression, and a prediction matrix was created. RESULTS: A total of 88 patients were included in the study. There were significant differences in the located group compared with the dislocated group in terms of pronation, supination, and extension. The percent ulnar length, total ulnar bow, and total radial bow differed significantly between the located and dislocated groups (p < 0.0001); however, in the binomial regression analysis, only the percent ulnar length and total ulnar bow could be used to distinguish between the located group and the subluxated/dislocated group. Both of these measurements were significant predictors of subluxation/dislocation. There was no radial head subluxation/dislocation in patients with an ulnar bow of <17°. CONCLUSIONS: The data indicate that total ulnar bow and percent ulnar length are good predictors of radial head subluxation/dislocation. These 2 parameters can be utilized to monitor forearm deformity and guide timing for prophylactic treatment. LEVEL OF EVIDENCE: Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.

8.
Children (Basel) ; 8(7)2021 Jun 24.
Artigo em Inglês | MEDLINE | ID: mdl-34202890

RESUMO

Arthrogryposis multiplex congenita (AMC) is a rare condition defined as contrac-tures in multiple joints. Surgical interventions for severe knee flexion contractures have included posterior release, distraction and extension with external fixation and distal femoral extension osteotomies. These operations have been able to achieve knee extension, but not increase the range of motion. The purpose of this study was to review our experience with peroneal nerve decompression, posterior knee release and proximal femoral shortening. We retrospectively reviewed the medical charts and radiographs of all patients with a diagnosis of arthrogryposis who underwent aforementioned procedure. There were 39 patients with 73 knees included in the analysis with a mean follow-up of 21 months. The mean preoperative arc of motion was 45° and last followup arc of motion was 79° (p < 0.0001). The mean last followup flexion contracture was 8° (p < 0.0001). Additional subanalyses were performed on those with followup greater than 24 months and those with flexion contractures >60°; there were no differences found in these groups. This study demonstrates that it is possible to achieve a functional range of motion of the knees in patients with AMC while improving ambulatory function.

9.
Children (Basel) ; 8(6)2021 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-34198529

RESUMO

There are multiple forms of enchondromatosis with Ollier's and Maffucci's being the most prevalent types. Limb length discrepancy is a common problem in patients with Ollier's and Maffucci's enchondromatosis. There are multiple reports about lengthening bones in patients with enchondromatosis using external fixators. However, there are no case series regarding the use of implantable lengthening technology. The purpose of this paper is to describe our experience with implantable nail lengthening in patients with enchondromatosis. A retrospective chart and radiographic review of patients with enchondromatosis who underwent implantable nail limb lengthening was performed. Seven patients with 14 bony segments were reviewed. A total of 11/14 lengthenings were completed without difficulty. There were no issues in terms of fixation location in patients with Ollier's disease. One patient with Maffucci's syndrome experienced migration of the nail during two lengthenings due to a combination of intralesional fixation and preconsolidation. One patient with Ollier's disease developed a knee extension contracture requiring manipulation under anesthesia. No other complications were recorded. The use of implantable nail lengthening to resolve limb length discrepancies in patients with Ollier's disease appears to be safe and effective.

10.
J Pediatr Orthop ; 41(2): e111-e115, 2021 Feb 01.
Artigo em Inglês | MEDLINE | ID: mdl-33165261

RESUMO

BACKGROUND: Congenital femoral deficiency (CFD) is a rare condition that affects the morphology of the hip and surrounding soft tissues. Bony deformity and distorted muscular anatomy are well known, but no studies have described the relationship of the femoral neurovascular (NV) bundle to surgically relevant anatomic landmarks. The authors compared the location of the femoral NV bundle on the affected side in patients with CFD with the unaffected side. The authors hypothesized that the bundle on the pathologic side would be in an abnormal position relative to the unaffected side. METHODS: Thirty-three patients diagnosed with unilateral CFD who had undergone preoperative magnetic resonance imaging of the pelvis were included in our study. The authors identified the femoral NV bundle on the axial cuts and measured its distance from the anterior superior iliac spine (ASIS), anterior inferior iliac spine (AIIS), and lesser trochanter (LT). Anatomic percent change and absolute measurements were then compared and correlated with associated boney deformities and the Paley classification. RESULTS: The distance from the femoral NV bundle to the ASIS, AIIS, and LT was significantly different compared with the unaffected side. The AIIS absolute distance and AIIS percent change significantly correlated with the neck-shaft angle of the proximal femur. CONCLUSIONS: In patients with CFD, the femoral NV bundle seems to be further from the LT and closer to the AIIS on the affected side when compared with the unaffected side. magnetic resonance imaging may be helpful to understand the course of the femoral NV bundle before reconstruction in patients with CFD; however, the authors recommend identification of the femoral NV bundle before transection of the proximal rectus femoris tendon to provide safe surgical care. LEVEL OF EVIDENCE: Level IV-case-control study of diagnostic studies.


Assuntos
Artéria Femoral/diagnóstico por imagem , Nervo Femoral/diagnóstico por imagem , Veia Femoral/diagnóstico por imagem , Fêmur/anormalidades , Articulação do Quadril/anormalidades , Pontos de Referência Anatômicos , Estudos de Casos e Controles , Criança , Pré-Escolar , Feminino , Fêmur/irrigação sanguínea , Fêmur/diagnóstico por imagem , Fêmur/inervação , Articulação do Quadril/irrigação sanguínea , Articulação do Quadril/diagnóstico por imagem , Articulação do Quadril/inervação , Humanos , Ílio/diagnóstico por imagem , Lactente , Masculino , Pelve/diagnóstico por imagem , Músculo Quadríceps/cirurgia , Estudos Retrospectivos , Tendões/cirurgia
11.
Bull Hosp Jt Dis (2013) ; 77(4): 250-255, 2019 12.
Artigo em Inglês | MEDLINE | ID: mdl-31785138

RESUMO

BACKGROUND: Supracondylar humerus fractures account for two thirds of all hospitalizations for elbow injuries in children. A prevailing assumption exists regarding whether treatment quality varies by surgeon training background. This study compares radiographic outcomes of pediatric supracondylar humerus fractures treated by fellowship trained pediatric orthopedists (PO) and non-pediatric orthopedists (adult traumatologists, AT) with regard specifically to ability to obtain and maintain an operative closed reduction. METHODS: We retrospectively reviewed all pediatric patients between 2007 and 2013 operatively treated for closed extension-type supracondylar humerus fractures. Inclusion criteria included skeletally immature patients with Gartland classification type II and III fractures. Eighty-five cases were included with 37 fractures treated by four fellowship trained adult traumatologists at a level I trauma center and 48 fractures treated by five fellowship trained pediatric orthopedists at a tertiary referral center. Radiographs were analyzed for Baumann's angle and shaft-condylar angle, then statistical comparisons were performed to compare preoperative and postoperative measurements. RESULTS: There was no difference in age, gender, laterality, fracture classification, use of medial pins, or neurovascular injuries between PO and AT (p > 0.05). Change in Baumann's angle (p = 0.61) or shaft-condylar angle (p = 0.87) did not differ between PO and AT. There was no significant difference in operative and postoperative Baumann's angle (p = 0.18 and p = 0.59, respectively) and shaft-condylar angle measurements (p = 0.05 and p = 0.09, respectively) between PO and AT. There was no difference in loss of reduction between the two groups (p = 0.64). CONCLUSIONS: Radiographic analysis of supracondylar humerus fractures showed no significant difference in alignment or loss of reduction when treated by pediatric orthopedists compared to non-pediatric orthopedists. Though it seems that the trend is to send pediatric fracture care to tertiary referral centers it may not be necessary for simple fracture management.


Assuntos
Redução Fechada/educação , Educação de Pós-Graduação em Medicina , Fraturas do Úmero/cirurgia , Cirurgiões Ortopédicos/educação , Pediatras/educação , Pediatria/educação , Pinos Ortopédicos , Criança , Pré-Escolar , Competência Clínica , Redução Fechada/efeitos adversos , Redução Fechada/instrumentação , Currículo , Feminino , Consolidação da Fratura , Humanos , Fraturas do Úmero/diagnóstico por imagem , Fraturas do Úmero/fisiopatologia , Lactente , Masculino , Estudos Retrospectivos , Resultado do Tratamento
12.
Bull Hosp Jt Dis (2013) ; 77(3): 172-182, 2019 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-31487482

RESUMO

BACKGROUND: Bracing (thoraco-lumbar-sacral orthosis) has been accepted as mainstay of treatment for symptomatic spondylolysis (SP) and grade I spondylolisthesis (SPL1). However, increasing costs and patient noncompliance can make bracing prohibitive and difficult to manage. The purpose of this study was to determine if SP and SPL1 can be effectively treated using physical therapy and other non-bracing conservative management techniques in order to relieve pain and restore physical function. METHODS: We performed a cross-sectional study in which patients who presented from June 1, 2004, to May 1, 2015, with symptomatic SP and SPL1 who were treated with nonbracing conservative management, entailing a universal 6-week physical therapy program and restriction of offending activity, were considered for the study. Physical therapy included core strengthening activities, hamstrings stretching, and spine range of motion exercises. Patients meeting inclusion criteria were contacted via phone interview and asked to complete an Oswestry Disability Questionnaire (ODQ) in order to generate a disability score to assess their current pain and daily function. Patients were then stratified into groups based on their level of disability as denoted by their disability score; minimal disability = disability score of 0% to 19.9%, moderate disability = 20% to 39.9%, severe disability = 40% to 59.9%, crippled = 60% to 79.9%, and bed bound or exaggerating = 80% to 100%. RESULTS: Fourty-six patients were identified as meeting inclusion criteria (28 with SP and 18 with SPL1). Twenty-three of 46 were successfully contacted and agreed to complete the ODQ (10/23 with SP and 13/23 with SPL1). Twenty-two of 23 (96%) patients had a minimal disability score (0% to 19.9%), One of 23 (4%) patients had a moderate disability score (20% to 39.9%), and 18/23 (78%) patients had a disability score of zero, denoting no pain or limitation of function. CONCLUSION: The results of this study suggest that, in patients with symptomatic spondylolysis and grade I spondylolisthesis, pain relief and restoration of function can be achieved using conservative management techniques without use of a brace.


Assuntos
Tratamento Conservador/métodos , Terapia por Exercício/métodos , Dor Lombar , Recuperação de Função Fisiológica , Espondilolistese , Espondilólise , Adolescente , Adulto , Estudos Transversais , Avaliação da Deficiência , Feminino , Humanos , Dor Lombar/diagnóstico , Dor Lombar/etiologia , Dor Lombar/terapia , Masculino , Avaliação de Resultados da Assistência ao Paciente , Modalidades de Fisioterapia , Espondilolistese/fisiopatologia , Espondilolistese/terapia , Espondilólise/fisiopatologia , Espondilólise/terapia , Inquéritos e Questionários , Avaliação de Sintomas
13.
J Pediatr Orthop B ; 28(1): 27-31, 2019 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-30256316

RESUMO

Accelerated discharge protocols for scoliosis surgery have recently been described in the literature. There are limited data describing the association of length of stay (LOS) during the index admission with postoperative outcomes. We sought to define the economic and clinical implications of an additional 1 day in the hospital for scoliosis surgery. The Statewide Planning and Research Cooperative System database was used to identify patients with adolescent idiopathic scoliosis who underwent spinal fusion from 1 October 2007 to 30 September 2012 at high-volume institutions (>20 cases/year) in the state of New York. Regression models were adjusted for age, sex, race, insurance, comorbidity score, and perioperative complications during the index admission. Among the 1286 patients with AIS who underwent spinal fusion, the mean LOS was 4.90 days [95% confidence interval (CI)=4.84-4.97; SD=1.19]. In the perioperative period, 605 (47.05%) underwent transfusion and 202 (15.71%) had problems with pain control. An additional 1 day in the hospital was associated with $11 033 (95% CI=7162-14 904; P<0.001) in insurance charges, $5198 (95% CI=4144-6252; P<0.001) in hospital costs, 28% increased risk (odds ratio=1.28; 95% CI=1.01-1.63; P=0.041) of all-cause 90-day readmission, and a 57% increased risk (odds ratio=1.57; 95% CI=1.13-2.17; P=0.007) of returning to the operating room within 90 days. Increased LOS during the index admission scoliosis surgery is associated with higher costs and an increased risk of 90-day postoperative complications. Protocols to decrease LOS for this surgery have potential benefits to patients, hospitals, and insurers. Level of Evidence: Level III, retrospective comparative study.


Assuntos
Tempo de Internação/economia , Tempo de Internação/estatística & dados numéricos , Escoliose/cirurgia , Adolescente , Transfusão de Sangue/estatística & dados numéricos , Criança , Feminino , Preços Hospitalares/estatística & dados numéricos , Custos Hospitalares/estatística & dados numéricos , Humanos , Masculino , New York/epidemiologia , Readmissão do Paciente/estatística & dados numéricos , Complicações Pós-Operatórias/epidemiologia , Reoperação/estatística & dados numéricos , Estudos Retrospectivos , Risco , Fusão Vertebral , Adulto Jovem
14.
J Pediatr Orthop B ; 27(6): 551-555, 2018 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-29957617

RESUMO

The goal of this study was to compare open reduction versus percutaneous fixation of adolescent ankle fractures with regards to the incidence of growth disturbance. We performed a retrospective cohort analysis of adolescent patients with triplane or Tillaux fractures. There was an even distribution of triplane fractures and mean initial displacement between cohorts. Analysis of follow-up radiographs revealed no instances of growth disturbance in the percutaneous fixation group and six in the open reduction group (P=0.29). Growth disturbance does not pose a significant concern when selecting a surgical approach. Owing to the rarity of these fractures this study was underpowered.


Assuntos
Fixação de Fratura/métodos , Redução Aberta/métodos , Fraturas da Tíbia/diagnóstico por imagem , Fraturas da Tíbia/cirurgia , Adolescente , Criança , Estudos de Coortes , Feminino , Fixação de Fratura/normas , Humanos , Masculino , Redução Aberta/normas , Estudos Retrospectivos
15.
Sci Rep ; 8(1): 5777, 2018 04 10.
Artigo em Inglês | MEDLINE | ID: mdl-29636522

RESUMO

Hunger evokes stereotypic behaviors that favor the discovery of nutrients. The neural pathways that coordinate internal and external cues to motivate foraging behaviors are only partly known. Drosophila that are food deprived increase locomotor activity, are more efficient in locating a discrete source of nutrition, and are willing to overcome adversity to obtain food. We developed a simple open field assay that allows flies to freely perform multiple steps of the foraging sequence, and we show that two distinct dopaminergic neural circuits regulate measures of foraging behaviors. One group, the PAM neurons, functions in food deprived flies while the other functions in well fed flies, and both promote foraging. These satiation state-dependent circuits converge on dopamine D1 receptor-expressing Kenyon cells of the mushroom body, where neural activity promotes foraging independent of satiation state. These findings provide evidence for active foraging in well-fed flies that is separable from hunger-driven foraging.


Assuntos
Drosophila/fisiologia , Privação de Alimentos , Locomoção , Corpos Pedunculados/metabolismo , Neurônios/metabolismo , Saciação , Animais , Dopamina/metabolismo , Drosophila/metabolismo , Comportamento Alimentar , Masculino , Vias Neurais
16.
ASAIO J ; 64(3): 301-308, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28953199

RESUMO

Proper timing of left ventricular assist device (LVAD) implantation in advanced heart failure patients is not well established and is an area of intense interest. In addition, optimizing LVAD performance after implantation remains difficult and represents a significant clinical need. Implantable hemodynamic monitoring systems may provide physicians with the physiologic information necessary to improve the timing of LVAD implantation as well as LVAD performance when compared with current methods. The CardioMEMS Heart sensor Allows for Monitoirng of Pressures to Improve Outcomes in NYHA Class III heart failure patients (CHAMPION) Trial enrolled 550 previously hospitalized patients with New York Heart Association (NYHA) class III heart failure. All patients were implanted with a pulmonary artery (PA) pressure monitoring system and randomized to a treatment and control groups. In the treatment group, physicians used the hemodynamic information to make heart failure management decisions. This information was not available to physicians for the control group. During an average of 18 month randomized follow-up, 27 patients required LVAD implantation. At the time of PA pressure sensor implantation, patients ultimately requiring advanced therapy had higher PA pressures, lower systemic pressure, and similar cardiac output measurements. Treatment and control patients in the LVAD subgroup had similar clinical profiles at the time of enrollment. There was a trend toward a shorter length of time to LVAD implantation in the treatment group when hemodynamic information was available. After LVAD implantation, most treatment group patients continued to provide physicians with physiologic information from the hemodynamic monitoring system. As expected PA pressures declined significantly post LVAD implant in all patients, but the magnitude of decline was higher in patients with PA pressure monitoring. Implantable hemodynamic monitoring appeared to improve the timing of LVAD implantation as well as optimize LVAD performance when compared with current methods. Further studies are necessary to evaluate these findings in a prospective manner.


Assuntos
Insuficiência Cardíaca/fisiopatologia , Insuficiência Cardíaca/terapia , Coração Auxiliar , Monitorização Hemodinâmica/instrumentação , Tecnologia sem Fio/instrumentação , Feminino , Coração Auxiliar/efeitos adversos , Hemodinâmica/fisiologia , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos
17.
J Pediatr Orthop ; 37(3): 178-183, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-26192882

RESUMO

BACKGROUND: There is a dearth of literature examining the causes of cam-type femoroacetabular impingement (FAI) and when such morphology appears. The purpose of the current study was to analyze how the ossific portion of the proximal femur develops over time with respect to standard cam-type FAI parameters. METHODS: A collection of 193 femurs from cadavers aged 4 to 21 years were evaluated. The age, sex, ethnicity, and status of the proximal femoral physes (open or closed) of each were recorded. Each specimen was digitally photographed in standardized anteroposterior and modified axial positions. From these photographs, the anterior offset, anterior offset ratio (AOR), and α-angle were determined. A cam lesion was defined as an α-angle >55 degrees on the lateral view. RESULTS: The mean age of the specimens was 17.5±4.2 years. The majority were male (69%) and African American (79%) with closed physes (78%). There were significant differences among discrete age groups with respect to α-angle (P=0.01), anterior offset (P<0.01), and AOR (P<0.01). In addition, younger femurs with open physes had a significantly higher mean α-angle (P<0.01), lower mean anterior offset (P<0.01), and higher mean AOR (P<0.01) compared with older ones with closed physes. Specimens defined as having a cam deformity had a statistically higher α-angle (P<0.01) and lower anterior offset (P<0.01), but there was no difference in AOR values compared with specimens without a cam lesion (P=0.1). CONCLUSIONS: The apparent decline in α-angles as age increases indicates that the traditional α-angle in younger patients measures a different anatomic parameter (ossified femur excluding the cartilaginous portion) than in older patients (completely ossified femur). This suggests that the bony α-angle is inappropriate in the evaluation of cam lesions in the immature physis. The AOR, rather than the anterior offset, may be more accurate in the evaluation of the growing proximal femur. CLINICAL RELEVANCE: This study provides novel insight into, and enhances the understanding of, the development of cam-type FAI.


Assuntos
Impacto Femoroacetabular/etiologia , Impacto Femoroacetabular/patologia , Adolescente , Adulto , Fatores Etários , Cadáver , Criança , Pré-Escolar , Feminino , Fêmur/patologia , Lâmina de Crescimento/patologia , Articulação do Quadril/patologia , Humanos , Masculino , Adulto Jovem
18.
J Pediatr Orthop ; 37(1): 47-52, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-26196495

RESUMO

BACKGROUND: Dysplastic hip may present with acetabular retroversion with or without femoral retroversion. This retroversion, if not accounted for when performing a periacetabular osteotomy (PAO), will lead to anterior hip pain and early osteoarthritis. A reverse PAO involves anteverting the acetabulum while still obtaining lateral coverage. The purpose of this study was to investigate the relationship between rotational malalignment of acetabulum and femur on 2-dimensional computed tomographic (CT) scans of hips that underwent Bernese PAO and its role in the surgical decision making. METHODS: This retrospective, case-control study examined and compared preoperative 2-dimensional CT scans of hips that underwent reverse PAO to the hips that underwent traditional PAO. RESULTS: Twelve hips underwent reverse PAO from 2005 to 2010. Twelve hips were randomly selected from a cohort of 52 hips that underwent traditional PAO during same time period. Hips that underwent reverse PAO showed crossover sign on preoperative radiographs, but not on postoperative radiographs. Crossover sign was negative preoperatively and postoperatively on hips that underwent traditional PAO. The 2 groups were similar in regards to preoperative lateral center-edge angle, acetabular index, and anterior center-edge angle on plain radiographs and showed significant improvement after surgery.On preoperative CT scans both acetabulae and femurs were retroverted in reverse PAO group. Comparison of the 2 groups demonstrated that acetabular version (16.5±4.9 degrees vs. 25.3±5.6 degrees, P=0.001), femoral version (12.8±10.4 degrees vs. 31.9±8 degrees, P<0.001), and McKibbins Instability Index (29.3±11.9 degrees vs. 57.1±9.8 degrees, P<0.001) were significantly lower for the reverse PAO than the traditional PAO group. Anterior Acetabular Sector Angle (determines anterior coverage) was significantly higher in reverse PAO group, 53.1±13.7 degrees versus 39.7±10.4 degrees (P=0.013). CONCLUSIONS: Retroverted acetabulae seem to be associated with reduced femoral version. Given that retroverted acetabulum and retroverted femur have additive effect and increase chances of anterior hip pain, preoperative identification of correct acetabular, and femoral version by CT scan or MRI is necessary to determine which hip need reverse PAO as opposed to traditional PAO. LEVEL OF EVIDENCE: Level III-Therapeutic.


Assuntos
Acetábulo/diagnóstico por imagem , Fêmur/diagnóstico por imagem , Luxação do Quadril/diagnóstico por imagem , Articulação do Quadril/diagnóstico por imagem , Osteotomia/métodos , Acetábulo/cirurgia , Adolescente , Adulto , Estudos de Casos e Controles , Criança , Feminino , Luxação do Quadril/cirurgia , Articulação do Quadril/cirurgia , Humanos , Imageamento por Ressonância Magnética , Masculino , Radiografia , Amplitude de Movimento Articular , Estudos Retrospectivos , Tomografia Computadorizada por Raios X , Adulto Jovem
19.
J Pediatr Orthop ; 37(3): 166-170, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-26214326

RESUMO

BACKGROUND: Postoperative wound complications after posterior spinal fusion are difficult to manage. The incidence in the nonidiopathic patient population is significantly higher than the adolescent idiopathic population. A comparison of wound complications after posterior spinal fusion for nonidiopathic scoliosis between the utilization of the orthopaedic surgical team at the time of closure performing a nonstandardized wound closure versus a plastic surgeon with a plastic multilayered closure technique and rotational flap coverage when needed had not previously been evaluated. The purpose of this study was to compare the complication rate between nonstandardized and plastic multilayered closure of the surgical incision in patients undergoing posterior spinal fusion for nonidiopathic scoliosis. METHODS: The charts of 76 patients with a primary diagnosis of scoliosis associated with a syndrome or neuromuscular disease and who underwent a posterior spinal fusion were reviewed. Forty-two patients had their incisions closed using the nonstandardized technique and 34 using the plastic multilayered technique. These 2 groups were compared for age, sex, primary diagnosis, number of levels fused, estimated blood loss, number of units transfused, operating room time, wound complication, and return to operating room. RESULTS: The wound complication rate in the nonstandardized closure group was 19% (8/42) compared with 0% (0/34) in the plastic multilayered closure group (P=0.007). The unanticipated return to the operating room rate was 11.9% (5/42) for the nonstandardized closure patients versus 0% (0/34) for the plastic multilayered closure patients (P=0.061). CONCLUSIONS: The use of the plastic multilayered closure technique in this patient population is important in an effort to decrease postoperative wound complications. The ability of the surgical team to decrease the infection rate of nonidiopathic scoliosis cannot be overstated. The method of wound closure plays a major role in lowering this incidence. LEVEL OF EVIDENCE: Level III-therapeutic.


Assuntos
Ortopedia/métodos , Complicações Pós-Operatórias , Escoliose/cirurgia , Fusão Vertebral , Técnicas de Fechamento de Ferimentos , Adolescente , Criança , Feminino , Humanos , Incidência , Masculino , Músculo Esquelético/cirurgia , Complicações Pós-Operatórias/etiologia , Estudos Retrospectivos , Fusão Vertebral/efeitos adversos , Fusão Vertebral/métodos , Retalhos Cirúrgicos , Resultado do Tratamento
20.
Bull Hosp Jt Dis (2013) ; 74(4): 249-253, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27815946

RESUMO

Gradual distal fibula lengthening (DFL), in conjunction with other procedures, was used to correct ankle valgus and short fibulae in three pediatric patients with multiple hereditary exostoses (MHE). The average amount of DFL was 15 mm with a mean follow-up of 2.9 years. Final radiographs showed that all three patients had a stable ankle mortise without evidence of talar tilt or widening. In conclusion, gradual DFL has the advantage of restoring anatomy in cases of ankle valgus due to short fibulae and MHE, and may be performed in conjunction with other procedures.


Assuntos
Articulação do Tornozelo/cirurgia , Exostose Múltipla Hereditária/cirurgia , Fíbula/cirurgia , Deformidades Adquiridas do Pé/cirurgia , Osteogênese por Distração , Tíbia/cirurgia , Adolescente , Articulação do Tornozelo/diagnóstico por imagem , Articulação do Tornozelo/fisiopatologia , Fenômenos Biomecânicos , Remodelação Óssea , Parafusos Ósseos , Criança , Exostose Múltipla Hereditária/diagnóstico por imagem , Exostose Múltipla Hereditária/fisiopatologia , Fíbula/diagnóstico por imagem , Fíbula/fisiopatologia , Deformidades Adquiridas do Pé/diagnóstico , Deformidades Adquiridas do Pé/fisiopatologia , Humanos , Masculino , Osteogênese por Distração/instrumentação , Recuperação de Função Fisiológica , Estudos Retrospectivos , Tíbia/diagnóstico por imagem , Tíbia/fisiopatologia , Fatores de Tempo , Resultado do Tratamento
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