RESUMO
This project is to develop a comprehensive master plan incorporating key principles of sustainable urbanism for a business district in Houston, Texas, USA. The main design objectives are to create a livable and sustainable urban business center, to promote economic growth and to implement a streetscape design guideline to promote walkability and bikeability.
RESUMO
A highly π-facial selective and regioselective fluorination of chiral enamides is described. The reaction involves an enantioselective fluorination exclusively at the electron-rich enamide olefin with N-F reagents such as Selectfluor and N-fluoro-benzenesulfonimide [NFSI] accompanied by trapping of the ß-fluoro-iminium cationic intermediate with water. The resulting N,O-hemiacetal could be oxidized using Dess-Martin periodinane, leading to an asymmetric sequence for syntheses of chiral α-fluoro-imides and optically enriched α-fluoro-ketones.
Assuntos
Amidas/síntese química , Hidrocarbonetos Fluorados/síntese química , Amidas/química , Catálise , Técnicas de Química Combinatória , Cristalografia por Raios X , Hidrocarbonetos Fluorados/química , Hidrocarbonetos Iodados/química , Conformação Molecular , Estrutura Molecular , EstereoisomerismoRESUMO
A tandem sequence of 5-endo halolactamization and direct C-H oxidative functionalization is described. A range of ß-halo-pyrrolidinones can be efficiently synthesized using this method, making it an excellent approach for constructing natural products containing pyrrolidinones.