1.
Chemistry
; 27(44): 11285-11290, 2021 Aug 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34009722
RESUMO
ϵ-Benzosultam derivatives are potential drug candidates with diverse biological activities. A series of chiral ϵ-benzosultams bearing phosphorus functionalities was synthesized by catalytic asymmetric hydrophosphonylation in the presence of a bifunctional phosphonium salt catalyst. The desired hydrophosphonylation products were obtained in good yields with high enantioselectivities, and scale-up reactions and further derivations were successfully accomplished. Some control experiments were also conducted to elucidate the plausible reaction mechanism of this chemical transformation.