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1.
Front Immunol ; 14: 1206979, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37876932

RESUMO

Introduction: Infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces rapid production of IgM, IgA, and IgG antibodies directed to multiple viral antigens that may have impact diverse clinical outcomes. Methods: We evaluated IgM, IgA, and IgG antibodies directed to the nucleocapsid (NP), IgA and IgG to the Spike protein and to the receptor-binding domain (RBD), and the presence of neutralizing antibodies (nAb), in a cohort of unvaccinated SARS-CoV-2 infected individuals, in the first 30 days of post-symptom onset (PSO) (T1). Results: This study included 193 coronavirus disease 2019 (COVID-19) participants classified as mild, moderate, severe, critical, and fatal and 27 uninfected controls. In T1, we identified differential antibody profiles associated with distinct clinical presentation. The mild group presented lower levels of anti-NP IgG, and IgA (vs moderate and severe), anti-NP IgM (vs severe, critical and fatal), anti-Spike IgA (vs severe and fatal), and anti-RBD IgG (vs severe). The moderate group presented higher levels of anti-RBD IgA, comparing with severe group. The severe group presented higher levels of anti-NP IgA (vs mild and fatal) and anti-RBD IgG (vs mild and moderate). The fatal group presented higher levels of anti-NP IgM and anti-Spike IgA (vs mild), but lower levels of anti-NP IgA (vs severe). The levels of nAb was lower just in mild group compared to severe, critical, and fatal groups, moreover, no difference was observed among the more severe groups. In addition, we studied 82 convalescent individuals, between 31 days to 6 months (T2) or more than 6 months (T3), PSO, those: 12 mild, 26 moderate, and 46 severe plus critical. The longitudinal analyzes, for the severe plus critical group showed lower levels of anti-NP IgG, IgA and IgM, anti-Spike IgA in relation T3. The follow-up in the fatal group, reveals that the levels of anti-spike IgG increased, while anti-NP IgM levels was decreased along the time in severe/critical and fatal as well as anti-NP IgG and IgA in several/critical groups. Discussion: In summary, the anti-NP IgA and IgG lower levels and the higher levels of anti-RBD and anti-Spike IgA in fatal compared to survival group of individuals admitted to the intensive care unit (ICU). Collectively, our data discriminate death from survival, suggesting that anti-RBD IgA and anti-Spike IgA may play some deleterious effect, in contrast with the potentially protective effect of anti-NP IgA and IgG in the survival group.


Assuntos
COVID-19 , Humanos , SARS-CoV-2 , Anticorpos Antivirais , Anticorpos Neutralizantes , Nucleocapsídeo , Imunoglobulina G , Imunoglobulina A , Imunoglobulina M
2.
Rev Soc Bras Med Trop ; 50(3): 379-382, 2017.
Artigo em Inglês | MEDLINE | ID: mdl-28700057

RESUMO

INTRODUCTION:: The incidence of dengue has increased throughout the 2000s with a consequent global increase in atypical clinical forms. METHODS:: This study reports a series of cases of neurological dengue out of 498 confirmed cases of laboratory dengue in Goiânia, Brazil. Cases were confirmed based on viral RNA detection via polymerase chain reaction or IgM antibody capture. RESULTS:: Neurological symptoms occurred in 5.6% of cases, including paresthesia (3.8%), encephalitis (2%), encephalopathy (1%), seizure (0.8%), meningoencephalitis (0.4%), and paresis (0.4%). DENV-3 was the predominant circulating serotype (93%). CONCLUSIONS:: We reported dengue cases with neurological manifestations in endemic area.


Assuntos
Dengue/complicações , Encefalite Viral/virologia , Meningoencefalite/virologia , Parestesia/virologia , Adolescente , Adulto , Idoso , Anticorpos Antivirais/sangue , Brasil/epidemiologia , Pré-Escolar , Dengue/epidemiologia , Vírus da Dengue/genética , Vírus da Dengue/imunologia , Encefalite Viral/epidemiologia , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Masculino , Meningoencefalite/epidemiologia , Pessoa de Meia-Idade , Parestesia/epidemiologia , Reação em Cadeia da Polimerase , RNA Viral/genética , Adulto Jovem
3.
Rev. Soc. Bras. Med. Trop ; 50(3): 379-382, May-June 2017. tab
Artigo em Inglês | LILACS | ID: biblio-1041413

RESUMO

Abstract INTRODUCTION: The incidence of dengue has increased throughout the 2000s with a consequent global increase in atypical clinical forms. METHODS: This study reports a series of cases of neurological dengue out of 498 confirmed cases of laboratory dengue in Goiânia, Brazil. Cases were confirmed based on viral RNA detection via polymerase chain reaction or IgM antibody capture. RESULTS: Neurological symptoms occurred in 5.6% of cases, including paresthesia (3.8%), encephalitis (2%), encephalopathy (1%), seizure (0.8%), meningoencephalitis (0.4%), and paresis (0.4%). DENV-3 was the predominant circulating serotype (93%). CONCLUSIONS: We reported dengue cases with neurological manifestations in endemic area.


Assuntos
Humanos , Masculino , Feminino , Idoso , Parestesia/virologia , Ensaio de Imunoadsorção Enzimática , Encefalite Viral/virologia , Dengue/complicações , Dengue/epidemiologia , Meningoencefalite/virologia , Parestesia/epidemiologia , Brasil/epidemiologia , RNA Viral/genética , Reação em Cadeia da Polimerase , Encefalite Viral/epidemiologia , Vírus da Dengue/genética , Vírus da Dengue/imunologia , Meningoencefalite/epidemiologia , Pessoa de Meia-Idade , Anticorpos Antivirais/sangue
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