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The embrace of coronavirus disease 2019 (COVID-19) vaccine conspiracies has been linked to vaccine hesitancy. This study aimed to investigate the relationship between COVID-19 vaccine conspiracy theories and perceived vaccine effectiveness. The study utilized a longitudinal follow-up study in which adults in Chile completed surveys in December 2020 (T1) and May 2021 (T2). The psychometric properties of the five-item instrument on conspiracy theories for the COVID-19 vaccine were evaluated using data from T1 (n = 578). A confirmatory one-factor structure with suitable indicators of reliability was found. The longitudinal analysis (n = 292) revealed that conspiracy theories about the COVID-19 vaccine in T1 were associated with lower beliefs in its effectiveness in T2. However, no significant association was found between beliefs in effectiveness in T1 and conspiracy theories in T2. The study suggests that beliefs in conspiracy theories may temporally precede beliefs in vaccine effectiveness for COVID-19. The results have implications for strategies to address vaccine conspiracy beliefs and their implementation at the public policy level.
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[This corrects the article DOI: 10.3389/fmicb.2022.862812.].
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Introducción: La pandemia por COVID-19 ha tenido un impacto negativo en el bienestar psicológico de la población, siendo los jóvenes un grupo especialmente vulnerable. Objetivo: El presente estudio se propuso examinar los niveles de búsqueda de ayuda (formal e informal) para problemas en salud mental y sus variables asociadas en una muestra de estudiantes universitarios de la Región de La Araucanía, en el contexto de la pandemia por COVID-19. Método: A través de un muestreo no probabilístico por conveniencia, se reclutó a 500 estudiantes de entre 18 y 29 años. Se describió y comparó su nivel de búsqueda de ayuda, así como variables que podrían obstaculizarla o facilitarla, según género. Adicionalmente, se estimaron modelos de regresión lineal múltiple diferenciados por género, con la búsqueda de ayuda informal como variable criterio. Resultados: Se evidenció una renuencia general a buscar ayuda (formal e informal) tanto en hombres como mujeres, una mayor experimentación de malestar psicológico y mayor conocimiento sobre salud mental en mujeres. Finalmente, se observaron diferencias en los predictores de la búsqueda de ayuda informal entre hombres y mujeres, siendo el apoyo social y las emociones negativas en pandemia los únicos comunes entre géneros. Conclusión: Se discuten los bajos niveles de búsqueda de ayuda evidenciados, y las diferencias observadas en variables asociadas, en función de la brecha de género en salud mental.
Introduction: The COVID-19 pandemic has impacted the psychological well-being of the population, with young people being a particularly vulnerable group. Aim: The present study examines help-seeking intention for mental health problems and associated variables among male and female university students in La Araucanía Region during the COVI-19 pandemic. Method: A sample of 500 students aged 18 to 29 was recruited through non-probabilistic convenience sampling. Help-seeking levels and facilitating or hindering variables were compared by gender. Multiple linear regression models were estimated separately by gender to predict the criterion variable of informal help-seeking. Results: The results indicate that both men and women are reluctant to seek help (formal and informal). Women reported higher levels of psychological distress and greater knowledge about mental health than men. Differences in predictors of informal help-seeking between men and women are evidenced, with social support and negative emotions in pandemic being the only common predictors between genders. Conclusion: The low levels of help-seeking evidenced, and the differences observed in associated variables based on the gender gap in mental health, are discussed.
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Humanos , Masculino , Feminino , Adolescente , Adulto , Adulto Jovem , Estudantes/psicologia , Comportamento de Busca de Ajuda , COVID-19 , Ansiedade , Estresse Psicológico , Chile , Depressão , Pandemias , Bem-Estar PsicológicoRESUMO
Health inequities exist in groups of greater psychosocial vulnerability such as emerging adults and migrants. The study aimed to generate evidence of the validity of the mental and physical health symptomatology scale in two samples of vulnerable groups: emerging university adults, who report high levels of mental health problems, and migrants, who report high levels of physical and mental health problems. Using non-probability sampling, in the first study, evidence of construct validity of the scale was reported in 652 emerging adults and, in the second, evidence of validity was provided from associations with the depression, stress and anxiety scale (DASS-21) among 283 migrants. The results indicate that in Study 1 the two-factor model had adequate indicators of fit and adequate reliability; only the mental health factor presented evidence of convergent validity. In Study 2, the mental health factor showed positive and large associations with the DASS-21, which decreased when the physical health symptoms factor was considered. These analyses provide evidence of validity for the scale, which is an easy-to-use instrument that allows for the assessment of health from an integral perspective.
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Saúde Mental , Estresse Psicológico , Humanos , Adulto , Chile/epidemiologia , Reprodutibilidade dos Testes , Estresse Psicológico/diagnóstico , Exame Físico , Depressão/psicologiaRESUMO
BACKGROUND: The modulation hypothesis of facial feedback has not adequately examined how combining facial expressions and bodily postures might influence our experience of emotional stimuli. This pilot study examined a new method for manipulating both face and body together, which is important in furthering our understanding of how face and body interact to influence emotional experiences in the real world. METHODS: Using a within-subjects design, 30 participants viewed positive film clips under four conditions: (1) positive face with positive body (PP), (2) positive face with neutral body (PN), (3) neutral face with positive body (NP) and (4) neutral face with neutral body (NN). Measures of positive and negative affect were taken before and after each clip, to assess the subjective emotional experience. RESULTS: Repeated-measures analysis of variance (ANOVA) was conducted to examine differences in the emotional experience under each condition. Post hoc pairwise comparisons demonstrated that positive affect in the PP condition was significantly higher than in the NP and NN conditions. There was no significant difference between the PP and NN conditions. CONCLUSION: Whilst the study findings are difficult to interpret, this pilot study generated a number of important methodological learnings that are relevant to future research of this kind.
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Emoções , Expressão Facial , Afeto , Retroalimentação , Projetos Piloto , PosturaRESUMO
The role of perceived social support in the acculturation process of immigrants remains unclear. In this study, we jointly evaluated the associations between acculturative stress and negative emotions associated with discrimination as antecedents of anxiety, depression, and stress symptoms in 283 immigrants living in Chile. Three competing models were tested via structural equation modelling to assess (1) the association among these variables and mental health symptoms and (2) to clarify the role of perceived social support. The third model was theoretically more adequate, showed a better fit, and explained 42.7% of the variance of mental health symptoms. In this model, perceived social support was associated with acculturative stress by reducing mental health symptomatology. Moreover, a direct relationship and an indirect relationship were found between acculturative stress (through negative emotions associated with discrimination) and mental health symptomatology. These results contribute to the understanding of the acculturation process experienced by immigrants in Chile and provide empirical evidence to be used to improve migration policies.
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Emigrantes e Imigrantes , Saúde Mental , Estresse Psicológico/psicologia , Aculturação , Ansiedade , Apoio SocialRESUMO
BACKGROUND: Negative beliefs about vaccines can threaten herd immunity and pandemic control. Although beliefs about vaccines influence vaccination intention, there are no valid instruments that evaluate this in the Latin American population. AIM: To evaluate the psychometric properties of two scales that measure negative beliefs towards vaccines in general and against SARS-CoV-2 and provide evidence of their association with vaccination intention (convergent validity) in a Chilean sample. MATERIAL AND METHODS: Two studies were carried out. The first included 263 people who answered the beliefs towards vaccines in general scale (CV-G) and the beliefs towards the SARS-CoV-2 vaccine scale (CV-COVID). Exploratory factor analyses were conducted. In the second study, 601 people answered the same scales. Confirmatory factor analyses and structural equation modeling were performed to provide evidence of validity. RESULTS: Both scales had an unifactorial structure and excellent reliability and showed associations with the intention of vaccination against SARS-CoV-2, providing evidence of convergent validity. CONCLUSIONS: The scales evaluated here are reliable and valid measures that showed associations with vaccination intention in the Chilean population.
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Humanos , Vacinas , COVID-19/prevenção & controle , Psicometria , Reprodutibilidade dos Testes , Vacinação , Intenção , Vacinas contra COVID-19 , SARS-CoV-2RESUMO
BACKGROUND: Negative beliefs about vaccines can threaten herd immunity and pandemic control. Although beliefs about vaccines influence vaccination intention, there are no valid instruments that evaluate this in the Latin American population. Aim: To evaluate the psychometric properties of two scales that measure negative beliefs towards vaccines in general and against SARS-CoV-2 and provide evidence of their association with vaccination intention (convergent validity) in a Chilean sample. MATERIAL AND METHODS: Two studies were carried out. The first included 263 people who answered the beliefs towards vaccines in general scale (CV-G) and the beliefs towards the SARS-CoV-2 vaccine scale (CV-COVID). Exploratory factor analyses were conducted. In the second study, 601 people answered the same scales. Confirmatory factor analyses and structural equation modeling were performed to provide evidence of validity. RESULTS: Both scales had an unifactorial structure and excellent reliability and showed associations with the intention of vaccination against SARS-CoV-2, providing evidence of convergent validity. Conclusions: The scales evaluated here are reliable and valid measures that showed associations with vaccination intention in the Chilean population.
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Humanos , Vacinas , COVID-19/prevenção & controle , Psicometria , Reprodutibilidade dos Testes , Vacinação , Intenção , Vacinas contra COVID-19 , SARS-CoV-2RESUMO
Inflammatory bowel disease (IBD) is characterized by dysregulated intestinal immune responses. Using mass cytometry (CyTOF) to analyze the immune cell composition in the lamina propria (LP) of patients with ulcerative colitis (UC) and Crohn's disease (CD), we observed an enrichment of CD4+ effector T cells producing IL-17A and TNF, CD8+ T cells producing IFNγ, T regulatory (Treg) cells, and innate lymphoid cells (ILC). The function of these immune cells is regulated by store-operated Ca2+ entry (SOCE), which results from the opening of Ca2+ release-activated Ca2+ (CRAC) channels formed by ORAI and STIM proteins. We observed that the pharmacologic inhibition of SOCE attenuated the production of proinflammatory cytokines including IL-2, IL-4, IL-6, IL-17A, TNF, and IFNγ by human colonic T cells and ILCs, reduced the production of IL-6 by B cells and the production of IFNγ by myeloid cells, but had no effect on the viability, differentiation, and function of intestinal epithelial cells. T cell-specific deletion of CRAC channel genes in mice showed that Orai1, Stim1, and Stim2-deficient T cells have quantitatively distinct defects in SOCE, which correlate with gradually more pronounced impairment of cytokine production by Th1 and Th17 cells and the severity of IBD. Moreover, the pharmacologic inhibition of SOCE with a selective CRAC channel inhibitor attenuated IBD severity and colitogenic T cell function in mice. Our data indicate that SOCE inhibition may be a suitable new approach for the treatment of IBD.
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Canais de Cálcio Ativados pela Liberação de Cálcio , Doenças Inflamatórias Intestinais , Animais , Linfócitos T CD8-Positivos/metabolismo , Cálcio/metabolismo , Canais de Cálcio/metabolismo , Humanos , Imunidade Inata , Interleucina-17/metabolismo , Interleucina-6/metabolismo , Camundongos , Proteína ORAI1/metabolismo , Molécula 1 de Interação Estromal/genética , Células Th17/metabolismoRESUMO
The COVID-19 pandemic has had a significant impact on daily life, affecting both physical and mental health. Changes arising from the pandemic may longitudinally impact health-related behaviors (HRB). As different HRBs co-occur, in this study, we explore how six HRBs - alcohol (past-week and binge-drinking), tobacco, marijuana, benzodiazepine use, and unhealthy food consumption - were grouped and changed over time during the COVID-19 pandemic. A sample of 1038 university students and staff (18 to 73 years old) of two universities completed an online psychometrically adequate survey regarding their recalled HRB (T0, pre-COVID-19 pandemic) and the impact of COVID-19 on their behaviors during July (T1) and November (T2). Latent Transition Analysis (LTA) was used to identify HRB cluster membership and how clusters changed across T0, T1, and T2. Four clusters emerged, but remained mainly stable over time: 'Lower risk' (65.2-80%), 'Smokers and drinkers' (1.5-0.01%), 'Binge-drinkers and marijuana users' (27.6-13.9%), and 'Smokers and binge-drinkers' (5.6-5.8%). Participants who moved from one cluster to another lowered their HRB across time, migrating from the 'Binge-drinkers and marijuana users' cluster to 'Lower risk'. Participants in this cluster were characterized as less affected economically by the COVID-19 pandemic, with lower reported stress levels, anxiety, depression, and loneliness than the other clusters. Our results provide evidence of how HRBs clustered together and transitioned longitudinally during the COVID-19 pandemic. HRB clustering across time offers a valuable piece of information for the tailoring of interventions to improve HRB.
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COVID-19 , Adolescente , Adulto , Idoso , COVID-19/epidemiologia , Análise por Conglomerados , Comportamentos Relacionados com a Saúde , Humanos , Pessoa de Meia-Idade , Pandemias , Universidades , Adulto JovemRESUMO
(1) Background: Although the evidence is consistent that vaccines for COVID-19 effectively prevent severe illness or death, the rapid development of vaccines has led to increased beliefs about possible negative consequences and conspiracy theories about the vaccine. Several factors influence whether or not people decide to be vaccinated. Some studies suggest that our perception of what significant others do and think influences our behavior. (2) Methods: This study evaluates the predictive role of beliefs about negative consequences of the COVID-19 vaccine, conspiracy beliefs about this vaccine, and social influence on the intention to vaccinate against COVID-19 in three Latin American and Caribbean countries: Chile, Mexico, and Colombia. Using convenience sampling, 2075 adults from Chile (48.3%), Mexico (27.6%), and Colombia (24.6%) participated by answering an online questionnaire with variables of interest. (3) Results: Despite the differences between countries, the results showed that the proposed model is invariant and explains between 56-66% of the COVID-19 vaccination intent. Specifically, controlling for age, socioeconomic status, political orientation, and educational level, we found that beliefs about the negative consequences of the COVID-19 vaccine were the main predictor followed by social influence. Beliefs in conspiracy theories did not predict vaccination intention (4) Conclusions: Considering these variables in campaigns to boost vaccination intention is discussed.
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The giant mussel Choromytilus chorus is a marine bivalve commonly collected in central - southern Chile from fishery zones shared with the salmon industry. These economically relevant areas are also affected by the use of pesticides for controlling sea lice infestations in salmon aquaculture. Their main target is the sea louse Caligus rogercresseyi. However, other than some physiological impacts, the molecular effects of delousing drugs in non-target species such as C. chorus remain largely understudied. This study aimed to explore the transcriptome modulation of Trochophore and D larvae stages of C. chorus after exposure to azamethiphos and deltamethrin drugs. Herein, RNA-seq analyses and mRNA-lncRNAs molecular interactions were obtained. The most significant changes were found between different larval development stages exposed to delousing drugs. Notably, significant transcriptional variations were correlated with the drug concentrations tested. The biological processes involved in the development, such as cell movement and transcriptional activity, were mainly affected. Long non-coding RNAs (lncRNAs) were also identified in this species, and the transcription activity showed similar patterns with coding mRNAs. Most of the significantly expressed lncRNAs were associated with genes annotated to matrix metalloproteinases, collagenases, and transcription factors. This study suggests that exposure to azamethiphos or deltamethrin drugs can modulate the transcriptome signatures related to the early development of the giant mussel C. chorus.
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Bivalves , Copépodes , Doenças dos Peixes , RNA Longo não Codificante , Salmo salar , Animais , Bivalves/genética , Copépodes/genética , Perfilação da Expressão Gênica , Salmo salar/genética , Salmão/genética , TranscriptomaRESUMO
The activity of marine microorganisms depends on community composition, yet, in some oceans, less is known about the environmental and ecological processes that structure their distribution. The objective of this study was to test the effect of geographical distance and environmental parameters on prokaryotic community structure in the Southern Ocean (SO). We described the total (16S rRNA gene) and the active fraction (16S rRNA-based) of surface microbial communities over a ~6,500 km longitudinal transect in the SO. We found that the community composition of the total fraction was different from the active fraction across the zones investigated. In addition, higher α-diversity and stronger species turnover were displayed in the active community compared to the total community. Oceanospirillales, Alteromonadales, Rhodobacterales, and Flavobacteriales dominated the composition of the bacterioplankton communities; however, there were marked differences at the order level. Temperature, salinity, silicic acid, particulate organic nitrogen, and particulate organic carbon correlated with the composition of bacterioplankton communities. A strong distance-decay pattern between closer and distant communities was observed. We hypothesize that it was related to the different oceanic fronts present in the Antarctic Circumpolar Current. Our findings contribute to a better understanding of the complex arrangement that shapes the structure of bacterioplankton communities in the SO.
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The water-sediment partitioning of flumequine and florfenicol, two antibiotics used in salmon aquaculture is a critical driver of their fate and environmental impact. Batch experiments, were carried out using pure water or seawater, with or without sediment, and at summer and winter temperatures of Chilean fjords. Log Kd (partition between water and sediment) of florfenicol in seawater varied from 0.62 ± 0.69 to 0.67 ± 0.13, and Log KOC (partition between water and organic fraction of sediment) from 2.15± 0.29 to 2.19 ± 0.13. Difference between KOC and the octanol-water partition constant (KOW) showed that for florfenicol, adsorption onto the surface of particles was more significant than the absorption driven by hydrophobicity whilst hydrophobic absorption was a major driver of flumequine sorption. Flumequine Log Kd (0.92 ± 0.25 to 1.36 ± 0.10) and Log KOC (from 2.44 ± 0.25 to 2.89 ± 0.10) demonstrated its greater affinity than florfenicol to particles and potential accumulation into marine sediments.
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Salmão , Água , Animais , Antibacterianos , Aquicultura , Chile , Fluoroquinolonas , Sedimentos Geológicos/química , Tianfenicol/análogos & derivados , Água/químicaRESUMO
BACKGROUND: Negative beliefs about vaccines can threaten herd immunity and pandemic control. Although beliefs about vaccines influence vaccination intention, there are no valid instruments that evaluate this in the Latin American population. AIM: To evaluate the psychometric properties of two scales that measure negative beliefs towards vaccines in general and against SARS-CoV-2 and provide evidence of their association with vaccination intention (convergent validity) in a Chilean sample. MATERIAL AND METHODS: Two studies were carried out. The first included 263 people who answered the beliefs towards vaccines in general scale (CV-G) and the beliefs towards the SARS-CoV-2 vaccine scale (CV-COVID). Exploratory factor analyses were conducted. In the second study, 601 people answered the same scales. Confirmatory factor analyses and structural equation modeling were performed to provide evidence of validity. RESULTS: Both scales had an unifactorial structure and excellent reliability and showed associations with the intention of vaccination against SARS-CoV-2, providing evidence of convergent validity. CONCLUSIONS: The scales evaluated here are reliable and valid measures that showed associations with vaccination intention in the Chilean population.
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COVID-19 , Vacinas , Humanos , Vacinas contra COVID-19 , Psicometria , Reprodutibilidade dos Testes , COVID-19/prevenção & controle , SARS-CoV-2 , Vacinação , IntençãoRESUMO
BACKGROUND: Negative beliefs about vaccines can threaten herd immunity and pandemic control. Although beliefs about vaccines influence vaccination intention, there are no valid instruments that evaluate this in the Latin American population. AIM: To evaluate the psychometric properties of two scales that measure negative beliefs towards vaccines in general and against SARS-CoV-2 and provide evidence of their association with vaccination intention (convergent validity) in a Chilean sample. MATERIAL AND METHODS: Two studies were carried out. The first included 263 people who answered the beliefs towards vaccines in general scale (CV-G) and the beliefs towards the SARS-CoV-2 vaccine scale (CV-COVID). Exploratory factor analyses were conducted. In the second study, 601 people answered the same scales. Confirmatory factor analyses and structural equation modeling were performed to provide evidence of validity. RESULTS: Both scales had an unifactorial structure and excellent reliability and showed associations with the intention of vaccination against SARS-CoV-2, providing evidence of convergent validity. CONCLUSIONS: The scales evaluated here are reliable and valid measures that showed associations with vaccination intention in the Chilean population.
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COVID-19 , Vacinas , Humanos , Vacinas contra COVID-19 , Psicometria , Reprodutibilidade dos Testes , COVID-19/prevenção & controle , SARS-CoV-2 , Vacinação , IntençãoRESUMO
Microorganisms play a crucial role in biogeochemical processes affecting the primary production and biogeochemical cycles of the ocean. In subpolar areas, the increment of the water temperature induced by climate change could lead to changes in the structure and activity of planktonic microbial communities. To understand how the structure of the microbial community in Chilean Patagonian fjords could be affected by climate change, we analyzed the composition of the prokaryotic community (bacteria-archaea) in two fjords (Pia and Yendegaia) with contrasting morphological and hydrological features. We targeted both the standing stock (16S rRNA genes) and the active fraction (16S rRNA transcripts) of the microbial communities during two consecutive austral winters. Our results showed that in both fjords, the active community had higher diversity and stronger biogeographic patterns when compared to the standing stock. Members of the Alpha-, Gamma-, and Deltaproteobacteria followed by archaea from the Marine Group I (Thaumarchaeota) dominated the active communities in both fjords. However, in Pia fjord, which has a marine-terminating glacier, the composition of the microbial community was directly influenced by the freshwater discharges from the adjacent glacier, and indirectly by a possible upwelling phenomenon that could bring deep sea bacteria such as SAR202 to the surface layer. In turn, in the Yendegaia, which has a land-terminating glacier, microbial communities were more similar to the ones described in oceanic waters. Furthermore, in Yendegaia fjord, inter-annual differences in the taxonomic composition and diversity of the microbial community were observed. In conclusion, Yendegaia fjord, without glacier calving, represents a fjord type that will likely be more common under future climate scenarios. Our results showing distinct Yendegaia communities, with for example more potential nitrogen-fixing microorganisms (Planctomycetes), indicate that as a result of climate change, changing planktonic communities could potentially impact biogeochemical processes and nutrient sources in subantarctic fjords.
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The COVID-19 pandemic has had a significant impact on populations at an economic, health, and on an interpersonal level, it is still unclear how it has affected health-risk behaviors, such as comfort food consumption over time. This study longitudinally examines the effect of the perceived impact of COVID-19 on comfort food consumption and whether this effect is mediated by emotional distress. A convenience sample of 1048 students and university staff (academic and non-academic) from two universities completed monthly online surveys during the COVID-19 pandemic across six waves (W; W1 to W6). Participants reported their perceived impact of COVID-19 (economic, interpersonal, and health), comfort food consumption, and emotional distress (DASS-21). Using structural equation models, we found an indirect longitudinal effect of the perceived impact of COVID-19 (W1) on comfort food consumption (W3 to W6) through increased emotional distress (W2). The perceived negative impact of COVID-19 on comfort food consumption was fully mediated by the emotional distress during the first waves (W3 and W4), ending in a partial mediation in the last waves (W5 and W6). These findings contribute to disentangling the mechanisms by which the perceived impact of COVID-19 affects comfort food consumption over time, and highlight the role of emotional distress. Future interventions should address comfort food consumption by focusing on handling emotional distress during a crisis.
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COVID-19/psicologia , Dieta/psicologia , Emoções , Comportamento Alimentar/psicologia , Pandemias , Angústia Psicológica , Estresse Psicológico/etiologia , Adolescente , Adulto , Idoso , Docentes , Feminino , Comportamentos Relacionados com a Saúde , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Estudos Longitudinais , Masculino , Pessoa de Meia-Idade , Percepção , SARS-CoV-2 , Estresse Psicológico/dietoterapia , Estudantes , Inquéritos e Questionários , Universidades , Adulto JovemRESUMO
CONTEXT: The clinical and laboratory features of dominant acute hepatic porphyrias (AHPs) in prepubertal children and adolescents have not been well established. OBJECTIVE: To evaluate clinical and laboratory features of AHPs in prepubertal children and adolescents compared to adults. DATA SOURCES: OVID (Embase Classic+Embase and MEDLINE), Scopus, and Google Scholar. STUDY SELECTION: Studies describing symptomatic children or adolescents (<18 years old) with increased urinary porphobilinogen were included. DATA EXTRACTION: Two reviewers independently extracted the data, with a third reviewer arbitrating discrepancies. RESULTS: 100 studies were included describing 112 patients (26 prepubertal children and 86 adolescents). Differences were found between prepubertal children and adolescents regarding sex distribution (female-to-male ratio: 1:2 vs. 4:1), clinical manifestations, and concomitant clinical manifestations. LIMITATIONS: There was variation in the methods used to diagnose porphyria attacks across studies, and some elements of the quality of individual studies were unclear. CONCLUSIONS: Prepubertal children with AHPs and porphyria attacks presented with distinct demographic and clinical characteristics from adolescents and adults. Nearly two-thirds of the affected children were males, and about half had a concomitant medical condition that can constitutively upregulate hepatic δ-aminolevulinic acid synthase-1. Adolescents were comparable to adults in almost all respects.
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Sintase do Porfobilinogênio/deficiência , Porfirias Hepáticas/diagnóstico , Porfirias Hepáticas/fisiopatologia , Adolescente , Adulto , Criança , Feminino , Humanos , Fígado/patologia , Masculino , Distribuição por SexoRESUMO
Chile is a major global producer of farmed salmon in the fjords of Patagonia, and therefore a major consumer of antibiotics. We tested whether the antibiotics florfenicol and flumequine persisted in the large Puyuhuapi Fjord after the six months following mandatory concerted treatment by all salmon farms present in the fjord. Antibiotics were detected in 26% of analyzed samples, but only within the particulate phase, with concentrations of florfenicol of up to 23.1 ng L-1, where detected. Flumequine was present in one sample at trace concentration, and neither antibiotic was detected in the dissolved phase nor in surface sediments. A fugacity-based model predicted that flumequine should theoretically remain in surface sediments at the sub-Minimal Inhibiting Concentrations (sub-MIC) previously shown to promote selection for antibiotic resistance in bacteria. Our observations suggest that surface sediments might act as a reservoir for antibiotic resistomes of bacteria, and that bacteria bearing antibiotic resistance genes could eventually become a risk for human health through the consumption of marine products.