[Non-specific vaginitis and topical treatment. Comparison of flunoxaprofen and benzydamine]. / Vaginiti aspecifiche e trattamento topico. Confronto tra flunoxaprofene e benzidamina.

The efficacy and tolerability of a new NSAID-flunoxaprofen-have been evaluated in patients suffering from non specific vaginitis, by topical application for 20 days (vaginal washings with water solution of the preparation). The activity of flunoxaprofen has been compared with that of benzidamine with regard to normalization of bacterial vaginal flora, taking into consideration the increase of Döderlein bacillus. A remarkable significant improvement of all the symptoms has been observed in the group of patients treated with flunoxaprofen with respect to that receiving benzidamine; moreover 57.9% of the subjects treated with flunoxaprofen showed a significant increase of Döderlein bacillus while in the benzidamine group the percentage reached a value of 11.8%. Flunoxaprofen may be considered a useful and active tool for the topical treatment of non specific vaginal diseases.

[Cervical conization in the diagnosis and treatment of cervical epithelial neoplasms]. / La conizzazione cervicale nella diagnosi e nel trattamento della CIN.

Thirty-seven patients who underwent cone biopsy for cervical intraepithelial neoplasia (CIN) of varying gravity have been considered. The follow-up points to the therapeutic as well as diagnostic value of this intervention (92% success). Analysis of the responses provided by colpocytology in comparison with those provided by biopsy, evidences the poor diagnostic reliability of the pap-test with respect to intraepithelial lesions of the uterine cervix (under-estimated in 51% of cases compared to biopsy). Operation did not substantially modify patients' reproductive capability (5 pregnancies of which 3 developing, during the control period) an extremely important factor in view of the young age of patients (average 31 years).