RESUMO
The aim of this study was to determine how different types of P. vivax affect clinical symptoms and parasitaemia clearance. Blood was collected from individuals from Pará State, Brazil. The patients were treated as chloroquine plus primaquine. P. vivax were typed daily till D7 and again on D30. Now we can confirm a previously reported correlation between P. vivax genotype and response to chloroquine. Clinical symptoms do not allow for objective identification of different P. vivax types in the Brazilian Amazon, since the VK247 and P. vivax-like have only been detected in mixed infections.
Assuntos
Antimaláricos/uso terapêutico , Cloroquina/uso terapêutico , Malária Vivax/parasitologia , Parasitemia/tratamento farmacológico , Plasmodium vivax/genética , Primaquina/uso terapêutico , Animais , Brasil , Variação Genética , Genótipo , Humanos , Malária Vivax/tratamento farmacológico , Plasmodium vivax/efeitos dos fármacosRESUMO
The study was carried out to evaluate the diagnostic performance of the ICT malaria Pf/Pv test for vivax malaria diagnosis in Bel m, Amazon region, Brazil. The results of blood malaria parasites examination using an immunochromatography test were compared with thick blood film (TBF) examination. It was also evaluated the performance of this test storaged at three different temperatures (25 degree C, 30 degree C, and 37 degree C) for 24 hours before use. Overall sensitivity of ICT Pf/Pv was 61.8% with a specificity of 100%, positive and negative predictive value of 100% and 71.8%, respectively and accuracy of 80.6%. The test sensitivity was independent of the parasite density. This test needs to be further reviewed in order to have better performance for P. vivax malaria diagnosis.
Assuntos
Malária Vivax/diagnóstico , Plasmodium vivax/imunologia , Animais , Brasil , Cromatografia/métodos , Humanos , Testes Imunológicos , Malária Vivax/imunologia , Malária Vivax/parasitologia , Plasmodium vivax/isolamento & purificação , Valor Preditivo dos Testes , Sensibilidade e EspecificidadeRESUMO
The aim of this study was to determine how different types of P. vivax affect clinical symptoms and parasitaemia clearance. Blood was collected from individuals from Pará State, Brazil. The patients were treated as chloroquine plus primaquine. P. vivax were typed daily till D7 and again on D30. Now we can confirm a previously reported correlation between P. vivax genotype and response to chloroquine. Clinical symptoms do not allow for objective identification of different P. vivax types in the Brazilian Amazon, since the VK247 and P. vivax-like have only been detected in mixed infections
Assuntos
Animais , Humanos , Antimaláricos , Cloroquina , Parasitemia , Plasmodium vivax , Primaquina , Brasil , Variação Genética , Genótipo , ParasitemiaRESUMO
Avaliaçäo do teste ICT malaria Pf/PvTM para o diagnóstico da malária por P. vivax em Belém, Estado do Pará. Foram comparados os resultados do teste imunocromatográfico com a gota espessa (GE) e avaliados o comportamento desse teste, estocado a três temperaturas distintas (250C/ 300C/ 370C), 24 horas antes de seu uso. A sensibilidade do ICT malaria Pf/PvTM foi de 61,8 por cento com especificidade de 100por cento, valores preditivo positivo e negativo de 100 por cento e 71,8 por cento, respectivamente, e acurácia de 80,67por cento. A sensibilidade desse teste foi independente da densidade parasitária. Este teste necessita de reavaliaçäo para melhorar o seu comportamento no diagnóstico da malária por P. vivax