Assuntos
Dermatite , Líquen Plano , Humanos , Alopecia/etiologia , Linfócitos , Fator de Transcrição STAT3RESUMO
Low-grade fibromyxoid sarcoma (LGFMS) is a histopathologically deceptive soft tissue neoplasm with bland cytology, which is typically encountered in deep soft tissue of adults. We report two cases of superficial LGFMS in young patients (16 and 21 years old, respectively), which were difficult to diagnose on histopathologic and clinical findings alone. LGFMS commonly mimics benign neoplasms such as cellular neurothekeoma, fibromatosis, neurofibroma, and perineurioma. Malignancies included in the differential diagnosis are soft tissue neoplasms such as dermatofibrosarcoma protuberans and myxofibrosarcoma. A high degree of reported variation in pattern and cellularity among LGFMS further complicates the diagnosis. Careful examination and appropriate immunohistochemistry panels including MUC4 are essential for narrowing the differential diagnosis. Molecular studies for possible FUS translocation can confirm the diagnosis of LGFMS. Sufficient sampling and workup of these lesions are critical, especially in younger patients. Young age and superficial presentation can easily sway dermatopathologists/dermatologists toward an incorrect diagnosis of benignancy.
Assuntos
Fibroma , Fibrossarcoma , Neoplasias de Bainha Neural , Neoplasias de Tecidos Moles , Adolescente , Adulto , Fibroma/diagnóstico , Fibroma/patologia , Fibrossarcoma/diagnóstico , Fibrossarcoma/patologia , Humanos , Imuno-Histoquímica , Neoplasias de Tecidos Moles/patologia , Adulto JovemAssuntos
Alopecia , Dermatite , Alopecia/etiologia , Alopecia/patologia , Cicatriz/etiologia , Cicatriz/patologia , Dermatite/patologia , Cabelo/patologia , HumanosRESUMO
We describe a patient with leukemia undergoing chemotherapy who developed painful purpuric nodules of the digits. These findings were concerning for endocarditis (clinically) and angiokeratomas on gross histology. After extensive evaluation, we report the development of painful purpuric nodules as a likely side effect of the patient's therapeutic regimen (hydroxyurea, danorubicin, cytarabine, and methotrexate).
Assuntos
Angioceratoma/induzido quimicamente , Protocolos de Quimioterapia Combinada Antineoplásica/efeitos adversos , Dermatoses da Mão/induzido quimicamente , Leucemia/tratamento farmacológico , Púrpura/induzido quimicamente , Neoplasias Cutâneas/induzido quimicamente , Angioceratoma/diagnóstico , Citarabina/administração & dosagem , Daunorrubicina/administração & dosagem , Diagnóstico Diferencial , Feminino , Dermatoses da Mão/diagnóstico , Humanos , Hidroxiureia/administração & dosagem , Metotrexato/administração & dosagem , Pessoa de Meia-Idade , Púrpura/diagnóstico , Púrpura/patologia , Neoplasias Cutâneas/diagnósticoRESUMO
Nail unit pathology is indispensable to reach an accurate diagnosis of nail tumors as well as inflammatory disorders. This review article provides an update from the most recently published studies on the pathology and management of nail unit tumors and inflammatory disorders. Recent findings of nail clipping histopathology are described first, followed by discussing recent data on the diagnosis and surgical management of several types of nail unit tumors, ending with discussing the recent discoveries in selected nail unit inflammatory disorders.
Assuntos
Doenças da Unha , Neoplasias , Biópsia , Humanos , Doenças da Unha/diagnóstico , UnhasRESUMO
Indeterminate cell histiocytosis (ICH) is a rare proliferative disorder of histiocytes, which display morphologic and immunophenotypic characteristics of both Langerhans cell histiocytosis (LCH) and non-Langerhans cell histiocytosis (NLCH). We describe an unusual clinical presentation of ICH mimicking rosacea and provide a relevant review of the literature.
Assuntos
Doença de Crohn/complicações , Genitália/patologia , Linfedema/patologia , Pele/patologia , Verrugas/patologia , Administração Tópica , Adolescente , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Biópsia/métodos , Quimioterapia Combinada , Feminino , Humanos , Imuno-Histoquímica/métodos , Imunossupressores/administração & dosagem , Imunossupressores/uso terapêutico , Injeções Intralesionais , Linfedema/complicações , Dor/diagnóstico , Dor/etiologia , Prurido/diagnóstico , Prurido/etiologia , Sirolimo/administração & dosagem , Sirolimo/uso terapêutico , Pele/metabolismo , Resultado do Tratamento , Triancinolona/administração & dosagem , Triancinolona/uso terapêuticoAssuntos
Alcaptonúria/patologia , Ocronose/patologia , Pele/patologia , Feminino , Humanos , Pessoa de Meia-IdadeAssuntos
Mixoma/diagnóstico , Nevo/diagnóstico , Dermatopatias/patologia , Neoplasias Cutâneas/patologia , Adolescente , Antígenos CD34/metabolismo , Conscientização , Biópsia , Dermatologistas , Diagnóstico Diferencial , Erros de Diagnóstico , Humanos , Masculino , Mucinose Folicular/patologia , Nevo/cirurgia , Dermatopatias/congênitoAssuntos
Alopecia/patologia , Células Epiteliais/patologia , Folículo Piloso/patologia , Queratina-15/metabolismo , Células-Tronco/patologia , Cicatriz/diagnóstico , Cicatriz/patologia , Células Epiteliais/ultraestrutura , Fibrose/diagnóstico , Fibrose/patologia , Folículo Piloso/ultraestrutura , Humanos , Líquen Plano/imunologia , Líquen Plano/patologia , Lúpus Eritematoso Discoide/imunologia , Lúpus Eritematoso Discoide/patologia , Microscopia de Fluorescência/métodos , Células-Tronco/citologia , Células-Tronco/imunologiaRESUMO
The Shapiro xanthogranuloma is a histopathologic form of xanthogranuloma that shows closely packed monomorphous cells, which can extend into the subcutaneous fat; it usually lacks routine diagnostic features of xanthogranuloma. Herein we describe two cases of Shapiro xanthogranuloma occurring in a neonate and in an infant, which were initially thought to be hematologic malignancies. One patient's presentation as a "blueberry muffin baby" added to the diagnostic confusion. Pediatric dermatologists, dermatologists, and dermatopathologists need to be aware of the Shapiro xanthogranuloma and its clinicopathologic features to avoid misdiagnosis of a hematopoietic malignancy in neonates and infants.
Assuntos
Granuloma/diagnóstico , Neoplasias Hematológicas/diagnóstico , Leucemia/diagnóstico , Dermatopatias/patologia , Xantogranuloma Juvenil/diagnóstico , Xantomatose/diagnóstico , Conscientização , Dermatologistas , Erros de Diagnóstico , Feminino , Granuloma/patologia , Neoplasias Hematológicas/patologia , Humanos , Lactente , Recém-Nascido , Leucemia/patologia , Masculino , Neurofibromatoses/complicações , Síndrome de Noonan/complicações , Patologistas , Xantogranuloma Juvenil/patologia , Xantomatose/patologiaRESUMO
Schwannoma is a tumor of schwann cell proliferation which presents as a solitary, soft, skin-colored dermal or subcutaneous papulo-nodule most commonly on the flexor part of extremities and head and neck areas. Here, we report a case of nail unit schwannoma, which is a rare tumor of the nail apparatus with only 4 other prior reports in the literature. This case illustrates the importance of including subungual schwannoma in the clinical differential diagnosis of subungual soft tissue tumors. We include a literature review which catalogs and summarizes the current knowledge regarding this unusual nail unit neoplasm.