[Adverse cutaneous reaction to celecoxib: 6 cases]. / Toxidermies au célécoxib: 6 cas.

INTRODUCTION: Our objective was to characterize adverse cutaneous reactions to celecoxib, a new non steroidal anti-inflammatory drug. PATIENTS AND METHODS: A retrospective study of 6 consecutive patients. RESULTS: The average delay before the onset of the reaction was 10.2 days for patients taking the medication for the first time and 48 hours for one patient taking the drug for the second time. Two patients had fever. Patients presented with an exanthema and in most cases an edema of the face. Buccal mucosa was involved in two patients, and one patient had minimal blister lesions. In five of the six patients, minor and transitory biological abnormalities were found. The intrinsic imputability of the celecoxib was I3 (C3S2) in all the cases. DISCUSSION: Our cases are similar to those reported by the French drug regulatory agency (Pharmacovigilance). Usually the adverse cutaneous reactions were not too severe, with maculo-papulo exanthema and edema of the face. The reactions due to celecoxib are more frequent than those due to other non steroidal anti-inflammatory drugs (7.5% versus 4.1%), but severe cases are rarely reported. Besides, an allergic history to sulphonamide contraindicates celecoxib. However celecoxib does not have the aromatic amine common to antibacterial sulphonamides, and there is no proof of cross reactions between these two families. Furthermore, this amine is usually associated with drug reaction severity, which could explain why severe cases due to celecoxib are rare.

Spectral and duration properties of front vowels as cues to final stop-consonant voicing.

The perception of voicing in final velar stop consonants was investigated by systematically varying vowel duration, change in offset frequency of the final first formant (F1) transition, and rate of frequency change in the final F1 transition for several vowel contexts. Consonant-vowel-consonant (CVC) continua were synthesized for each of three vowels, [i,I,ae], which represent a range of relatively low to relatively high-F1 steady-state values. Subjects responded to the stimuli under both an open- and closed-response condition. Results of the study show that both vowel duration and F1 offset properties influence perception of final consonant voicing, with the salience of the F1 offset property higher for vowels with high-F1 steady-state frequencies than low-F1 steady-state frequencies, and the opposite occurring for the vowel duration property. When F1 onset and offset frequencies were controlled, rate of the F1 transition change had inconsistent and minimal effects on perception of final consonant voicing. Thus the findings suggest that it is the termination value of the F1 offset transition rather than rate and/or duration of frequency change, which cues voicing in final velar stop consonants during the transition period preceding closure.