Elucidating the Visual Snow Spectrum: A Latent Class Analysis Study.

Objective: People with visual snow syndrome (VSS) experience a range of perceptual phenomena, in addition to visual snow (VS; flickering pinpricks of light throughout the visual field). We investigated the patterns of perceptual phenomena associated with VSS in a large sample of people without prior knowledge of VSS or its associated symptoms. Methods and Measures. Two thousand participants completed a screening questionnaire assessing the frequency and severity of perceptual phenomena associated with VSS. We used latent class analysis (LCA), a clustering technique which identifies qualitatively different subgroups within a given population, to investigate whether the presence (or absence) of VS impacted class structure. Results: Of 1,846 participants included for analysis, 41.92% experienced VS some of the time, including 4.49% who had VSS without prior knowledge. The mean number of perceptual phenomena experienced was 2.03. Optimal four-class LCA solutions did not substantially differ whether VS was included in the model; instead, classes differed in the frequency and total number of symptoms experienced. Discussion. Our results suggest that the perceptual phenomena associated with VSS are likely to be common in the general population and do not necessarily indicate an underlying pathology. We also showed that visual snow itself does not explain the presence of other perceptual phenomena.

Perceived severity of Visual Snow Syndrome is associated with visual allodynia.

OBJECTIVE: To investigate whether sensory sensitivity is associated with the perceived severity of Visual Snow Syndrome (VSS) symptoms. BACKGROUND: Visual Snow (VS) is a perceptual anomaly which manifests as flashing pinpricks of light throughout the visual field. VSS has an estimated population prevalence of 2.2% and is thought to be at least moderately debilitating for all who experience it. However, some people who meet the criteria for VSS have no awareness of it. This may be because they have lower sensory sensitivity, allowing them to ignore their visual phenomena. METHOD: Our study used a cross-sectional design. We recruited two distinct samples of people with VSS: a sample of people with confirmed VSS; and a sample of people who met the criteria for the condition but had no prior knowledge of it (latent VSS). The latter group was recruited and screened for symptoms via an online crowd-sourcing platform. In total, 100 participants with VSS (49 with confirmed VSS, 51 with latent VSS) completed the Visual Snow Handicap Index and three measures of sensory hypersensitivity. RESULTS: The 100 participants (52 female, 47 male, 1 non-binary) had a mean age of 35.1 years (SD = 12.2). Leiden Visual Sensitivity Scale scores were associated with both the perceived severity of VSS, ß = 0.35, p = 0.003, and the number of VSS symptoms endorsed, ß = 0.45, p < 0.001. On average, participants with VSS experienced elevated sensory hypersensitivity across all measures. Furthermore, longer duration of VSS was associated with lower perceived severity, F(1, 98) = 11.37, p = 0.001, R2  = 0.103. CONCLUSIONS: Our results suggest that sensory hypersensitivity may be prevalent in people with VSS and indicate that visual allodynia is associated with increased severity of VSS. Additionally, our findings indicate that inclusion of cases of latent VSS in future research may be important for researchers to develop a more complete understanding of the perceptual experiences of people with VSS.

Biomechanical and cognitive interactions during Visuo Motor Targeting Task.

BACKGROUND: Biomechanical analyses primarily focus on physical aspects of human movement; however, it is not understood how walking is affected while simultaneously performing a demanding cognitive task - a form of Cognitive-Motor Interference (CMI). CMI occurs when performance of a primary task (e.g. walking) is affected following the introduction of a cognitive task (e.g. visual search). RESEARCH QUESTION: Would Visuo Motor Targeting Task (VMTT) impair visual search performance and reduce the margin of stability (MoS) at higher gait speeds? METHODS: A protocol was developed to investigate responses of the neuromuscular system while performing a complex visual search task. The Computer Assisted Rehabilitation ENvironment (CAREN, Motekforce Link, Netherlands) system was used for the experimental design. Twenty male participants (Age = 24.2 ± 2.5yrs, Weight = 70.3 ± 10.6 kg, Height = 178.0 ± 9.1 cm) located and pointed towards targets in complex scenes while walking at different gait speeds (0.55, 1.11 and 1.67 m/s.) or while stationary. The cost of visual search during a Visuo Motor Targeting Task (VMTT) was based on the pointing accuracy during the visual search task. RESULTS: A two-way repeated measure ANOVA showed that MoS in the ML direction significantly improved with increased gait speed and during the visual search task. There was also a significant interaction with MoS improvement being greater during the visual search task at high gait speeds. MoS in the AP was only affected by gait speed. Visual performance and cost of visual search were enhanced during walking versus standing up to 25 %. SIGNIFICANCE: This study investigated CMI at different gait speeds, which may have implications in postural control, falls and other neurological disorders.

Spatial complexity facilitates ordinal mapping with a novel symbol set.

The representation of number symbols is assumed to be unique, and not shared with other ordinal sequences. However, little research has examined if this is the case, or whether properties of symbols (such as spatial complexity) affect ordinal learning. Two studies were conducted to investigate if the property of spatial complexity affects learning ordinal sequences. In Study 1, 46 adults made a series of judgements about two novel symbol sets (Gibson and Sunúz). The goal was to find a novel symbol set that could be ordered by spatial complexity. In Study 2, 84 adults learned to order nine novel symbols (Sunúz) with a paired comparison task, judging which symbol was 'larger' (whereby the larger symbol became physically larger as feedback), and were then asked to rank the symbols. Participants were assigned to either a condition where there was a relationship between spatial complexity and symbol order, or a condition where there was a random relationship. Of interest was whether learning an ordered list of symbols would be facilitated by the spatial complexity of the novel symbols. Findings suggest spatial complexity affected learning ability, and that pairing spatial complexity with relational information can facilitate learning ordinal sequences. This suggests that the implicit cognitive representation of number may be a more general feature of ordinal lists, and not exclusive to number per se.

Enumeration strategy differences revealed by saccade-terminated eye tracking.

Brain regions involved in saccadic eye movements partially overlap with a frontoparietal network implicated in encoding numerosities. Eye movement patterns may plausibly reflect strategic scanning behaviours to resolve the open-ended task of efficiently enumerating visual arrays. If so, these patterns may help explain individual differences in enumeration acuity in terms of well-understood visual attention mechanisms. Most enumeration eye-tracking paradigms, however, do not allow for direct manipulation of eye movement behaviours to test these claims. In the current study we terminated trials after a specified number of saccades to systematically probe the time course of enumeration strategies. Fifteen adults (11 naïve, 4 informed) enumerated random dot arrays under three conditions: (1) a novel saccade-terminated design where arrays were visible until one, two or four saccades had occurred; (2) a duration-terminated design where arrays were shown for 250, 500 or 1000 ms; and (3) a response-terminated design where arrays were visible until a response. Participants gave more accurate responses when enumerating saccade-terminated trials despite taking a similar time as in the duration-terminated trials. When participants were informed how trials would terminate, their saccade onset latencies shifted to match task demands. Rotating saccade vectors to align with salient image locations accounted for variability in the orientation of saccade trajectories. These findings (1) show a combination of stimulus-derived visual processing and task-based strategic demands account for enumeration eye movements patterns, (2) validate a novel saccade-contingent trial termination procedure for studying sequences of enumeration eye movements, and (3) highlight the need to include analyses of spatial and temporal eye movement patterns into models of visual enumeration strategies.

Rivalry Onset in and around the Fovea: The Role of Visual Field Location and Eye Dominance on Perceptual Dominance Bias.

When dissimilar images are presented to each eye, the images will alternate every few seconds in a phenomenon known as binocular rivalry. Recent research has found evidence of a bias towards one image at the initial 'onset' period of rivalry that varies across the peripheral visual field. To determine the role that visual field location plays in and around the fovea at onset, trained observers were presented small orthogonal achromatic grating patches at various locations across the central 3° of visual space for 1-s and 60-s intervals. Results reveal stronger bias at onset than during continuous rivalry, and evidence of temporal hemifield dominance across observers, however, the nature of the hemifield effects differed between individuals and interacted with overall eye dominance. Despite using small grating patches, a high proportion of mixed percept was still reported, with more mixed percept at onset along the vertical midline, in general, and in increasing proportions with eccentricity in the lateral hemifields. Results show that even within the foveal range, onset rivalry bias varies across visual space, and differs in degree and sensitivity to biases in average dominance over continuous viewing.

The Importance of Ordinal Information in Interpreting Number/Letter Line Data.

The degree to which the ability to mark the location of numbers on a number-to-position (NP) task reflects a mental number line (MNL) representation, or a representation that supports ordered lists more generally, is yet to be resolved. Some argue that findings from linear equation modeling, often used to characterize NP task judgments, support the MNL hypothesis. Others claim that NP task judgments reflect strategic processes; while others suggest the MNL proposition could be extended to include ordered list processing more generally. Insofar as the latter two claims are supported, it would suggest a more nuanced account of the MNL hypothesis is required. To investigate these claims, 84 participants completed a NP and an alphabet-to-position task in which they marked the position of numbers/letters on a horizontal line. Of interest was whether: (1) similar judgment deviations from linearity occurred for number/letter stimuli; (2) left-to-right or right-to-left lines similarly, affected number/letter judgments; and (3) response times (RTs) differed as a function of number/letter stimuli and/or reverse/standard lines. While RTs were slower marking letter stimuli compared to number stimuli, they did not differ in the standard compared to the reverse number/letter lines. Furthermore, similar patterns of non-linear RTs were found marking stimuli on the number/letter lines, suggesting that similar strategic processes were at play. These findings suggest that a general mental representation may underlie ordered list processing and that a linear mental representation is not a unique feature of number per se. This is consistent with the hypothesis that number is supported by a representation that lends itself to processing ordered sequences in general.

Implications of Change/Stability Patterns in Children's Non-symbolic and Symbolic Magnitude Judgment Abilities Over One Year: A Latent Transition Analysis.

Non-symbolic magnitude abilities are often claimed to support the acquisition of symbolic magnitude abilities, which, in turn, are claimed to support emerging math abilities. However, not all studies find links between non-symbolic and symbolic magnitude abilities, or between them and math ability. To investigate possible reasons for these different findings, recent research has analyzed differences in non-symbolic/symbolic magnitude abilities using latent class modeling and has identified four different magnitude ability profiles residing within the general magnitude ability distribution that were differentially related to cognitive and math abilities. These findings may help explain the different patterns of findings observed in previous research. To further investigate this possibility, we (1) attempted to replicate earlier findings, (2) determine whether magnitude ability profiles remained stable or changed over 1 year; and (3) assessed the degree to which stability/change in profiles were related to cognitive and math abilities. We used latent transition analysis to investigate stability/changes in non-symbolic and symbolic magnitude abilities of 109 5- to 6-year olds twice in 1 year. At Time 1 and 2, non-symbolic and symbolic magnitude abilities, number transcoding and single-digit addition abilities were assessed. Visuospatial working memory (VSWM), naming numbers, non-verbal IQ, basic RT was also assessed at Time 1. Analysis showed stability in one profile and changes in the three others over 1 year. VSWM and naming numbers predicted profile membership at Time 1 and 2, and profile membership predicted math abilities at both time points. The findings confirm the existence of four different non-symbolic-symbolic magnitude ability profiles; we suggest the changes over time in them potentially reflect deficit, delay, and normal math developmental pathways.

Taking a(c)count of eye movements: Multiple mechanisms underlie fixations during enumeration.

We habitually move our eyes when we enumerate sets of objects. It remains unclear whether saccades are directed for numerosity processing as distinct from object-oriented visual processing (e.g., object saliency, scanning heuristics). Here we investigated the extent to which enumeration eye movements are contingent upon the location of objects in an array, and whether fixation patterns vary with enumeration demands. Twenty adults enumerated random dot arrays twice: first to report the set cardinality and second to judge the perceived number of subsets. We manipulated the spatial location of dots by presenting arrays at 0°, 90°, 180°, and 270° orientations. Participants required a similar time to enumerate the set or the perceived number of subsets in the same array. Fixation patterns were systematically shifted in the direction of array rotation, and distributed across similar locations when the same array was shown on multiple occasions. We modeled fixation patterns and dot saliency using a simple filtering model and show participants judged groups of dots in close proximity (2°-2.5° visual angle) as distinct subsets. Modeling results are consistent with the suggestion that enumeration involves visual grouping mechanisms based on object saliency, and specific enumeration demands affect spatial distribution of fixations. Our findings highlight the importance of set computation, rather than object processing per se, for models of numerosity processing.

No significant effect of transcranial direct current stimulation (tDCS) found on simple motor reaction time comparing 15 different simulation protocols.

BACKGROUND: Research exploring the behavioral impact of transcranial direct current stimulation (tDCS) over M1 has produced homogenous results. The most common explanations to address this homogeneity concerns the differential impact of varied tDCS parameters (such as stimulation intensity or electrode montage). To explore this, we systematically examined the effects of 15 different tDCS protocols on a well-elucidated neurobehavioral system: simple visual motor reaction time (smRT). METHODS: For the initial phase of this study, 150 healthy participants were randomly assigned to one of 5 experimental groups (2mA anodal, 2mA cathodal, 1mA anodal, 1mA cathodal, or sham) across 3 different conditions (orbitofrontal, bilateral, or extracephalic reference electrode location). The active electrode was always placed over M1 and tDCS lasted for 20min. Starting ~5min prior to stimulation and running continuously for ~30min, participants were repeatedly presented with a visual cue centered on a computer monitor and asked to press a response button as quickly as possible at stimulus onset (stimuli number: 100 pre-, 400 during-, and 100-post stimulation - interstimulus interval: 1-3s). Ex-gaussian distribution curves, miss, and error rates were determined for each normalized batch of 100 RTs and compared using a two-way ANOVA. As the largest group differences were seen with 2mA anodal (compared to sham) stimulation using an orbitofrontal montage, an additional 60 healthy participants were recruited to further test for significance in this condition. RESULTS: No significant impact of tDCS was seen on any parameter of smRT distribution, error rate, or miss rate, regardless of polarity, stimulation intensity, electrode montage, or stimulation-to-task relationship. CONCLUSION: Our results suggest that tDCS over M1 might not have a predictable or reliable effect on short duration smRT. Our results raise interesting questions regarding the mechanisms by which tDCS might modulate more complex motor behaviors. Additional research utilizing multiple tDCS protocols as undertaken here will help address and clarify these concerns.

Cognitive factors affecting children's nonsymbolic and symbolic magnitude judgment abilities: A latent profile analysis.

Early math abilities are claimed to be linked to magnitude representation ability. Some claim that nonsymbolic magnitude abilities scaffold the acquisition of symbolic (Arabic number) magnitude abilities and influence math ability. Others claim that symbolic magnitude abilities, and ipso facto math abilities, are independent of nonsymbolic abilities and instead depend on the ability to process number symbols (e.g., 2, 7). Currently, the issue of whether symbolic abilities are or are not related to nonsymbolic abilities, and the cognitive factors associated with nonsymbolic-symbolic relationships, remains unresolved. We suggest that different nonsymbolic-symbolic relationships reside within the general magnitude ability distribution and that different cognitive abilities are likely associated with these different relationships. We further suggest that the different nonsymbolic-symbolic relationships and cognitive abilities in combination differentially predict math abilities. To test these claims, we used latent profile analysis to identify nonsymbolic-symbolic judgment patterns of 124, 5- to 7-year-olds. We also assessed four cognitive factors (visuospatial working memory [VSWM], naming numbers, nonverbal IQ, and basic reaction time [RT]) and two math abilities (number transcoding and single-digit addition abilities). Four nonsymbolic-symbolic ability profiles were identified. Naming numbers, VSWM, and basic RT abilities were differentially associated with the different ability profiles and in combination differentially predicted math abilities. Findings show that different patterns of nonsymbolic-symbolic magnitude abilities can be identified and suggest that an adequate account of math development should specify the inter-relationship between cognitive factors and nonsymbolic-symbolic ability patterns.

Effects of a common transcranial direct current stimulation (tDCS) protocol on motor evoked potentials found to be highly variable within individuals over 9 testing sessions.

Transcranial direct current stimulation (tDCS) uses a weak electric current to modulate neuronal activity. A neurophysiologic outcome measure to demonstrate reliable tDCS modulation at the group level is transcranial magnetic stimulation engendered motor evoked potentials (MEPs). Here, we conduct a study testing the reliability of individual MEP response patterns following a common tDCS protocol. Fourteen participants (7m/7f) each underwent nine randomized sessions of 1 mA, 10 min tDCS (3 anode; 3 cathode; 3 sham) delivered using an M1/orbito-frontal electrode montage (sessions separated by an average of ~5.5 days). Fifteen MEPs were obtained prior to, immediately following and in 5 min intervals for 30 min following tDCS. TMS was delivered at 130 % resting motor threshold using neuronavigation to ensure consistent coil localization. A number of non-experimental variables were collected during each session. At the individual level, considerable variability was seen among different testing sessions. No participant demonstrated an excitatory response ≥20 % to all three anodal sessions, and no participant demonstrated an inhibitory response ≥20 % to all three cathodal sessions. Intra-class correlation revealed poor anodal and cathodal test-retest reliability [anode: ICC(2,1) = 0.062; cathode: ICC(2,1) = 0.055] and moderate sham test-retest reliability [ICC(2,1) = 0.433]. Results also revealed no significant effect of tDCS at the group level. Using this common protocol, we found the effects of tDCS on MEP amplitudes to be highly variable at the individual level. In addition, no significant effects of tDCS on MEP amplitude were found at the group level. Future studies should consider utilizing a more strict experimental protocol to potentially account for intra-individual response variations.

Quantitative Review Finds No Evidence of Cognitive Effects in Healthy Populations From Single-session Transcranial Direct Current Stimulation (tDCS).

BACKGROUND: Over the last 15-years, transcranial direct current stimulation (tDCS), a relatively novel form of neuromodulation, has seen a surge of popularity in both clinical and academic settings. Despite numerous claims suggesting that a single session of tDCS can modulate cognition in healthy adult populations (especially working memory and language production), the paradigms utilized and results reported in the literature are extremely variable. To address this, we conduct the largest quantitative review of the cognitive data to date. METHODS: Single-session tDCS data in healthy adults (18-50) from every cognitive outcome measure reported by at least two different research groups in the literature was collected. Outcome measures were divided into 4 broad categories: executive function, language, memory, and miscellaneous. To account for the paradigmatic variability in the literature, we undertook a three-tier analysis system; each with less-stringent inclusion criteria than the prior. Standard mean difference values with 95% CIs were generated for included studies and pooled for each analysis. RESULTS: Of the 59 analyses conducted, tDCS was found to not have a significant effect on any - regardless of inclusion laxity. This includes no effect on any working memory outcome or language production task. CONCLUSION: Our quantitative review does not support the idea that tDCS generates a reliable effect on cognition in healthy adults. Reasons for and limitations of this finding are discussed. This work raises important questions regarding the efficacy of tDCS, state-dependency effects, and future directions for this tool in cognitive research.

Evidence that transcranial direct current stimulation (tDCS) generates little-to-no reliable neurophysiologic effect beyond MEP amplitude modulation in healthy human subjects: A systematic review.

BACKGROUND: Transcranial direct current stimulation (tDCS) is a form of neuromodulation that is increasingly being utilized to examine and modify a number of cognitive and behavioral measures. The theoretical mechanisms by which tDCS generates these changes are predicated upon a rather large neurophysiological literature. However, a robust systematic review of this neurophysiological data has not yet been undertaken. METHODS: tDCS data in healthy adults (18-50) from every neurophysiological outcome measure reported by at least two different research groups in the literature was collected. When possible, data was pooled and quantitatively analyzed to assess significance. When pooling was not possible, data was qualitatively compared to assess reliability. RESULTS: Of the 30 neurophysiological outcome measures reported by at least two different research groups, tDCS was found to have a reliable effect on only one: MEP amplitude. Interestingly, the magnitude of this effect has been significantly decreasing over the last 14 years. CONCLUSION: Our systematic review does not support the idea that tDCS has a reliable neurophysiological effect beyond MEP amplitude modulation - though important limitations of this review (and conclusion) are discussed. This work raises questions concerning the mechanistic foundations and general efficacy of this device - the implications of which extend to the steadily increasing tDCS psychological literature.

Deviating to the right: using eyetracking to study the role of attention in navigation asymmetries.

The ability to navigate accurately through the environment and avoid obstacles is essential for effective interactions with the environment. It is therefore surprising that systematic rightward errors are observed when neurologically intact participants navigate through doorways-most likely due to the operation of biases in spatial attention. These rightward errors may arise due to the operation of an extinction-like process, whereby participants overattend to the left doorpost and collide with the right one. Alternatively, rightward biases might reflect a bisection bias, such that the extrapersonal nature of the aperture causes participants to misbisect the aperture slightly to the right of true center. Because eye movements and spatial attention are closely related, in this study we used eyetracking to test the extinction and bisection models in a remote wheelchair navigation task. University students (n = 16) made rightward errors when navigating the wheelchair through a doorway, and fixated more frequently toward the right side of the aperture throughout the trial. These results are inconsistent with an extinction-based theory of navigation asymmetry, which predicts a leftward bias in eye position due to participants overattending to the left side of the doorway. Instead, the observed rightward bias in eye movements strongly supports a bisection-based theory of navigation asymmetry, whereby participants mentally "mark" the midpoint of a doorway toward the right and then head toward that point, resulting in rightward deviations. The rightward nature of participants' navigation errors and eye positions is consistent with the existence of a rightward attentional bias for extrapersonal stimuli.

Close to me: the effect of asymmetrical environments on spatial attention.

Attention can be captured by distractors and can affect performance. To examine whether asymmetrical distractors, such as a wall, affect spatial attention, Experiment 1 required participants (n = 20) to determine the relative length of pre-bisected lines when a temporary barrier was placed close to the left or right sides of the display. Post-hoc tests showed that attention was drawn towards left, but not right, walls. Experiment 2 (n = 18) sought to increase this effect using a solid brick wall rather than a temporary barrier. Instead of strengthening the result, no effect of barrier was observed. A non-effect was also observed in Experiment 3 (n = 18) when participants moved a cursor to the line's middle. Finally, Experiment 4 (n = 26) showed that asymmetrical barriers had no effect on visual search. While the data showed some evidence that attention is distracted by walls placed to the left, this effect is weak and task-specific. PRACTITIONER SUMMARY: The ability to monitor critical information on displays can be affected by asymmetrical distractors. In many workplaces, a display may be placed alongside a wall. This study explored whether a wall placed to the left/right affects spatial attention. A weak, task-specific, attraction effect was observed for walls on the left.

Transcranial direct current stimulation: five important issues we aren't discussing (but probably should be).

Transcranial Direct Current Stimulation (tDCS) is a neuromodulatory device often publicized for its ability to enhance cognitive and behavioral performance. These enhancement claims, however, are predicated upon electrophysiological evidence and descriptions which are far from conclusive. In fact, a review of the literature reveals a number of important experimental and technical issues inherent with this device that are simply not being discussed in any meaningful manner. In this paper, we will consider five of these topics. The first, inter-subject variability, explores the extensive between- and within-group differences found within the tDCS literature and highlights the need to properly examine stimulatory response at the individual level. The second, intra-subject reliability, reviews the lack of data concerning tDCS response reliability over time and emphasizes the importance of this knowledge for appropriate stimulatory application. The third, sham stimulation and blinding, draws attention to the importance (yet relative lack) of proper control and blinding practices in the tDCS literature. The fourth, motor and cognitive interference, highlights the often overlooked body of research that suggests typical behaviors and cognitions undertaken during or following tDCS can impair or abolish the effects of stimulation. Finally, the fifth, electric current influences, underscores several largely ignored variables (such as hair thickness and electrode attachments methods) influential to tDCS electric current density and flow. Through this paper, we hope to increase awareness and start an ongoing dialog of these important issues which speak to the efficacy, reliability, and mechanistic foundations of tDCS.

Spatial limitations of fast temporal segmentation are best modeled by V1 receptive fields.

The fine temporal structure of events influences the spatial grouping and segmentation of visual-scene elements. Although adjacent regions flickering asynchronously at high temporal frequencies appear identical, the visual system signals a boundary between them. These "phantom contours" disappear when the gap between regions exceeds a critical value (g(max)). We used g(max) as an index of neuronal receptive-field size to compare with known receptive-field data from along the visual pathway and thus infer the location of the mechanism responsible for fast temporal segmentation. Observers viewed a circular stimulus reversing in luminance contrast at 20 Hz for 500 ms. A gap of constant retinal eccentricity segmented each stimulus quadrant; on each trial, participants identified a target quadrant containing counterphasing inner and outer segments. Through varying the gap width, g(max) was determined at a range of retinal eccentricities. We found that g(max) increased from 0.3° to 0.8° for eccentricities from 2° to 12°. These values correspond to receptive-field diameters of neurons in primary visual cortex that have been reported in single-cell and fMRI studies and are consistent with the spatial limitations of motion detection. In a further experiment, we found that modulation sensitivity depended critically on the length of the contour and could be predicted by a simple model of spatial summation in early cortical neurons. The results suggest that temporal segmentation is achieved by neurons at the earliest cortical stages of visual processing, most likely in primary visual cortex.

Predicting perceptual decision biases from early brain activity.

Perceptual decision making is believed to be driven by the accumulation of sensory evidence following stimulus encoding. More controversially, some studies report that neural activity preceding the stimulus also affects the decision process. We used a multivariate pattern classification approach for the analysis of the human electroencephalogram (EEG) to decode choice outcomes in a perceptual decision task from spatially and temporally distributed patterns of brain signals. When stimuli provided discriminative information, choice outcomes were predicted by neural activity following stimulus encoding; when stimuli provided no discriminative information, choice outcomes were predicted by neural activity preceding the stimulus. Moreover, in the absence of discriminative information, the recent choice history primed the choices on subsequent trials. A diffusion model fitted to the choice probabilities and response time distributions showed that the starting point of the evidence accumulation process was shifted toward the previous choice, consistent with the hypothesis that choice priming biases the accumulation process toward a decision boundary. This bias is reflected in prestimulus brain activity, which, in turn, becomes predictive of future decisions. Our results provide a model of how non-stimulus-driven decision making in humans could be accomplished on a neural level.

The relationship between vertical stimulation and horizontal attentional asymmetries.

The original aim was to examine the effect of perceived distance, induced by the Ponzo illusion, on left/right asymmetries for line bisection. In Experiment 1, university students (n = 29) made left/right bisection judgements for lines presented in the lower or upper half of the screen against backgrounds of the Ponzo stimuli, or a baseline. While the Ponzo illusion had relatively little effect on line bisection, elevation in the baseline condition had a strong effect, whereby the leftward bias was increased for upper lines. Experiment 2 (n = 17) eliminated the effect of elevation by presenting the line in the middle and moving the Ponzo stimuli relative to the line. Despite this change, the leftward bias was still stronger in the upper condition in the baseline condition. The final experiment (n = 17) investigated whether upper/lower visual stimulation, which was irrelevant to the task, affected asymmetries for line bisection. The results revealed that a rectangle presented in the upper half of the screen increased the leftward line bisection bias relative to a baseline and lower stimulation condition. These results corroborate neuroimaging research, showing increased right parietal activation associated with shifts of attention into the upper hemispace. This increased right parietal activation may increase the leftward attentional bias-resulting in a stronger leftward bias for line bisection.