RESUMO
All mainstream primary schools in Cardiff were invited in July 1998 to participate in a prevalence survey of autistic spectrum disorder. Teachers of each class filled in a questionnaire based on ICD-10 criteria for autistic disorders. The Autism Spectrum Screening Questionnaire (ASSQ) was completed on children identified with problems identified by the questionnaire. A total of 11692 children born between 1 September 1986 and 31 August 1990 were screened: 234 (2%) children were identified as requiring an ASSQ; 151 of 234 (65%) ASSQs were returned. Of the 151, 60 children (52 male, 8 female; 40%) scored 22 or more. Their notes and the involved professionals were consulted. Thirty-five children, unknown to specialist services or with complex features, required additional assessment. Seventeen children (all male) were found to be on the autistic spectrum. When the overall rubric was disentangled we found a diverse population of affected children including a handful who did not fit easily into ICD-10 classification. Correcting for incomplete ascertainment we found a minimum prevalence of 20.2 out of every 10 000 (SE = 4.5) for autistic spectrum disorder in this population.
Assuntos
Síndrome de Asperger/diagnóstico , Síndrome de Asperger/epidemiologia , Transtorno Autístico/diagnóstico , Transtorno Autístico/epidemiologia , Inclusão Escolar/estatística & dados numéricos , Fatores Etários , Criança , Feminino , Inquéritos Epidemiológicos , Humanos , Masculino , Prevalência , Testes Psicológicos , Índice de Gravidade de Doença , Fatores Sexuais , País de Gales/epidemiologiaRESUMO
AIMS: To investigate whether ocular anomalies are associated with congenital heart defects in children with Down's syndrome. METHODS: 58 children with Down's syndrome were entered into a retrospective observational study. Children were assigned to heart defect groups based on medical records. Optometric tests had previously been carried out at the homes of the children. RESULTS: A relation between congenital cardiac defects, myopia, and nystagmus was observed. Heart problems were not related to accommodative insufficiency, hyperopia, or strabismus. CONCLUSION: In children with Down's syndrome heart defects were associated with both myopia and nystagmus.
Assuntos
Síndrome de Down/complicações , Cardiopatias Congênitas/complicações , Miopia/complicações , Nistagmo Patológico/complicações , Acomodação Ocular , Criança , Pré-Escolar , Estudos de Coortes , Humanos , Hiperopia/complicações , Lactente , Estudos Retrospectivos , Estrabismo/complicaçõesRESUMO
BACKGROUND: The impact of the withdrawal of long-term antipsychotic medication prescribed to adults with intellectual disabilities on behavioural functioning has been investigated using a real-time direct observation methodology. Previous authors have reported a significant post-reduction difference in engagement in activity between the successful drug reduction and control groups. METHOD: In the present study, sequential analysis of the relationship between staff:resident interaction and behavioural engagement was used to give a more precise measure of the extent to which user responsiveness is affected by drug withdrawal. Responsiveness was measured by calculating the likelihood of engagement occurring given the occurrence of staff interaction. This likelihood was represented by the statistic Yule's Q-value. RESULTS: High Yule's Q-value results pre- and post-baseline were found, indicating that clients were highly responsive to staff interaction. However, Yule's Q-value did not significantly increase following drug withdrawal. CONCLUSION: The present study provides no evidence of greater responsiveness following the withdrawal of psychotropic medication.
Assuntos
Antipsicóticos/efeitos adversos , Haloperidol/efeitos adversos , Deficiência Intelectual/complicações , Transtornos Mentais/tratamento farmacológico , Síndrome de Abstinência a Substâncias/etiologia , Tioridazina/efeitos adversos , Adulto , Idoso , Antipsicóticos/administração & dosagem , Terapia Comportamental , Terapia Combinada , Esquema de Medicação , Haloperidol/administração & dosagem , Humanos , Transtornos Mentais/epidemiologia , Transtornos Mentais/terapia , Pessoa de Meia-Idade , Variações Dependentes do Observador , Prevalência , Probabilidade , Distribuição Aleatória , Síndrome de Abstinência a Substâncias/epidemiologia , Inquéritos e Questionários , Tioridazina/administração & dosagemAssuntos
Crime/estatística & dados numéricos , Deficiência Intelectual/epidemiologia , Deficiências da Aprendizagem/epidemiologia , Comorbidade , Crime/legislação & jurisprudência , Comportamento Perigoso , Humanos , Deficiência Intelectual/diagnóstico , Deficiências da Aprendizagem/diagnóstico , Medição de Risco , Estados UnidosRESUMO
PURPOSE: To examine the relationship between defective accommodation and refractive errors in children with Down syndrome. METHODS: Children with Down syndrome aged 4 to 85 months were seen at their homes as part of an ongoing study of visual development. Seventy-five children contributed cross-sectional data and 69 children longitudinal data. Accommodation was measured using a modification of Nott dynamic retinoscopy technique, and refractive error measurements were obtained using Mohindra retinoscopy. RESULTS: Accommodation was poor, regardless of the refractive error present. The total accommodation produced by the children was related to the refractive error at the time of the test, with the degree of accommodation deficit increasing with the amount of positive refractive error. The longitudinal results showed that although children with Down syndrome did not accommodate accurately, the amount of accommodation elicited did not reflect their maximum amplitude of accommodation. Each child showed a consistent degree of underaccommodation for a given stimulus. Spectacles to correct hypermetropia did not improve the accommodative response. CONCLUSIONS: In children with Down syndrome, underaccommodation is substantial, even when there is no, or a fully corrected, refractive error. The accommodation system of children with Down syndrome may have the physical capacity to respond to a given stimulus, but the neural control of the system has an anomalous set point. Spectacles do not remedy the situation. This has important implications, especially for children in a learning environment, because near vision is consistently out of focus.
Assuntos
Acomodação Ocular , Síndrome de Down/complicações , Erros de Refração/complicações , Transtornos da Visão/complicações , Envelhecimento/fisiologia , Criança , Pré-Escolar , Estudos Transversais , Síndrome de Down/fisiopatologia , Óculos , Humanos , Lactente , Estudos Longitudinais , Erros de Refração/fisiopatologia , Erros de Refração/terapia , Transtornos da Visão/fisiopatologia , Transtornos da Visão/terapia , Testes VisuaisRESUMO
PURPOSE: To investigate possible factors that may be implicated in the poor accommodative responses of individuals with Down syndrome. This article evaluates the effect of age, angular size of target, and cognitive factors on accommodation. METHODS: Seventy-seven children with Down syndrome who are participating in an ongoing study of visual development were assessed. One hundred thirty-one developmentally normal children took part in a previous study and provided control data. Accommodation was measured using a modified Nott dynamic retinoscopy technique. RESULTS: Children with Down syndrome showed considerably poorer accommodative responses than normally developing children. No target used in the present study produced an improved response in children with Down syndrome. Age, angular subtense of target, and cognitive factors could not fully account for the poor accommodation in children with Down syndrome. CONCLUSIONS: Poor accommodation is a common feature of Down syndrome, regardless of the target used. The etiology of the deficit has yet to be established. It is imperative that educators and clinicians are aware that near vision is out of focus for these children.
Assuntos
Acomodação Ocular/fisiologia , Envelhecimento/fisiologia , Cognição/fisiologia , Síndrome de Down/fisiopatologia , Transtornos da Visão/fisiopatologia , Adulto , Criança , Pré-Escolar , Feminino , Humanos , Lactente , Masculino , Testes Visuais , Acuidade VisualRESUMO
Significant refractive errors are common among older children and adults with Down syndrome. We examined infants and children with Down syndrome to determine the prevalence of these errors at younger ages. Noncycloplegic retinoscopy was used to determine the refractive state of 92 infants and children with Down syndrome, aged 4 months to 12 years. The results for infants show a similar distribution of refractive errors in patients with Down syndrome and an age-matched control group. However, rather than a narrower distribution for the older age groups, as is the case with the controls, the distribution is wider, and the prevalence of refractive errors (including astigmatism) is higher among young children with Down syndrome than among controls. This high prevalence of refractive defects cannot be explained by the presence of strabismus or other pathologies.
Assuntos
Síndrome de Down/complicações , Erros de Refração/complicações , Criança , Pré-Escolar , Síndrome de Down/fisiopatologia , Humanos , Lactente , Prevalência , Erros de Refração/epidemiologia , Erros de Refração/fisiopatologia , País de Gales/epidemiologiaRESUMO
On 29 June 1996 a conference was held in Birmingham to highlight the status of epilepsy in people with learning disabilities. The conference consisted both of seminars and workshops. Dr Tim Betts, Birmingham; Dr Greg O'Brien, Northumberland; and Dr Mike Kerr addressed issues of assessment, diagnosis and drug treatment of epilepsy in this population. This meeting report summarizes the proceedings of the conference.
Assuntos
Epilepsia/complicações , Deficiências da Aprendizagem/complicações , Anticonvulsivantes/uso terapêutico , Diagnóstico Diferencial , Erros de Diagnóstico , Inglaterra , Epilepsia/diagnóstico , Epilepsia/tratamento farmacológico , Humanos , Deficiências da Aprendizagem/diagnóstico , Deficiências da Aprendizagem/psicologia , Qualidade de VidaRESUMO
A prevalence study of autistic disorder (AD) in childhood was undertaken in a Welsh health district as part of a needs' assessment exercise. The study population were all children resident in the district with dates of birth between 1977 and 1988. Children were identified after a trawl of service providers in health and education and diagnosis was confirmed at a multidisciplinary assessment. An increase in prevalence was found, an observation that has been made in other parts of the world. The increase in prevalence, whether real or administratively apparent, has major implications for service providers in health, education, and social care, in that a larger number of children are being recognised as having a triad of impairments which requires very specific interventions and support from all three agencies.
Assuntos
Transtorno Autístico/epidemiologia , Prevalência , Criança , Pré-Escolar , Feminino , Humanos , Masculino , Reino UnidoRESUMO
Accommodation and visual acuity were measured in 53 children with Down's syndrome aged between 12 weeks and 57 months. Results were compared with data for 136 control (typically developing) children aged between 4 weeks and 48 months. Whereas the control children accommodated accurately on near targets, accommodation was defective in 92% of the children with Down's syndrome, and there was no change in accommodative ability with age. On the other hand, visual acuity lay within normal limits for the younger children. Children over the age of 2 years showed a below-normal visual acuity, which is not explained either by refractive error or by the effect of poor accommodation. The data suggest a sudden change in the rate of development of visual acuity which may be associated with physiological changes in the visual cortex. Previously reported defects of accommodation and visual acuity in older children and adults with Down's syndrome are confirmed by our findings in infants and young children.
Assuntos
Acomodação Ocular , Síndrome de Down , Transtornos da Visão/terapia , Acuidade Visual , Pré-Escolar , Síndrome de Down/complicações , Humanos , Lactente , Erros de Refração , Transtornos da Visão/complicações , Transtornos da Visão/diagnósticoRESUMO
This paper describes the development of a scale for assessing clinicians' communication with people with profound learning disability. Four psychiatrists and four nurses were assessed completing three simple non-invasive clinical procedures--blood pressure, pulse and axillary temperature--with people with profound learning disability. Videotaped assessment of consultations was performed by three experienced speech and language therapists using a previously designed scale for analysing encounters with people with mild learning disability. This led to the production of a new scale specifically for people with profound learning disability. A significant inter-rater reliability was found between the three speech therapists for total scores (rater a-b, corr = 0.654, P = 0.006; rater a-c, corr = 0.795, P = 0.0001: rater b-c, corr = 0.673, P = 0.004). Significant reliability between raters was also found for the subsections of verbal behaviour and non-verbal behaviour.
Assuntos
Comunicação , Deficiência Intelectual , Relações Profissional-Paciente , Pressão Sanguínea , Humanos , Comunicação não Verbal , Variações Dependentes do Observador , Índice de Gravidade de Doença , Gravação de VideoteipeRESUMO
Autopsies were carried out on 60 mentally handicapped patients and the brain was examined in detail in all cases. The clinical records were studied and correlated with the pathological findings. A variety of pathological changes were found in the central nervous system, and there was a high incidence of microcephaly and gross abnormalities among the patients with epilepsy and neurological dysfunction. The incidence of Alzheimer's disease was very high among patients with Down's syndrome, but in those patients without Down's syndrome, the incidence appeared to be much the same as in the general population. The most common cause of death was respiratory disease, followed by cardiovascular disease. There was a high incidence of volvulus among the group with epilepsy. The findings are discussed, and reference made to the long-term care of the mentally handicapped. The study demonstrates the importance of the autopsy in terms of furthering knowledge in the field of mental handicap.
Assuntos
Dano Encefálico Crônico/patologia , Encéfalo/patologia , Síndrome de Down/patologia , Deficiência Intelectual/patologia , Adulto , Idoso , Idoso de 80 Anos ou mais , Doença de Alzheimer/patologia , Precursor de Proteína beta-Amiloide/análise , Causas de Morte , Epilepsia/patologia , Feminino , Humanos , Técnicas Imunoenzimáticas , Masculino , Pessoa de Meia-Idade , Emaranhados Neurofibrilares/patologiaRESUMO
This study reports the results of an initial study into the ability of psychiatrists to interview people with a mild mental handicap who are accompanied by a caregiver. Initial interviews by 12 psychiatrists of different ages (30-57 years) and differing levels of experience with this client group were recorded on video tape. Three of the recordings were used to train four judges who were familiar with examining clinical interactions, though not between doctors and patients. The judges used a specially designed rating scale. The remaining nine interviews were evaluated independently by the four judges. There was a correlation of 0.65 (Kendall's coefficient of concordance, W) for the judges' evaluations using the rating scale for the nine interviewers. However, there was greater agreement between judges as to who were the best and worst interviewers (W = 0.86). Some of the aspects of the interviews which contributed to the variability in the judgments are discussed.
Assuntos
Comunicação , Deficiência Intelectual/diagnóstico , Entrevistas como Assunto/normas , Relações Médico-Paciente , Psiquiatria/normas , Adulto , Cuidadores , Competência Clínica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Comunicação não Verbal , Comportamento VerbalRESUMO
To investigate whether language in schizophrenia deteriorated progressively, 11 schizophrenic subjects, 9 manic subjects and 9 controls were re-tested after an interval of three years using the computer-assisted syntactical analysis technique of Morice. In 13 of the 16 linguistic variables described as hallmarks of schizophrenic speech decline, deterioration was noted in schizophrenics in the direction predicted and relative to the manic and control groups. The deterioration was most pronounced in complexity and integrity of speech. One variable remained unchanged and two (semantic variables) showed marginal improvement. It was concluded that language, and in particular syntax, does deteriorate in the schizophrenic process.
Assuntos
Transtorno Bipolar/psicologia , Idioma , Psicologia do Esquizofrênico , Humanos , LinguísticaRESUMO
A computer-assisted analysis of samples of free speech from acute schizophrenics (n = 50), chronic schizophrenics (n = 27) and normal subjects (n = 50) enabled a comparison of the linguistic profiles of the three groups. The chronic group consistently emerged as the most impaired, on measures of complexity, integrity (error) and fluency of speech, with the acute patients performing less well than normal speakers but better than chronic patients. Demographic differences could account for only a small number of the linguistic differences. A comparison of chronic schizophrenics from the community and those from long-stay wards suggested that their poor linguistic performance was in some way related to the illness process and not to institutionalisation. Three possible explanations for these results were considered, particularly the possibility that low complexity of speech, negative symptoms and poor outcome are in some way related.