VV-ECMO in critical COVID-19 obese patients: a cohort study.

BACKGROUND: Obesity causes significant difficulties in successful extracorporeal membrane oxygenation (ECMO) support and may interfere with patient outcomes. During the COVID-19 pandemic, we experienced an increased number of obese patients supported with ECMO in our intensive care unit due to severe illness in this population. METHODS: We designed a single-center retrospective study to identify prognostic factors for 180-day survival in obese critical COVID-19 patients receiving venovenous ECMO (VV-ECMO). We included adult critical COVID-19 patients on VV-ECMO, who were obese and overweight (according to the World Health Organization) and admitted to a tertiary hospital's intensive care unit from April 1, 2020, to May 31, 2022. Univariate logistic regression analysis was performed to assess differences in 180-day mortality. RESULTS: Forty-one patients were included. The median age was 55 (IQR 45-60) years, and 70.7% of the patients were male. The median body mass index (BMI) was 36 (IQR 31-42.5) kg/m2; 39% of patients had a BMI ≥ 40 kg/m2. The participants had 3 (IQR 1.5-4) days of mechanical ventilation prior to ECMO, and 63.4% were weaned from VV-ECMO support after a median of 19 (IQR 10-34) days. The median ICU length of stay was 31.9 (IQR 17.5-44.5) days. The duration of mechanical ventilation was 30 (IQR 19-49.5) days. The 180-day mortality rate was 41.5%. Univariate logistic regression analysis revealed that a higher BMI was associated with greater 180-day survival (OR 1.157 [1.038-1.291], p = 0.009). Younger age, female sex, less invasive ventilation time before ECMO, and fewer complications at the time of ECMO cannulation were associated with greater 180-day survival [OR 0.858 (0.774-0.953), p 0.004; OR 0.074 (0.008-0.650), p 0.019; OR 0.612 (0.401-0.933), p 0.022; OR 0.13 (0.03-0.740), p 0.022), respectively]. CONCLUSION: In this retrospective cohort of critical COVID-19 obese adult patients supported by VV-ECMO, a higher BMI, younger age, and female sex were associated with greater 180-day survival. A shorter invasive ventilation time before ECMO and fewer complications at ECMO cannulation were also associated with increased survival.

Complex neural tube and skeletal malformations, resembling Chiari malformations, in two calves.

Two 1-day-old full-term female calves from different farms located in the Brazilian state of Rio Grande do Sul were unable to stand due to paresis of the pelvic limbs. Both calves had spina bifida on the spinal lumbar segment and were submitted to euthanasia due to poor prognosis. Postmortem examination revealed cerebellar herniation, caudal displacement of the brainstem, rostral deviation of the cranial nerves, caudal extension of occipital lobes, absence of dorsal lamina of lumbar vertebrae with exposed spinal cord, myelodysplasia, kyphosis, segmental spinal agenesis, renal fusion, muscular atrophy, and arthrogryposis. Histology highlighted myelodysplasia (syringomyelia and diplomyelia) and muscular atrophy. The reverse transcription-polymerase chain reactions for ruminant pestivirus were negative. Based on these lesions, the diagnosis of complex neural tube and skeletal malformations was made. A review of previous publications on calves diagnosed with these malformations, originally called Chiari or Arnold-Chiari malformations, revealed a wide range of nervous system and skeletal lesions. These variations amplified the uncertainty regarding whether all cases represent the same disorder and reinforced the importance of reconfiguring the terminology.

A cidade não pode parar: a Maratona do Rio de Janeiro em 2020 na era da pandemia / The city cannot stop: the Rio de Janeiro Marathon in the era of the pandemic / La ville ne peut pas s'arrêter: le Marathon de Rio de Janeiro à l'ère de la pandémie

Neste artigo, iremos apresentar como ocorreu a edição virtual da Maratona do Rio de Janeiro em 2020, ainda sem autorizações sanitárias para a realização de grandes eventos. Para isso, analisaremos o Guia do corredor, apresentado aos corredores na época. A competição é realizada por meio de uso de aplicativos, mas o atleta é estimulado a correr com o slogan "Não correr nunca foi uma opção". Abordamos os conceitos de necrodemografia e necropolítica. Entende-se que a Maratona do Rio pratica uma espécie de necropolíti-ca ao organizar a competição em pleno período pandêmico do Brasil, apesar de valorizar a paisagem da rua em suas plataformas comunicacionais.

In this article, we will present how the virtual edition of the Rio de Janeiro Marathon took place in 2020 in the middle of the pandemic, still without health permits to hold major events. For this, we will analyze the Runner's Guide presented to the runners at the time. The competition is carried out using applications, but the athlete is encouraged to run with the slogan "Not running was never an option". We approach the concepts of necrodemography and necropolitics. It is understood that the Rio Marathon practices a kind of necropolitics when organizing the competition in the middle of the pandemic period in Brazil, despite valuing the street landscape in its communication platforms.

Dans cet article, nous allons vous présenter comment s'est déroulée l'édition virtuelle du Marathon de Rio de Janeiro en 2020, toujours sans autorisations sanitaires pour les grands événements. Pour cela, nous analyserons le Guide du marathonien, présenté aux marathoniens à l'époque. La compétition se déroule à l'aide d'applications, mais l'athlète est encouragé à courir avec le slogan "Ne pas courir n'a jamais été une option". Nous abordons les concepts de nécrodémographie et de nécropolitique. Il est entendu que le Marathon de Rio pratique une sorte de nécropolitique en organisant la compétition en pleine pandémie au Brésil, malgré la valorisation du paysage de rue dans ses plateformes de communication.

Ultrasound in cervical traumatic neuromas after neck dissection in thyroid carcinoma patients: descriptive analysis and diagnostic accuracy.

Objective: Cervical traumatic neuromas (CTNs) may appear after lateral neck dissection for metastatic thyroid carcinoma. If they are misdiagnosed as metastatic lymph nodes (LNs) in follow-up neck ultrasound (US), unnecessary and uncomfortable fine-needle aspiration biopsy are indicated. The present study aimed to describe US features of CTNs and to assess the US performance in distinguishing CTNs from abnormal LNs. Subjects and methods: Retrospective evaluation of neck US images of 206 consecutive patients who had lateral neck dissection as a part of thyroid cancer treatment to assess CTN´s US features. Diagnostic accuracy study to evaluate US performance in distinguishing CTNs from abnormal LNs was performed. Results: Eight-six lateral neck nodules were selected for analysis: 38 CTNs and 48 abnormal LNs. CTNs with diagnostic cytology were predominantly hypoechogenic (100% vs. 45%; P = 0.008) and had shorter diameters than inconclusive cytology CTNs: short axis (0.39 cm vs. 0.50 cm; P = 0.03) and long axis (1.64 cm vs. 2.35 cm; P = 0.021). The US features with the best accuracy to distinguish CTNs from abnormal LNs were continuity with a nervous structure, hypoechogenic internal lines, short/long axis ratio ≤ 0.42, absent Doppler vascularization, fusiform morphology, and short axis ≤ 0.48 cm. Conclusion: US is a very useful method for assessing CTNs, with good performance in distinguishing CTNs from abnormal LNs.

Stroke with postoperative visual loss as the first clinical manifestation of antiphospholipid antibody syndrome: Case report.

INTRODUCTION: Postoperative visual loss (POVL) is a rare and devastating complication. Its incidence in nonophthamologic surgeries varies from 0.056 % to 1.3 %. Autoimmune rheumatic diseases with a predisposition to thrombotic events, such as antiphospholipid antibody syndrome (APS), may constitute an important risk factor for this complication. PRESENTATION OF CASE: A 34-year-old female patient, who was a former smoker and had no other comorbidities. She underwent orthopedic surgery and presented with bilateral POVL associated with the loss of secondary muscle strength and intraoperative venous and arterial cerebral thrombosis. She was thoroughly investigated regarding the etiology of her condition, and high levels of antiphospholipid antibodies were found. DISCUSSION: APS is an autoimmune disease that predisposes the patient to thrombotic events. Among these, stroke is one of the main causes of POVL secondary to ischemia of the cortical territory, or also known as "cortical blindness." CONCLUSION: The rare incidence of POVL in nonophthalmological surgeries and the consequence and preservation in the literature on the subject, explain the limitations of its pathophysiology, and especially the development of guidelines focused on the prevention of patients with risk factors for this condition. Thus, this case report warns about the risks and anesthetic care that patients with risk factors should have when undergoing nonophthalmological surgeries.

Acute and chronic changes in porcine rete mirabile after embolization with the Menox system: angiographic and histopathological analyses.

Objective: To evaluate acute and chronic changes seen on angiographic and histopathological studies of porcine rete mirabile, comparing those treated with the Menox liquid embolic system (LES) and those treated with the Onyx LES. Materials and Methods: Five pigs, each weighing approximately 35 kg, were submitted to rete mirabile embolization under general anesthesia and fluoroscopic guidance, with the Menox LES or Onyx LES. Four animals were treated with the Menox LES and underwent cerebral angiography, followed by euthanasia, at 1, 30, 60, and 90 days after embolization. One animal was treated with the Onyx LES underwent the same procedures at 30 days after embolization. In a subsequent histopathological analysis, we compared the Menox LES and Onyx LES in terms of the acute and chronic changes observed. Results: We observed no significant changes in blood pressure, heart rate, or electrocardiographic parameters that could be attributed to the super-selective infusion of dimethyl sulfoxide or the Menox embolic agent. Fluoroscopy showed adequate material opacity, appropriate progression to the center of the rete mirabile and complete unilateral embolization. Microcatheters were uneventfully detached from the embolized nidus. We observed mild to moderate intravascular and extravascular inflammatory responses, without histological evidence of necrotizing arteritis. There were no adverse neurovascular events. Conclusion: The Menox LES appears to be safe and effective, as well as being apparently equivalent to the Onyx LES in terms of the postprocedure angiographic and histopathological findings.

Objetivo: Avaliar as alterações angiográficas e histopatológicas agudas e crônicas em rete mirabile suína tratadas com o Menox liquid embolic system (LES) e comparar essas alterações com a embolização com Onyx LES. Materiais e Métodos: A embolização da rete mirabile com Menox LES e Onyx LES foi realizada em cinco suínos pesando cerca de 35 kg sob anestesia geral e orientação fluoroscópica. Quatro animais tratados com Menox LES foram submetidos a angiografia cerebral seguida de eutanásia após 1, 30, 60 e 90 dias e um animal tratado com Onix LES foi submetido ao mesmo procedimento após 30 dias. A análise histopatológica subsequente para alterações agudas e crônicas avaliou o desempenho do Menox LES comparado ao Onyx LES. Resultados: Não foram observadas alterações significativas atribuíveis à infusão superseletiva de dimetilsulfóxido ou Menox nos parâmetros de pressão arterial, frequência cardíaca ou eletrocardiograma. A fluoroscopia mostrou opacidade adequada do material, progressão adequada para o centro da rete mirabile e embolização unilateral completa. Os microcateteres foram retirados do nidus embolizado sem complicações. Observou-se resposta inflamatória intravascular e extravascular leve a moderada, sem indício histológico de arterite necrosante. Nenhum dos casos apresentou eventos neurovasculares adversos. Conclusão: A injeção de Menox LES mostrou-se segura e eficaz, além de ser equivalente ao Onyx LES em relação aos achados angiográficos e histopatológicos pós-procedimento.

Acute and chronic changes in porcine rete mirabile after embolization with the Menox system: angiographic and histopathological analyses / Alterações angiográficas e histopatológicas agudas e crônicas da rete mirabile no modelo suíno com sistema embólico líquido Menox

Abstract Objective: To evaluate acute and chronic changes seen on angiographic and histopathological studies of porcine rete mirabile, comparing those treated with the Menox liquid embolic system (LES) and those treated with the Onyx LES. Materials and Methods: Five pigs, each weighing approximately 35 kg, were submitted to rete mirabile embolization under general anesthesia and fluoroscopic guidance, with the Menox LES or Onyx LES. Four animals were treated with the Menox LES and underwent cerebral angiography, followed by euthanasia, at 1, 30, 60, and 90 days after embolization. One animal was treated with the Onyx LES underwent the same procedures at 30 days after embolization. In a subsequent histopathological analysis, we compared the Menox LES and Onyx LES in terms of the acute and chronic changes observed. Results: We observed no significant changes in blood pressure, heart rate, or electrocardiographic parameters that could be attributed to the super-selective infusion of dimethyl sulfoxide or the Menox embolic agent. Fluoroscopy showed adequate material opacity, appropriate progression to the center of the rete mirabile and complete unilateral embolization. Microcatheters were uneventfully detached from the embolized nidus. We observed mild to moderate intravascular and extravascular inflammatory responses, without histological evidence of necrotizing arteritis. There were no adverse neurovascular events. Conclusion: The Menox LES appears to be safe and effective, as well as being apparently equivalent to the Onyx LES in terms of the postprocedure angiographic and histopathological findings.

Resumo Objetivo: Avaliar as alterações angiográficas e histopatológicas agudas e crônicas em rete mirabile suína tratadas com o Menox liquid embolic system (LES) e comparar essas alterações com a embolização com Onyx LES. Materiais e Métodos: A embolização da rete mirabile com Menox LES e Onyx LES foi realizada em cinco suínos pesando cerca de 35 kg sob anestesia geral e orientação fluoroscópica. Quatro animais tratados com Menox LES foram submetidos a angiografia cerebral seguida de eutanásia após 1, 30, 60 e 90 dias e um animal tratado com Onix LES foi submetido ao mesmo procedimento após 30 dias. A análise histopatológica subsequente para alterações agudas e crônicas avaliou o desempenho do Menox LES comparado ao Onyx LES. Resultados: Não foram observadas alterações significativas atribuíveis à infusão superseletiva de dimetilsulfóxido ou Menox nos parâmetros de pressão arterial, frequência cardíaca ou eletrocardiograma. A fluoroscopia mostrou opacidade adequada do material, progressão adequada para o centro da rete mirabile e embolização unilateral completa. Os microcateteres foram retirados do nidus embolizado sem complicações. Observou-se resposta inflamatória intravascular e extravascular leve a moderada, sem indício histológico de arterite necrosante. Nenhum dos casos apresentou eventos neurovasculares adversos. Conclusão: A injeção de Menox LES mostrou-se segura e eficaz, além de ser equivalente ao Onyx LES em relação aos achados angiográficos e histopatológicos pós-procedimento.

Ultrasound in cervical traumatic neuromas after neck dissection in thyroid carcinoma patients: descriptive analysis and diagnostic accuracy

ABSTRACT Objective: Cervical traumatic neuromas (CTNs) may appear after lateral neck dissection for metastatic thyroid carcinoma. If they are misdiagnosed as metastatic lymph nodes (LNs) in follow-up neck ultrasound (US), unnecessary and uncomfortable fine-needle aspiration biopsy are indicated. The present study aimed to describe US features of CTNs and to assess the US performance in distinguishing CTNs from abnormal LNs. Subjects and methods: Retrospective evaluation of neck US images of 206 consecutive patients who had lateral neck dissection as a part of thyroid cancer treatment to assess CTN's US features. Diagnostic accuracy study to evaluate US performance in distinguishing CTNs from abnormal LNs was performed. Results: Eight-six lateral neck nodules were selected for analysis: 38 CTNs and 48 abnormal LNs. CTNs with diagnostic cytology were predominantly hypoechogenic (100% vs. 45%; P = 0.008) and had shorter diameters than inconclusive cytology CTNs: short axis (0.39 cm vs. 0.50 cm; P = 0.03) and long axis (1.64 cm vs. 2.35 cm; P = 0.021). The US features with the best accuracy to distinguish CTNs from abnormal LNs were continuity with a nervous structure, hypoechogenic internal lines, short/long axis ratio ≤ 0.42, absent Doppler vascularization, fusiform morphology, and short axis ≤ 0.48 cm. Conclusion: US is a very useful method for assessing CTNs, with good performance in distinguishing CTNs from abnormal LNs.

A "realidade do saber e da habilidade que se inculca": clima, médicos e saúde pública no Brasil, 1808-1835 / The "reality of the knowledge and the ability instilled": climate, doctors, and public health in Brazil, 1808-1835

Resumo Esse artigo analisa os esforços de construção de espaços próprios à intelectualidade médica no Brasil a partir da transferência da Corte de Lisboa para o Rio de Janeiro em 1808, passando pelo processo de independência do país, até a criação da Academia Imperial de Medicina, em 1835. A partir dessas iniciativas, procurou-se afirmar a proeminência do saber médico-científico diante das práticas de cura tradicionais, bem como uma agenda higiênica para a nação independente, fortemente atrelada à legitimação de uma expertise local sobre a climatologia brasileira. Ao longo desse processo, algumas lideranças médicas envolvidas buscavam afirmar a convergência entre o discurso higiênico e os interesses do Estado imperial nascente, ao mesmo tempo em que anunciavam renovar os mecanismos de legitimação da carreira que, supostamente, passavam a se dar pelo mérito científico em detrimento dos favorecimentos clientelares típicos do Antigo Regime.

Abstract This article analyzes the efforts to build spaces for the medical community in Brazil since the transfer of the Court from Lisbon to Rio de Janeiro in 1808, through the country's independence process, until the creation of the Imperial Academy of Medicine, in 1835. Such initiatives affirm the prominence of medical-scientific knowledge in the face of traditional healing practices, as well as a hygienic agenda for the independent nation, strongly linked to the legitimation of local expertise in Brazilian climatology. Throughout this process, some medical leaders involved sought to affirm the convergence between the hygienic discourse and the interests of the nascent imperial state, while at the same time announcing the renewal of the mechanisms of legitimation of the career that, supposedly, started to be given by scientific merit instead of the patronage system typical of the Ancien Régime.

A saúde como campo de batalha: doenças e artes de curar no Brasil, 1750-1822 / Health as a battlefield: diseases and the healing arts in Brazil, 1750-1822

Resumo O artigo explora como as doenças eram pensadas e enfrentadas na América portuguesa no início da década de 1820, pouco antes da consolidação da ruptura política com Portugal que tornou o Brasil um país independente. Analisa quem foram os indivíduos chamados para tratar as doenças da população sofredora, seus saberes e terapêuticas. Para tanto, inicia-se com um recuo no tempo, enfatizando as influências das reformas do Império português sobre o saber médico na segunda metade do século XVIII. A primeira parte do artigo se dedica a explorar as complexas e multifacetadas práticas de cura na América portuguesa, resultantes das misturas entre as concepções tradicionais sobre o corpo e a doença que faziam parte das referências culturais da população local. Em seguida, analisa alguns dos embates institucionais e políticos envolvidos na consolidação da medicina científica no Brasil, especialmente após a transferência da Corte portuguesa para o Rio de Janeiro. Apesar do prestígio político dos médicos acadêmicos, os praticantes das artes da cura contavam com amplo apoio da população, além de encontrarem mobilidade social nas brechas das relações clientelistas que marcavam a cultura política do período.

Abstract This article explores how diseases were contemplated and faced in Portuguese America in the early 1820s, shortly before the consolidation of the political rupture with Portugal that made Brazil an independent country. It analyzes who the individuals called to treat the diseases of the suffering population were, along with their knowledge and their therapies. To achieve this, we must begin by taking a step back in time, emphasizing the influences of the reforms of the Portuguese Empire on medical knowledge in the second half of the eighteenth century. The first section of the article is dedicated to exploring the complex and multifaceted healing practices in Portuguese America, resulting from the mixtures between traditional concepts about the body and the diseases that were part of the cultural references of the local population. The article then moves on to analyze some of the institutional and political conflicts involved in the consolidation of scientific medicine in Brazil, especially after the transfer of the Portuguese Court to Rio de Janeiro. Despite the political prestige of academic doctors, practitioners of the healing arts had broad support from the population, in addition to finding social mobility in the breaches of clientelistic relationships that marked the political culture of the period.

Da Independência ao Império: saúde e doença no Brasil do século XIX / From Independence to Empire: health and disease in Brazil in the nineteenth century

Resumo Como apresentação do dossiê "Da Independência ao Império: saúde e doença no Brasil no século XIX", o artigo contrasta o "Brasil moderno" imaginado pelas elites médicas e políticas por ocasião do I Centenário da Independência, em 1922, com os inúmeros problemas e desafios no campo da saúde que a República, em sua terceira década, herdou dos períodos colonial e imperial. Além disso, destaca questões da história da saúde no século XIX que permitem aos leitores do dossiê refletir sobre as promessas civilizacionais não cumpridas de 1822-1922, à luz dos imensos desafios do ano de 2022, quando o Brasil completa duzentos anos de soberania política.

Abstract As a presentation of the dossier "From Independence to Empire: health and disease in Brazil in the nineteenth century," the article contrast "modern Brazil" imagined by the medical and political elites on the occasion of the First Centenary of Independence in 1922 with the numerous problems and challenges in the field of health that the republic, in its third decade, had inherited from the colonial and Imperial periods. In addition, it highlights issues in the history of health in the 19th century that allow the readers of the dossier to reflect on the unfulfilled civilizational promises of 1822-1922 in light of the immense challenges of the year 2022 when Brazil completes two hundred years of political sovereignty.

From Independence to Empire: health and disease in Brazil in the nineteenth century. / Da Independência ao Império: saúde e doença no Brasil do século XIX.

As a presentation of the dossier "From Independence to Empire: health and disease in Brazil in the nineteenth century," the article contrast "modern Brazil" imagined by the medical and political elites on the occasion of the First Centenary of Independence in 1922 with the numerous problems and challenges in the field of health that the republic, in its third decade, had inherited from the colonial and Imperial periods. In addition, it highlights issues in the history of health in the 19th century that allow the readers of the dossier to reflect on the unfulfilled civilizational promises of 1822-1922 in light of the immense challenges of the year 2022 when Brazil completes two hundred years of political sovereignty.

Como apresentação do dossiê "Da Independência ao Império: saúde e doença no Brasil no século XIX", o artigo contrasta o "Brasil moderno" imaginado pelas elites médicas e políticas por ocasião do I Centenário da Independência, em 1922, com os inúmeros problemas e desafios no campo da saúde que a República, em sua terceira década, herdou dos períodos colonial e imperial. Além disso, destaca questões da história da saúde no século XIX que permitem aos leitores do dossiê refletir sobre as promessas civilizacionais não cumpridas de 1822-1922, à luz dos imensos desafios do ano de 2022, quando o Brasil completa duzentos anos de soberania política.

Health as a battlefield: diseases and the healing arts in Brazil, 1750-1822. / A saúde como campo de batalha: doenças e artes de curar no Brasil, 1750-1822.

This article explores how diseases were contemplated and faced in Portuguese America in the early 1820s, shortly before the consolidation of the political rupture with Portugal that made Brazil an independent country. It analyzes who the individuals called to treat the diseases of the suffering population were, along with their knowledge and their therapies. To achieve this, we must begin by taking a step back in time, emphasizing the influences of the reforms of the Portuguese Empire on medical knowledge in the second half of the eighteenth century. The first section of the article is dedicated to exploring the complex and multifaceted healing practices in Portuguese America, resulting from the mixtures between traditional concepts about the body and the diseases that were part of the cultural references of the local population. The article then moves on to analyze some of the institutional and political conflicts involved in the consolidation of scientific medicine in Brazil, especially after the transfer of the Portuguese Court to Rio de Janeiro. Despite the political prestige of academic doctors, practitioners of the healing arts had broad support from the population, in addition to finding social mobility in the breaches of clientelistic relationships that marked the political culture of the period.

O artigo explora como as doenças eram pensadas e enfrentadas na América portuguesa no início da década de 1820, pouco antes da consolidação da ruptura política com Portugal que tornou o Brasil um país independente. Analisa quem foram os indivíduos chamados para tratar as doenças da população sofredora, seus saberes e terapêuticas. Para tanto, inicia-se com um recuo no tempo, enfatizando as influências das reformas do Império português sobre o saber médico na segunda metade do século XVIII. A primeira parte do artigo se dedica a explorar as complexas e multifacetadas práticas de cura na América portuguesa, resultantes das misturas entre as concepções tradicionais sobre o corpo e a doença que faziam parte das referências culturais da população local. Em seguida, analisa alguns dos embates institucionais e políticos envolvidos na consolidação da medicina científica no Brasil, especialmente após a transferência da Corte portuguesa para o Rio de Janeiro. Apesar do prestígio político dos médicos acadêmicos, os praticantes das artes da cura contavam com amplo apoio da população, além de encontrarem mobilidade social nas brechas das relações clientelistas que marcavam a cultura política do período.

The "reality of the knowledge and the ability instilled": climate, doctors, and public health in Brazil, 1808-1835. / A "realidade do saber e da habilidade que se inculca": clima, médicos e saúde pública no Brasil, 1808-1835.

This article analyzes the efforts to build spaces for the medical community in Brazil since the transfer of the Court from Lisbon to Rio de Janeiro in 1808, through the country's independence process, until the creation of the Imperial Academy of Medicine, in 1835. Such initiatives affirm the prominence of medical-scientific knowledge in the face of traditional healing practices, as well as a hygienic agenda for the independent nation, strongly linked to the legitimation of local expertise in Brazilian climatology. Throughout this process, some medical leaders involved sought to affirm the convergence between the hygienic discourse and the interests of the nascent imperial state, while at the same time announcing the renewal of the mechanisms of legitimation of the career that, supposedly, started to be given by scientific merit instead of the patronage system typical of the Ancien Régime.

Esse artigo analisa os esforços de construção de espaços próprios à intelectualidade médica no Brasil a partir da transferência da Corte de Lisboa para o Rio de Janeiro em 1808, passando pelo processo de independência do país, até a criação da Academia Imperial de Medicina, em 1835. A partir dessas iniciativas, procurou-se afirmar a proeminência do saber médico-científico diante das práticas de cura tradicionais, bem como uma agenda higiênica para a nação independente, fortemente atrelada à legitimação de uma expertise local sobre a climatologia brasileira. Ao longo desse processo, algumas lideranças médicas envolvidas buscavam afirmar a convergência entre o discurso higiênico e os interesses do Estado imperial nascente, ao mesmo tempo em que anunciavam renovar os mecanismos de legitimação da carreira que, supostamente, passavam a se dar pelo mérito científico em detrimento dos favorecimentos clientelares típicos do Antigo Regime.