RESUMO
Apert Syndrome, also called acrocephalosyndactylia type 1, is characterized by craniostenosis with early fusion of sutures of the vault and/or cranial base, associated to mid-face hypoplasia, symmetric syndactylia of the hands and feet and other systemic malformations. CNS malformations and intracranial hypertension are frequently observed in these patients. Early surgical treatment aims to minimize the deleterious effects of intracranial hypertension. Fronto-orbital advancement, the usual surgical technique, increases the intracranial Volume and improves the disposition of encephalic structures previously deformed by a short skull. This study analyzes CNS alterations revealed by magnetic resonance in 18 patients presenting Apert Syndrome, and the conformational alterations in the encephalic structures after surgical treatment. The patients' age in February 2001 ranged from 14 to 322 Months (m=107). Image study included brain magnetic resonance showing ventricular enlargement in five cases (27.8%), corpus callosum hypoplasia in five cases (27.8%), septum pellucidum hypoplasia in five cases (27.8%), cavum vergae in two cases (11.1%) and, arachnoid cyst in the posterior fossa in two cases (11.1%). Absence of CNS alterations was noted in 44.4% of cases. A corpus callosum morphologic index was established by dividing its height by its length, which revealed values that ranged from 0.4409 to 1.0237. The values of this index were correlated to the occurrence or absence of surgical treatment (p=0.012; t=2.83). Data analysis allowed the conclusion that the corpus callosum morphologic measure quantified the conformational alterations of the cerebral structures determined by the surgical treatment.
Assuntos
Acrocefalossindactilia/complicações , Acrocefalossindactilia/cirurgia , Adolescente , Adulto , Encefalopatias/complicações , Encefalopatias/cirurgia , Sistema Nervoso Central/anormalidades , Sistema Nervoso Central/diagnóstico por imagem , Criança , Pré-Escolar , Procedimentos Cirúrgicos Eletivos , Feminino , Humanos , Lactente , Imageamento por Ressonância Magnética , Masculino , Conformação Molecular , Radiografia , Resultado do TratamentoRESUMO
Depressed natural killer (NK) cell activity has been showed in family members of patients with different types of cancer. The present work aimed to evaluate T cell subsets and NK cell cytotoxic activity in 15 members of a family with high incidence of tumors, such as glioblastoma, gastric, pancreas and colon rectal carcinoma, chronic myelocitic leukemia, melanoma and osteoblastoma. As controls, 19 healthy subjects with the age range equivalent were studied. The enumeration of CD3+ lymphocytes and their CD4+ and CD8+ subsets were defined by monoclonal antibodies and NK cell cytotoxicity towards K562 target cells were evaluated by single cell-assay. The results showed in family members low percentage of total T cells (CD3+), and their CD4+ subset and impairment of CD4/CD8 ratio in relation to control group. All family members presented percentage of NK-target cell conjugate formation below the minimum value observed in control group. Thirteen people were examined and followed up during five years, in order to assure that there was no undiagnosed or unsuspected disease at the moment of evaluation. One of them developed osteoblastoma and other malignant melanoma. Two cancer patients, with glioblastoma and chronic myelocytic leukemia were studied during illness. All the corresponding values were comparable. The persistence of low percentage of conjugate formation may be related to a defect on adhesion molecules expression in the surface of NK cells that was probably responsible for the low activity of these cells presented by the family group. Thus, the inheritance mechanism of low adherence of NK cells should have a prognostic value in determining the risk of developing tumors.
Assuntos
Citotoxicidade Imunológica , Células Matadoras Naturais/imunologia , Neoplasias/imunologia , Linfócitos T Citotóxicos/imunologia , Adolescente , Adulto , Anticorpos Monoclonais/imunologia , Relação CD4-CD8 , Estudos de Casos e Controles , Moléculas de Adesão Celular/genética , Testes Imunológicos de Citotoxicidade , Feminino , Glioblastoma/genética , Glioblastoma/imunologia , Humanos , Imunidade Celular , Subpopulações de Linfócitos , Masculino , Pessoa de Meia-Idade , Neoplasias/genética , Linhagem , Estatísticas não ParamétricasRESUMO
We report a case of a carotid artery bifurcation aneurysm which ruptured into a silvian fissure arachnoid cyst. In the review of the literature, only three cases were before reported. We discuss about uncommon clinical findings, the surgical aspects and the associations among the lesions.
Assuntos
Aneurisma Roto/complicações , Cistos Aracnóideos/complicações , Aneurisma Intracraniano/complicações , Hemorragia Subaracnóidea/etiologia , Adulto , Aneurisma Roto/diagnóstico por imagem , Aneurisma Roto/cirurgia , Cistos Aracnóideos/diagnóstico por imagem , Cistos Aracnóideos/cirurgia , Angiografia Cerebral , Humanos , Aneurisma Intracraniano/diagnóstico por imagem , Aneurisma Intracraniano/cirurgia , Masculino , Tomografia Computadorizada por Raios XRESUMO
Natural killer (NK) cells play an important role in immune surveillance against tumors. The present work aimed to study the cytotoxic activity of NK cells and T cell subsets in peripheral blood of 13 patients with primary tumors in central nervous system (CNS). As controls 29 healthy subjects with the age range equivalent to the patients were studied. The methods employed were: a) determination of cytotoxic activity of NK cells towards K562 target cells, evaluated by single cell-assay; b) enumeration of CD3+ lymphocytes and their CD4+ and CD8+ subsets defined by monoclonal antibodies; c) the identification of tumors were done by histologic and immunochemistry studies. The results indicated that adults and children with tumor in CNS display reduced percentage of total T cells, helper/inducer subset and low helper/suppressor ratio. The cytotoxic activity of NK cells was decreased in patients with CNS tumors due mainly to a decrease in the proportion of target-binding lymphocytes. These results suggest that cytotoxic activity of NK cells may be affected by the immunoregulatory disturbances observed in patients with primary tumors in CNS.
Assuntos
Neoplasias do Sistema Nervoso Central/imunologia , Células Matadoras Naturais/imunologia , Subpopulações de Linfócitos T/imunologia , Adolescente , Adulto , Neoplasias do Sistema Nervoso Central/sangue , Criança , Pré-Escolar , Citotoxicidade Imunológica , Feminino , Humanos , Imunidade Celular , Masculino , Pessoa de Meia-Idade , Subpopulações de Linfócitos T/químicaRESUMO
O levantamento retrospectivo de 100 pacientes submetidos a derivacoes liquoricas subdivididos em dois grupos, 50 derivacoes ventriculo-periotoniais e 50 derivacoes ventriculo-atriais, permitiu a analise comparativa do desempenho de outros procedimentos a partir de sua indicacao nas hidrocefalias de diferentes causas suas complicacoes e as evolucoes dos pacientes