Large language models reshaping molecular biology and drug development.

The utilization of large language models (LLMs) has become a significant advancement in the domains of medicine and clinical informatics, providing a revolutionary potential for scientific breakthroughs and customized therapies. LLM models are trained on large datasets and exhibit the capacity to comprehend and analyze intricate biological data, encompassing genomic sequences, protein structures, and clinical health records. With the utilization of their comprehension of the language of biology, they possess the ability to reveal concealed patterns and insights that may evade human researchers. LLMs have been shown to positively impact various aspects of molecular biology, including the following: genomic analysis, drug development, precision medicine, biomarker development, experimental design, collaborative research, and accessibility to specialized expertise. However, it is imperative to acknowledge and tackle the obstacles and ethical implications involved. The careful consideration of data bias and generalization, data privacy and security, explainability and interpretability, and ethical concerns around responsible application is vital. The successful resolution of these obstacles will enable us to fully utilize the capabilities of LLMs, leading to substantial progress in the fields of molecular biology and pharmaceutical research. This progression also has the ability to bolster influential impacts for both the individual and the broader community.

Understanding Biases and Disparities in Radiology AI Datasets: A Review.

Artificial intelligence (AI) continues to show great potential in disease detection and diagnosis on medical imaging with increasingly high accuracy. An important component of AI model creation is dataset development for training, validation, and testing. Diverse and high-quality datasets are critical to ensure robust and unbiased AI models that maintain validity, especially in traditionally underserved populations globally. Yet publicly available datasets demonstrate problems with quality and inclusivity. In this literature review, the authors evaluate publicly available medical imaging datasets for demographic, geographic, genetic, and disease representation or lack thereof and call for an increase emphasis on dataset development to maximize the impact of AI models.