RESUMO
The next generation, superconducting electron cyclotron resonance (ECR) ion source VENUS (versatile ECR ion source for nuclear science) started operation with 28 GHz microwave heating in 2004. Since then it has produced world record ion beam intensities. For example, 2850 e microA of O(6+), 200 e microA of U(33+) or U(34+), and in respect to high charge state ions, 1 e microA of Ar(18+), 270 e microA of Ar(16+), 28 e microA of Xe(35+), and 4.9 e microA of U(47+) have been produced. A brief overview of the latest developments leading to these record intensities is given and the production of high intensity uranium beams is discussed in more detail.
Assuntos
Glicoproteínas de Membrana/análise , Mesotelioma/patologia , Pleura/patologia , Neoplasias Pleurais/patologia , Adenocarcinoma/diagnóstico , Adenocarcinoma/metabolismo , Adenocarcinoma/secundário , Anticorpos Monoclonais/imunologia , Biópsia , Neoplasias da Mama/diagnóstico , Neoplasias da Mama/metabolismo , Neoplasias da Mama/secundário , Neoplasias do Colo/diagnóstico , Neoplasias do Colo/metabolismo , Neoplasias do Colo/secundário , Diagnóstico Diferencial , Proteínas Ligadas por GPI , Humanos , Imuno-Histoquímica , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/metabolismo , Neoplasias Pulmonares/secundário , Glicoproteínas de Membrana/imunologia , Mesotelina , Mesotelioma/diagnóstico , Mesotelioma/metabolismo , Pleura/química , Neoplasias Pleurais/diagnóstico , Neoplasias Pleurais/metabolismo , Sensibilidade e EspecificidadeRESUMO
BACKGROUND: Left handedness has been associated with inflammatory bowel disease (IBD) and autoimmune diseases. AIMS: To determine whether left handedness is associated with IBD in two prospective national birth cohorts. METHODS: Subjects with Crohn's disease (CD) and ulcerative colitis (UC) were identified from two national longitudinal birth cohorts at age 26 years (1970 British Cohort Study (BCS70), born in 1970) and age 33 years (National Child Development Study (NCDS), born in 1958). Laterality was determined at age 10 (BCS70) or seven (NCDS) years, based on hand preference for writing and foot preference for kicking a ball (BCS70 only). Multiple logistic regression was used to assess the relationship of handedness with CD, UC, and IBD in the cohorts combined and adjusted for sex. RESULTS: Both cohorts combined showed increased adjusted relative odds of 2.13 (95% confidence interval (CI) 0.97--4.65; p=0.059), 2.13 (95% CI 0.92--4.91; p=0. 077), and 2.13 (95% CI 1.20--3.78; p=0.010) for CD, UC, and IBD, respectively in left handers. CONCLUSIONS: The study suggests a link between IBD and left handedness which may be genetic and/or environmental in origin.