1.
Org Biomol Chem
; 15(44): 9331-9351, 2017 Nov 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29087411
RESUMO
A new and short fragment-based approach towards artificial (but "natural-based") complex polyphenols has been developed, exploiting the Ugi multicomponent reaction of phenol-containing simple substrates. The resulting library of compounds has been tested for its capacity to inhibit ß-amyloid protein aggregation, as a possible strategy to develop new chemical entities to be used as prevention or therapy for Alzheimer's disease. Some of the members of this library have demonstrated, in thioflavin assays, a highly promising activity in inhibiting aggregation for two ß-amyloid peptides: Aß1-42 and the truncated AßpE3-42.