Associations of circulating advanced glycation end products and their soluble receptors with cancer risk: A systematic review and meta-analysis of observational studies.

Advanced glycation end products (AGE) in complex with their receptors (RAGE) cause a chronic inflammatory state in the body, which is the major mechanism in cancer development. This study aimed to conduct a systematic review and meta-analysis on the observational studies investigating the association between AGEs / sRAGE and cancer incidence. The PubMed, Scopus, and Web of Science databases were comprehensively searched to identify papers focused on the associations of sRAGE and AGEs with cancer incidence up to May 2023. Eight studies with a total of 7690 participants were included in the analysis to evaluate the association between circulating sRAGE and cancer incidence. The results indicated that circulating sRAGE (per 100 ng/L) had a significant inverse association with cancer incidence (RR 0.977; 95% CI 0.956, 0.999; p = 0.036; I 2 = 73.3%). The association between AGEs and cancer incidence was evaluated in 8 studies with a total of 3718 individuals. Serum concentrations of AGEs (per 100 µg/L) were not associated with the risk of cancer incidence (RR 0.988; 95% CI 0.974, 1.002; p = 0.08; I2 = 78.8%). Our findings revealed that a higher circulating sRAGE may have a protective effect against cancer incidence.

Effects of irrigation intervals and organic manure on morphological traits, essential oil content and yield of oregano ( Origanum vulgare L.).

In order to evaluate the effect of irrigation intervals and cattle manure levels on morphological traits, essential oil content and yield of oregano, an experiment was conducted at the experimental Farm of the Faculty of Agriculture, Urmia University, Iran. The experimental design was split-plots, arranged in randomized complete blocks with three replications. Main plots including irrigation intervals (1, 2 and 3 weeks) and four levels of cattle manure at 0, 10, 20 and 30 t ha-1 were allocated to sub plots. Our results showed that increasing irrigation intervals reduced values of all morphological traits except for proportion of stems. Also, values for stems number, plant spread, stem diameter, leaf area, fresh and dry herb yield increased by increasing cattle manure levels. On the other hand, morphological traits not influenced by interaction of treatments except for plant spread and leaf area. The highest essential oil content (2.07%) and yield (66.62 kg ha-1) obtained in highest irrigation intervals and cattle manure levels. Whereas, 1 week irrigation interval without use of cattle manure produce lowest essential oil content (1.55%). For essential oil yield, the lowest value (46.37 kg ha-1) was found in 2 weeks irrigation interval with application of 20 t ha-1 cattle manure.