Saccades and presaccadic stimulus repetition alter cortical network topology and dynamics: evidence from EEG and graph theoretical analysis.

Parietal and frontal cortex are involved in saccade generation, and their output signals modify visual signals throughout cortex. Local signals associated with these interactions are well described, but their large-scale progression and network dynamics are unknown. Here, we combined source localized electroencephalography (EEG) and graph theory analysis (GTA) to understand how saccades and presaccadic visual stimuli interactively alter cortical network dynamics in humans. Twenty-one participants viewed 1-3 vertical/horizontal grids, followed by grid with the opposite orientation just before a horizontal saccade or continued fixation. EEG signals from the presaccadic interval (or equivalent fixation period) were used for analysis. Source localization-through-time revealed a rapid frontoparietal progression of presaccadic motor signals and stimulus-motor interactions, with additional band-specific modulations in several frontoparietal regions. GTA analysis revealed a saccade-specific functional network with major hubs in inferior parietal cortex (alpha) and the frontal eye fields (beta), and major saccade-repetition interactions in left prefrontal (theta) and supramarginal gyrus (gamma). This network showed enhanced segregation, integration, synchronization, and complexity (compared with fixation), whereas stimulus repetition interactions reduced synchronization and complexity. These cortical results demonstrate a widespread influence of saccades on both regional and network dynamics, likely responsible for both the motor and perceptual aspects of saccades.

Integration of structural brain networks is related to openness to experience: A diffusion MRI study with CSD-based tractography.

Openness to experience is one of the big five traits of personality which recently has been the subject of several studies in neuroscience due to its importance in understanding various cognitive functions. However, the neural basis of openness to experience is still unclear. Previous studies have found largely heterogeneous results, suggesting that various brain regions may be involved in openness to experience. Here we suggested that performing structural connectome analysis may shed light on the neural underpinnings of openness to experience as it provides a more comprehensive look at the brain regions that are involved in this trait. Hence, we investigated the involvement of brain network structural features in openness to experience which has not yet been explored to date. The magnetic resonance imaging (MRI) data along with the openness to experience trait score from the self-reported NEO Five-Factor Inventory of 100 healthy subjects were evaluated from Human Connectome Project (HCP). CSD-based whole-brain probabilistic tractography was performed using diffusion-weighted images as well as segmented T1-weighted images to create an adjacency matrix for each subject. Using graph theoretical analysis, we computed global efficiency (GE) and clustering coefficient (CC) which are measures of two important aspects of network organization in the brain: functional integration and functional segregation respectively. Results revealed a significant negative correlation between GE and openness to experience which means that the higher capacity of the brain in combining information from different regions may be related to lower openness to experience.

Linear vector models of time perception account for saccade and stimulus novelty interactions.

Various models (e.g., scalar, state-dependent network, and vector models) have been proposed to explain the global aspects of time perception, but they have not been tested against specific visual phenomena like perisaccadic time compression and novel stimulus time dilation. Here, in two separate experiments (N = 31), we tested how the perceived duration of a novel stimulus is influenced by 1) a simultaneous saccade, in combination with 2) a prior series of repeated stimuli in human participants. This yielded a novel behavioral interaction: pre-saccadic stimulus repetition neutralizes perisaccadic time compression. We then tested these results against simulations of the above models. Our data yielded low correlations against scalar model simulations, high but non-specific correlations for our feedforward neural network, and correlations that were both high and specific for a vector model based on identity of objective and subjective time. These results demonstrate the power of global time perception models in explaining disparate empirical phenomena and suggest that subjective time has a similar essence to time's physical vector.

The longitudinal relationship between BOLD signal variability changes and white matter maturation during early childhood.

Intra-individual transient temporal fluctuations in brain signal, as measured by fMRI blood oxygenation level dependent (BOLD) variability, is increasingly considered an important signal rather than measurement noise. Evidence from computational and cognitive neuroscience suggests that signal variability is a good proxy-measure of brain functional integrity and information processing capacity. Here, we sought to explore across-participant and longitudinal relationships between BOLD variability, age, and white matter structure in early childhood. We measured standard deviation of BOLD signal, total white matter volume, global fractional anisotropy (FA) and mean diffusivity (MD) during passive movie viewing in a sample of healthy children (aged 2-8 years; N = 83). We investigated how age and white matter development related to changes in BOLD variability both across- and within-participants. Our across-participant analyses using behavioural partial least squares (bPLS) revealed that the influence of age and white matter maturation on BOLD variability was highly interrelated. BOLD variability increased in widespread frontal, temporal and parietal regions, and decreased in the hippocampus and parahippocampal gyrus with age and white matter development. Our longitudinal analyses using linear mixed effects modelling revealed significant associations between BOLD variability, age and white matter microstructure. Analyses using artificial neural networks demonstrated that BOLD variability and white matter micro and macro-structure at earlier ages were strong predictors of BOLD variability at later ages. By characterizing the across-participant and longitudinal features of the association between BOLD variability and white matter micro- and macrostructure in early childhood, our results provide a novel perspective to understand structure-function relationships in the developing brain.