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OBJECTIVE: The diagnosis of primary SjÓ§gren's syndrome still relies upon a constellation of clinical, laboratory, imaging, and pathological findings. We aimed to evaluate the relation of the disease activity with the results of diagnostic tests for primary SjÓ§gren's syndrome. METHODS: A principal component with cluster analysis was performed to classify 69 patients with primary SjÓ§gren's syndrome based on the results of diagnostic evaluations. RESULTS: Anti-SSA autoantibody was the most represented feature on the principal components. The anti-SSA and ultrasound score were positively correlated (p=0.001). We identified two distinct clusters of low or high disease activity (p<0.001). Except for disease duration and serum beta2-microglobulin, the clusters were significantly different in salivary flow (p= 0.004), ultrasound findings (p<0.001), IgG (p= 0.001), and salivary beta2-microglobulin (p= 0.048). Also, positive findings were significantly different between the clusters in rheumatoid factor, antinuclear antibody, anti-SSA, and anti-SSB (all p≤0.013). CONCLUSION: Patients with higher syndrome activity were best recognized with serological and ultrasound assessments. However, patients with lower syndrome activity had a longer disease duration, higher stimulated salivary flow rate, and a positive biopsy of minor salivary glands (56%).
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Síndrome de Sjogren , Humanos , Síndrome de Sjogren/diagnóstico , Síndrome de Sjogren/patologia , Autoanticorpos , Anticorpos Antinucleares , Fator Reumatoide , Análise por ConglomeradosRESUMO
INTRODUCTION AND OBJECTIVES: Allergic asthma is a chronic inflammatory disorder of the airways. Th1, Th2 and Th17 cells are the main cells involved in the pathophysiology of asthma. The function of these cells is affected by T-bet, GATA3 and RORγt transcription factors (respectively). Therefore, the aim of this study was to evaluate the effect of ginger (officinal Roscoe) extract on the expression of T-bet, GATA-3 and ROR-γ in peripheral blood mononuclear cells (PBMC) of asthmatic patients, in comparison with healthy volunteers as controls. MATERIALS AND METHODS: In this case-control study, a total of 50 individuals including 25 patients with severe, moderate and mild allergic asthma and 25 unrelated healthy controls were involved. The PBMCs were isolated and divided into four groups: negative control, two positive controls (Budesonide and PHA) and ginger-extract treated group. After cell treatment and incubation for 48h, PBMCs were isolated and cDNA was synthesized. Gene expressions of T-bet, GATA3 and ROR-γt were evaluated by Real-time PCR. RESULTS: According to the results of this study, hydroalcoholic extract of ginger could reduce the expression of GATA-3, ROR-γt, and T-bet in PBMCs of asthmatic patients in comparison with untreated PBMCs (P values=0.001, 0.001, and 0.002, respectively). It was also shown that the ginger extract could affect T-bet/GATA-3, T-bet/ROR-γt, and ROR-γt/GATA-3 expression ratios. CONCLUSIONS: This study showed that the use of ginger extract could control asthma and decrease the severity of this disease by affecting the main cells involving the symptoms of asthma in the airways.
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Antiasmáticos/farmacologia , Asma/tratamento farmacológico , Fator de Transcrição GATA3/metabolismo , Hipersensibilidade/tratamento farmacológico , Leucócitos Mononucleares/fisiologia , Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares/metabolismo , Extratos Vegetais/farmacologia , Proteínas com Domínio T/metabolismo , Adolescente , Adulto , Estudos de Casos e Controles , Células Cultivadas , Criança , Fator de Transcrição GATA3/genética , Regulação da Expressão Gênica , Zingiber officinale/imunologia , Humanos , Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares/genética , Proteínas com Domínio T/genética , Adulto JovemRESUMO
Although surgery is traditionally the standard of care for esophageal cancer, esophagectomy carries significant morbidity. Alternative endoscopic therapies are needed for patients who are not candidates for conventional treatment. The objective of this study is to assess the safety, efficacy, and tolerability of spray cryotherapy of esophageal adenocarcinoma. This study includes patients with esophageal adenocarcinoma who had failed or were not candidates for conventional therapy enrolled retrospectively and prospectively in an open-label registry and patients in a retrospective cohort from 11 academic and community practices. Endoscopic spray cryotherapy was performed until biopsy proven local tumor eradication or until treatment was halted due to progression of disease, patient withdrawal or comorbidities. Eighty-eight patients with esophageal adenocarcinoma (median age 76, 80.7% male, mean length 5.1 cm) underwent 359 treatments (mean 4.4 per patient). Tumor stages included 39 with T1a, 25 with T1b, 9 with unspecified T1, and 15 with T2. Eighty-six patients completed treatment with complete response of intraluminal disease in 55.8%, including complete response in 76.3% for T1a, 45.8% for T1b, 66.2% for all T1, and 6.7% for T2. Mean follow-up was 18.4 months. There were no deaths or perforations related to spray cryotherapy. Strictures developed in 12 of 88 patients (13.6%) but were present before spray cryotherapy in 3 of 12. This study suggests that endoscopic spray cryotherapy is a safe, well-tolerated, and effective treatment option for early esophageal adenocarcinoma.
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Adenocarcinoma/cirurgia , Crioterapia/métodos , Neoplasias Esofágicas/cirurgia , Esofagoscopia/métodos , Adenocarcinoma/patologia , Idoso , Idoso de 80 Anos ou mais , Biópsia , Neoplasias Esofágicas/patologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Estudos Retrospectivos , Resultado do TratamentoRESUMO
PURPOSE: The purpose of this study was to investigate the effect of observing point-light and video models and physical practice on learning a crouch start. METHOD: Thirty-two female students were randomly assigned into point-light, video, physical practice, and control groups. They performed 10 trials in pretest, 160 trials in acquisition phase, and 10 trials in 24-hour retention test. Kinematic features and reaction time were measured as dependent variables. RESULTS: Results showed that physical practice group performed better than other groups in reaction time and range of motion of trunk and observational groups performed better than control groups in reaction time and range of motion of knee. CONCLUSION: The results confirm the positive effects of observational practice on motor learning.
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Aprendizagem/fisiologia , Destreza Motora/fisiologia , Prática Psicológica , Tempo de Reação/fisiologia , Adolescente , Fenômenos Biomecânicos/fisiologia , Feminino , Humanos , Retenção Psicológica , Adulto JovemRESUMO
Retrospective series have shown the efficacy of endoscopic spray cryotherapy in eradicating high-grade dysplasia (HGD) in Barrett's esophagus (BE); however, prospective data are lacking, and efficacy for low-grade dysplasia (LGD) is unclear. The aim of this study was to assess the efficacy and safety of spray cryotherapy in patients with LGD or HGD. A multicenter, prospective open-label registry enrolled patients with dysplastic BE. Spray cryotherapy was performed every 2-3 months until there was no endoscopic evidence of BE and no histological evidence of dysplasia, followed by surveillance endoscopies up to 2 years. Primary outcome measures were complete eradication of dysplasia (CE-D) and complete eradication of all intestinal metaplasia (CE-IM). Ninety-six subjects with Barrett's dysplasia (67% HGD; 65% long-segment BE; mean length 4.5 cm) underwent 321 treatments (mean 3.3 per subject). Mean age was 67 years, 83% were male. Eighty patients (83%) completed treatment with follow-up endoscopy (mean duration 21 months). In patients with LGD, rate of CE-D was 91% (21/23) and rate of CE-IM was 61% (14/23). In HGD, CE-D rate was 81% (46/57) and CE-IM was 65% (37/57). In patients with short-segment BE (SSBE) with any dysplasia, CE-D was achieved in 97% (30/31) and CE-IM in 77% (24/31). There were no esophageal perforations or related deaths. One subject developed a stricture, which did not require dilation. One patient was hospitalized for bleeding in the setting of non-steroidal anti-inflammatory drug use. In the largest prospective cohort to date, data suggest endoscopic spray cryotherapy is a safe and effective modality for eradication of BE with LGD or HGD, particularly with SSBE.
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Esôfago de Barrett/cirurgia , Crioterapia/métodos , Esofagoscopia/métodos , Idoso , Idoso de 80 Anos ou mais , Ablação por Cateter/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Nitrogênio/administração & dosagem , Nitrogênio/química , Estudos Prospectivos , Sistema de Registros , Resultado do TratamentoRESUMO
Tremendous efforts towards improvement in the critical current density "Jc" of iron based superconductors (FeSCs), especially at relatively low temperatures and magnetic fields, have been made so far through different methods, resulting in real progress. Jc at high temperatures in high fields still needs to be further improved, however, in order to meet the requirements of practical applications. Here, we demonstrate a simple approach to achieve this. Hydrostatic pressure can significantly enhance Jc in NaFe0.97Co0.03As single crystals by at least tenfold at low field and more than a hundredfold at high fields. Significant enhancement in the in-field performance of NaFe0.97Co0.03As single crystal in terms of pinning force density (Fp) is found at high pressures. At high fields, the Fp is over 20 and 80 times higher than under ambient pressure at12 K and 14 K, respectively, at P = 1 GPa. We believe that the Co-doped NaFeAs compounds are very exciting and deserve to be more intensively investigated. Finally, it is worthwhile to say that by using hydrostatic pressure, we can achieve more milestones in terms of high Jc values in tapes, wires or films of other Fe-based superconductors.
RESUMO
Pressure is well known to significantly raise the superconducting transition temperature, Tc, in both iron pnictides and cuprate based superconductors. Little work has been done, however, on how pressure can affect the flux pinning and critical current density in the Fe-based superconductors. Here, we propose to use hydrostatic pressure to significantly enhance flux pinning and Tc in polycrystalline pnictide bulks. We have chosen Sr4V2O6Fe2As2 polycrystalline samples as a case study. We demonstrate that the hydrostatic pressure up to 1.2â GPa can not only significantly increase Tc from 15â K (underdoped) to 22â K, but also significantly enhance the irreversibility field, Hirr, by a factor of 4 at 7â K, as well as the critical current density, Jc, by up to 30 times at both low and high fields. It was found that pressure can induce more point defects, which are mainly responsible for the Jc enhancement. Our findings provide an effective method to significantly enhance Tc, Jc, Hirr, and the upper critical field, Hc2, for other families of Fe-based superconductors in the forms of wires/tapes, films, and single crystal and polycrystalline bulks.
RESUMO
BACKGROUND: Gastric cancer is a forth common malignancy world-wide and the second most common cause of cancer-related deaths. According to the current International Union Against Cancer staging system, nodal status is categorized based on the number of metastatic lymph nodes (LNs). Some groups have recently proposed the metastatic lymph node ratio (MLR) (the ratio between metastatic LNs and total dissected LNs; MLR) as an alternative prognostic factor. The aim of the present study is to evaluate the relationship between MLR and different clinico pathologic factors including patients' age, tumor grade, stage, sites of involvement and disease prognosis. METHODS: Atotal of 70 patients with gastric adenocarcinoma who underwent gastrectomy with negative margin and LN resection during 2004-2009 and were referred to Radiotherapy-Oncology Department of Name of Hospital, Name of City, were included in the study. MLR status was divided to five groups. Collected data were analyzed with SPSS 16 (SPSS Inc., Chicago, IL, USA). RESULTS: The difference between MLR groups in age was significant; older patients had lower MLR (P = 0.01). The ratio of male to female was 5.3, which indicated higher prevalence of gastric cancer in males. The difference between MLR groups for tumor location, tumor stage, disease free periods and tumor T stages were not significant. A significant relation existed between different stages of LN involvement and MLR; and also between cancer stages and MLR. CONCLUSION: We found a significant relation between MLR and cancer stage and metastatic LN. Due to small sample size and short period of follow-up, we could not find significant relation between MLR and other factors such as depth of tumor invasion, disease free period and tumor grading. In conclusion with regards to our results and other similar studies' results, we acknowledge the importance of MLR in determining patients' prognosis in gastric cancer.
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Linfonodos/patologia , Metástase Linfática/patologia , Neoplasias Gástricas/patologia , Idoso , Estudos Transversais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estadiamento de Neoplasias/métodosRESUMO
AIM: The first aim of this study was to compare the VO2at lactate threshold (LT) and maximum rate of fat oxidation (Fat(max)) intensity in wrestlers. A secondary aim was to compare the different recovery trials in wrestlers for finding effective methods of lactate removal post-match. METHODS: Eight wrestlers (mean ± SD; age, 23.2 ± 1 year; VO(2max), 55.2 ± 3.4 mL.min⻹.kg⻹) completed four recovery trials in a counter-balanced order. Maximal oxygen uptake (VO(2max)), Fat(max), individual anaerobic threshold (IAT), individual ventilatory threshold (IVT), and LT were determined during a graded exercise test. Different recovery methods were performed at a similar time of the day after three 2 min wrestling match. Lactate concentration was obtained at rest, and at 0, 5, 10, 15 and 20 min of post-match. RESULTS: In wrestler, Fat(max) was significantly correlated with LT (r=0.47, P<0.05) and lactate concentration (mean ± SD) significantly increased during the match from (1.7 ± 0.2 mmol.L⻹) to (15.1 ± 1.3 mmol.L⻹). At 5 minute, IVT method provides greater reduce in blood lactate (79% ∆La) and in other time point (10, 15 and 20 min) Fat(max) intensity provides more reduce. CONCLUSION: Fat(max) intensity is the most effective method for removal lactate concentration in wrestlers. There may be a relationship between improve in endurance capacity and training at the Fat(max) intensity.
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Ácido Láctico/sangue , Recuperação de Função Fisiológica , Luta Romana , Limiar Anaeróbio , Humanos , Metabolismo dos Lipídeos , Masculino , Consumo de Oxigênio , Adulto JovemRESUMO
OBJECTIVES: To evaluate anti-proliferative as well as apoptotic activities of compounds identified in chloroform extract of Juglans regia leaves, on human breast and oral cancer cell lines (MCF-7 and BHY). MATERIALS AND METHODS: Column chromatography, MTT assay, flowcytometry and western blotting have all been used in the study. RESULTS: Bioassay-guided fractionation of chloroform extract of J. regia afforded isolation of 5-hydroxy-3,7,4'-trimethoxyflavone [1], lupeol [2], daucosterol [3], 4-hydroxy-α-tetralone [4], ß-sitosterol [5], 5,7- dihydroxy-3,4'-dimethoxyflavone [6] and regiolone [7]. Structures of the compounds were established on the basis of spectroscopic analyses [Nuclear magnetic resonance (NMR) and mass]. All compounds inhibited proliferation of MCF-7 (human breast adenocarcinoma) and BHY (human oral squamous carcinoma) cells in a concentration-dependent manner. Compounds 6 and 7 had potent cytotoxic effects on both MCF-7 and BHY cells (IC50 21-51 µm), yet were not toxic to normal cells. MCF-7 growth inhibition was attributed to apoptosis; population of apoptotic cells increased from 1.12% in controls to 5.64 and 8.1% after 48-h treatment with compounds 6 and 7, indicating their potential at inducing early and late apoptosis. The caspase cascade was not activated, as indicated by only insignificant cleavage of caspase-3. CONCLUSIONS: Our results suggest that compounds 6 and 7 can induce apoptosis in MCF-7 cells through the caspase-3 independent pathway.
Assuntos
Antineoplásicos Fitogênicos/farmacologia , Apoptose/efeitos dos fármacos , Proliferação de Células/efeitos dos fármacos , Juglans , Adenocarcinoma/tratamento farmacológico , Adenocarcinoma/enzimologia , Adenocarcinoma/patologia , Antineoplásicos Fitogênicos/química , Neoplasias da Mama/tratamento farmacológico , Neoplasias da Mama/enzimologia , Neoplasias da Mama/patologia , Carcinoma de Células Escamosas/tratamento farmacológico , Carcinoma de Células Escamosas/enzimologia , Carcinoma de Células Escamosas/patologia , Caspase 3/metabolismo , Linhagem Celular Tumoral , Clorofórmio , Feminino , Flavonas/química , Flavonas/farmacologia , Humanos , Juglans/química , Células MCF-7 , Neoplasias Bucais/tratamento farmacológico , Neoplasias Bucais/enzimologia , Neoplasias Bucais/patologia , Fitoterapia , Extratos Vegetais/química , Extratos Vegetais/farmacologia , Folhas de Planta/química , Transdução de Sinais/efeitos dos fármacosRESUMO
In order to evaluate the reaction of yield and yield components of wheat's mutant lines to different levels of nitrogen in the crop year of 2006-2007, an experiment was conducted as factorial based on completely randomized block design in 4 replicates in the Research Farm of Agricultural, Medical and Industrial Research School in Zaferaniyeh-Karaj-Iran the first factor included 5 genotypes of wheat (Tabasi-the maternal entity, T-65-7-1, T-65-5-1, T-6-67-60, T-65-58-8) and the second factor consisted of 4 levels of nitrogen (100, 140, 180 and 220 kg ha(-1) urea 46%). The result showed that grain's yield harvest index, number of grain/spike in mutant lines and their parent had significant difference (p < 0.01) in mutant genotypes, meanwhile, the biological yield and the number of spike m2 were not significant difference (p < 0.05). The harvest index, number of grains per spike, grain's yield, biologic yield and number of spikes m(-2), weight of 1000 grains didn't affected by applying different levels of nitrogen fertilizer.
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Fertilizantes , Mutação , Nitrogênio/metabolismo , Triticum/genética , Agricultura/métodos , Produtos Agrícolas/anatomia & histologia , Produtos Agrícolas/genética , Grão Comestível/genética , Fertilização , Genes de Plantas , Genótipo , Fenótipo , Triticum/fisiologiaRESUMO
To study the cross interaction of microorganisms in plant growth promotion and the effect of auxin in this interaction, Pseudomonas putida and Glomus intraradices were co-inoculated on wheat. For this purpose, a mutant that produced less amount of auxin was derived from the bacterial strain by chemical mutagenesis with ethyl methane sulfonate. Next both the wild-type strain and the mutant strain were labeled with gusA for a better detection on the roots. Finally, the bacteria were inoculated on wheat as single inoculants or combined with arbuscular mycorrhizal fungi. Controls included non-bacteria/non-arbuscular mycorrhizal fungi and arbuscular mycorrhizal fungi alone. Plants co-inoculated with the wild-type bacterial strain and Glomus intraradices had the highest stem and their fresh and dry shoot weight was more than other treatments. Also, it was observed that the wild-type strain significantly improved the mycorrhizal colonization which implies the beneficial effect of auxin on mycorrhizal colonization. Furthermore, Glomus intraradices increased the population density of the wild-type strain in the endorhizosphere. In the microscopic studies of plant roots, bacterial colonies were observed as blues lines on the surface and inside the roots as well as on the seed surfaces.
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Micorrizas/fisiologia , Raízes de Plantas/microbiologia , Pseudomonas putida/fisiologia , Triticum/microbiologia , Micorrizas/crescimento & desenvolvimento , Raízes de Plantas/crescimento & desenvolvimento , Pseudomonas putida/crescimento & desenvolvimento , Sementes/crescimento & desenvolvimento , Sementes/microbiologia , Triticum/crescimento & desenvolvimentoRESUMO
During 2006-2007 growing seasons, survey were carried to identify a virus disease causing mosaic of soybean in the field in Southern region (Khozestan Province) of Iran. To detect the viral infection, diseased leaf samples showing mild mosaic and leaf malformation were collected from soybean fields in Dezful, located in Khozestan Province. Infected samples were carried to the lab in a proper condition on ice packages. TPIA and DAS-ELISA serological tests were applied to identify the viral agent. To investigate the host-range, several indicator plants were mechanically inoculated under green-house condition. Seed transmission of CPMMV was examined using the seeds obtained from infected plants. The virus isolate was not found to be seed-borne in Clark variety of soybean. Different steps of ultracentrifugation including sucrose density gradient (10-40%) were carried out in order to obtain partial purified virus. On the basis of biological, serological and EM results, CPMMV-Carla virus was identified in the infected soybean samples. This is the first report of CPMMV infection of soybean in Iran.
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Carlavirus/isolamento & purificação , Carlavirus/patogenicidade , Glycine max/virologia , Doenças das Plantas/virologia , Carlavirus/classificação , Carlavirus/ultraestrutura , Ensaio de Imunoadsorção Enzimática , Geografia , Irã (Geográfico) , Folhas de Planta/virologia , Estações do Ano , Sorotipagem , Manejo de EspécimesRESUMO
1. Genetic parameters were estimated in a base population of a closed experimental strain of fowl. Data were obtained on 21 245 Iranian native hens (breeding centre for Fars province) subject to 8 successive generations of selection. This population had been selected for body weight at 12 weeks of age (BW12) and egg number during the first 12 weeks of the laying period (EN), mean egg weight (EW) at weeks 28, 30 and 32, and age at sexual maturity (ASM). 2. The method of multi-traits restricted maximum likelihood with an animal model was used to estimate genetic parameters. Resulting heritabilities for BW12, EN, EW and ASM were 0.68 +/- 0.02, 0.40 +/- 0.02, 0.64 +/- 0.02 and 0.49 +/- 0.02, respectively. 3. Genetic correlations between BW12 and EN, EW and ASM were 0.11 +/- 0.33, 0.54 +/- 0.21 and -0.12 +/- 0.03, respectively. Genetic correlations between EN and EW and ASM were -0.09 +/- 0.03 and -0.85 +/- 0.01, respectively, while between EW and ASM, it was 0.05 +/- 0.03. 4. The overall predicted genetic gains, after 7 generations of selection, estimated by the regression coefficients of the breeding value on generation number were equal to 22.7, 0.17, 0.04 and -1.38, for BW12, EN, EW and ASM, respectively. 5. A pedigree file of 21 245 female and male birds was used to calculate inbreeding coefficients and their influence on production and reproduction traits. Average inbreeding coefficients for all birds, inbred birds, female birds and male birds were 0.048, 0.673, 0.055 and 0.047%, respectively. Regression coefficients of BW12, ASM, EN and EW on inbreeding coefficient for all birds were equal to 0.51 +/- 0.001, 0.31 +/- 0.003, -0.51 +/- 0.003 and 0.03 +/- 0.001, respectively.
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Galinhas/genética , Endogamia , Animais , Peso Corporal/genética , Galinhas/anatomia & histologia , Galinhas/crescimento & desenvolvimento , Tamanho da Ninhada/genética , Feminino , Irã (Geográfico) , Funções Verossimilhança , Masculino , Óvulo/crescimento & desenvolvimento , Linhagem , Fenótipo , Análise de RegressãoRESUMO
Genetic parameters were estimated in base population of a closed experimental strain fowl, from data issued from 13 successive generations of selection. This population had been selected for body weight at 12 weeks of age (BW12) and egg number during the first 12 weeks of laying period (EN), mean egg weight at 28th, 30th, 32nd weeks and Age at Sexual Maturity (ASM). Data were obtained on 35461 Iranian native hens belonging to breeding center for Fars province in Iran. The method of multi-traits restricted maximum likelihood with an animal model was used to estimate genetic parameters. Resulting heritabilities for BW12, EN, EW and ASM were 0.58, 0.34, 0.62 and 0.49, respectively. Genetic correlations between BW12 and EN, EW and ASM were -0.06, 0.49 and 0.02, respectively. Genetic correlations between EN and EW and ASM were -0.26 and-0.77, respectively, while between EW and ASM, it was 0.20. The overall predicted genetic gains, after 13 generations of selection, estimated by the regression coefficients of the breeding value on generation number were equal to 9.55, 0.99, 0.05 and -1.66, for BW12, EN, EW and ASM, respectively.
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Galinhas/genética , Criação de Animais Domésticos/economia , Animais , Peso Corporal , Galinhas/fisiologia , Feminino , Variação Genética , Genética Populacional , Irã (Geográfico) , Funções Verossimilhança , Masculino , Modelos Genéticos , Modelos Estatísticos , Análise de Regressão , Fatores de TempoRESUMO
Religion can be an important resource for people struggling with chronic illness. Problem-solving skills have also been shown to be helpful. This study examined whether turning to religion as a coping resource would be associated with better problem-solving in couples trying to manage challenges associated with prostate cancer. The sample was 101 patients with prostate cancer and their wives. Wives completed the Social Problem-Solving Inventory--Revised at baseline (T1) and 10 weeks later (T2). Patients and their wives also completed a measure that included items on religious coping. These items were used to classify couples into four groups based on whether one or both members engaged in religious coping: (1) husband only, (2) wife only, (3) both husband and wife, and (4) neither husband nor wife. From T1 to T2, wives who used religious coping along with their husbands (group 3) showed a significantly greater reduction in dysfunctional problem-solving (specifically, on impulsive/careless problem-solving) in comparison with wives who used religious coping while their husbands did not (group 2). Findings suggest that when couples share in turning to religion as a source of coping, this may be associated with improved problem-solving, but sole engagement in religious coping by wives may be associated with worse problem-solving.