1.
Bioorg Med Chem Lett
; 18(14): 4242-8, 2008 Jul 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18547806
RESUMO
Checkpoint kinase-1 (Chk1, CHEK1) is a Ser/Thr protein kinase that mediates the cellular response to DNA-damage. A novel class of 2-ureido thiophene carboxamide urea (TCU) Chk1 inhibitors is described. Inhibitors in this chemotype were optimized for cellular potency and selectivity over Cdk1.