Full Classification of Transport on an Equilibrated 5/2 Edge via Shot Noise.

The nature of the bulk topological order of the 5/2 non-Abelian fractional quantum Hall state and the steady state of its edge are long-studied questions. The most promising non-Abelian model bulk states are the Pfaffian (Pf), anti-Pffafian (APf), and particle-hole symmetric Pfaffian (PHPf). Here, we propose to employ a set of dc current-current correlations (electrical shot noise) in order to distinguish among the Pf, APf, and PHPf candidate states, as well as to determine their edge thermal equilibration regimes: full vs partial. Using other tools, measurements of GaAs platforms have already indicated consistency with the PHPf state. Our protocol, realizable with available experimental tools, is based on fully electrical measurements.

Manipulating Non-Abelian Anyons in a Chiral Multichannel Kondo Model.

Non-Abelian anyons are fractional excitations of gapped topological models believed to describe certain topological superconductors or quantum Hall states. Here, we provide the first numerical evidence that they emerge as independent entities also in gapless electronic models. Starting from a multi-impurity multichannel chiral Kondo model, we introduce a novel mapping to a single-impurity model, amenable to Wilson's numerical renormalization group. We extract its spectral degeneracy structure and fractional entropy, and calculate the F matrices, which encode the topological information regarding braiding of anyons, directly from impurity spin-spin correlations. Impressive recent advances on realizing multichannel Kondo systems with chiral edges may thus bring anyons into reality sooner than expected.

Cumulative polarization in conductive interfacial ferroelectrics.

Ferroelectricity in atomically thin bilayer structures has been recently predicted1 and measured2-4 in two-dimensional materials with hexagonal non-centrosymmetric unit-cells. The crystal symmetry translates lateral shifts between parallel two-dimensional layers to sign changes in their out-of-plane electric polarization, a mechanism termed 'slide-tronics'4. These observations have been restricted to switching between only two polarization states under low charge carrier densities5-12, limiting the practical application of the revealed phenomena13. To overcome these issues, one should explore the nature of polarization in multi-layered van der Waals stacks, how it is governed by intra- and interlayer charge redistribution and to what extent it survives the addition of mobile charge carriers14. To explore these questions, we conduct surface potential measurements of parallel WSe2 and MoS2 multi-layers with aligned and anti-aligned configurations of the polar interfaces. We find evenly spaced, nearly decoupled potential steps, indicating highly confined interfacial electric fields that provide a means to design multi-state 'ladder-ferroelectrics'. Furthermore, we find that the internal polarization remains notable on electrostatic doping of mobile charge carrier densities as high as 1013 cm-2, with substantial in-plane conductivity. Using density functional theory calculations, we trace the extra charge redistribution in real and momentum spaces and identify an eventual doping-induced depolarization mechanism.

Emergence of Neutral Modes in Laughlin-like Fractional Quantum Hall Phases.

Chiral gapless boundary modes are characteristic of quantum Hall (QH) states. For hole-conjugate fractional QH phases counterpropagating edge modes (upstream and downstream) are expected. In the presence of electrostatic interactions and disorder these modes may renormalize into charge and upstream neutral modes. Orthodox models of Laughlin phases anticipate only a downstream charge mode. Here we show that in the latter case, in the presence of a smooth confining potential, edge reconstruction leads to the emergence of pairs of counterpropagating modes, which, by way of mode renormalization, may give rise to nontopological upstream neutral modes, possessing nontrivial statistics. This may explain the experimental observation of ubiquitous neutral modes, and the overwhelming suppression of anyonic interference in Mach-Zehnder interferometry platforms. We also point out other signatures of such edge reconstruction.

Photon-Instanton Collider Implemented by a Superconducting Circuit.

Instantons, spacetime-localized quantum field tunneling events, are ubiquitous in correlated condensed matter and high-energy systems. However, their direct observation through collisions with conventional particles has not been considered possible. We show how recent advances in circuit quantum electrodynamics, specifically, the realization of galvanic coupling of a transmon qubit to a high-impedance transmission line, allows the observation of inelastic collisions of single microwave photons with instantons (phase slips). We develop a formalism for calculating the photon-instanton cross section, which should be useful in other quantum field theoretical contexts. In particular, we show that the inelastic scattering probability can significantly exceed the effect of conventional Josephson quartic anharmonicity and reach order-unity values.

The efficacy of pocket elimination/reduction compared to access flap surgery: A systematic review and meta-analysis.

AIM: To assess the efficacy and adverse effects of resective surgery compared to access flap in patients with periodontitis. METHODS: Randomized controlled trials with a follow-up ≥6 months were identified in ten databases. Screening, data extraction, and quality assessment were conducted by two reviewers. The primary outcome was probing pocket depth, and the main secondary outcome was clinical attachment level. Data on adverse events were collected. Meta-analysis was used to synthesize the findings of trials. RESULTS: A total of 880 publications were identified. Fourteen publications from nine clinical trials met the inclusion criteria and were included for analysis. Meta-analysis was carried out using all available results. The results indicated superior pocket depth reduction following resective surgery compared to access flap after 6-12 months of follow-up (weighted mean difference 0.47 mm; confidence interval 0.7-0.24; p = .010). After 36-60 months of follow-up, no differences were found between the two treatments in pocket depth and attachment level. The prevalence of adverse effects was not different between the groups. Post-operative recession tended to be more severe for the resective approaches. CONCLUSION: Resective surgical approach was superior to access flap in reducing pocket depth 6-12 months post-surgery, while no differences between the two modalities were found at 36-60 months of follow-up.

Unrestricted Electron Bunching at the Helical Edge.

A quantum magnetic impurity of spin S at the edge of a two-dimensional time reversal invariant topological insulator may give rise to backscattering. We study here the shot noise associated with the backscattering current for arbitrary S. Our full analytical solution reveals that for S>1/2 the Fano factor may be arbitrarily large, reflecting bunching of large batches of electrons. By contrast, we rigorously prove that for S=1/2 the Fano factor is bounded between 1 and 2, generalizing earlier studies.

Symmetry and Correlation Effects on Band Structure Explain the Anomalous Transport Properties of (111) LaAlO_{3}/SrTiO_{3}.

The interface between the two insulating oxides SrTiO_{3} and LaAlO_{3} gives rise to a two-dimensional electron system with intriguing transport phenomena, including superconductivity, which are controllable by a gate. Previous measurements on the (001) interface have shown that the superconducting critical temperature, the Hall density, and the frequency of quantum oscillations, vary nonmonotonically and in a correlated fashion with the gate voltage. In this Letter we experimentally demonstrate that the (111) interface features a qualitatively distinct behavior, in which the frequency of Shubnikov-de Haas oscillations changes monotonically, while the variation of other properties is nonmonotonic albeit uncorrelated. We develop a theoretical model, incorporating the different symmetries of these interfaces as well as electronic-correlation-induced band competition. We show that the latter dominates at (001), leading to similar nonmonotonicity in all observables, while the former is more important at (111), giving rise to highly curved Fermi contours, and accounting for all its anomalous transport measurements.

Dissipative and Hall Viscosity of a Disordered 2D Electron Gas.

Hydrodynamic charge transport is at the center of recent research efforts. Of particular interest is the nondissipative Hall viscosity, which conveys topological information in clean gapped systems. The prevalence of disorder in the real world calls for a study of its effect on viscosity. Here we address this question, both analytically and numerically, in the context of disordered noninteracting 2D electrons. Analytically, we employ the self-consistent Born approximation, explicitly taking into account the modification of the single-particle density of states and the elastic transport time due to the Landau quantization. The reported results interpolate smoothly between the limiting cases of a weak (strong) magnetic field and strong (weak) disorder. In the regime of a weak magnetic field our results describe the quantum (Shubnikov-de Haas type) oscillations of the dissipative and Hall viscosity. For strong magnetic fields we characterize the effects of the disorder-induced broadening of the Landau levels on the viscosity coefficients. This is supplemented by numerical calculations for a few filled Landau levels. Our results show that the Hall viscosity is surprisingly robust to disorder.

Conformers of Ubiquitin 6+ for Different Charge Distributions: Atomistic Structures and Ion Mobility Cross Sections.

Despite the fact that protein chemistry occurs in solution, studying the structure of desolvated proteins in mass spectrometry vacuum conditions allows one to study biological molecules in complete isolation. The electrospray ionization process results in charged protein conformers for which the charge locations distribution and the corresponding structure are not known. In this paper, we explore the influence of different charge distributions on the structure of conformers of ubiquitin 6+ in the vacuum conditions of mass spectrometry. Using the Tinker implementation of the AMBER99FF force field, the atomistic lowest-energy structures for those charge distributions were calculated by the DEEPSAM algorithm. Differences among the calculated structures are analyzed and discussed in terms of the relation to experimentally observable ion mobility mass spectrometry cross sections. They also are compared to the neutral ubiquitin's native structure and to the nearly linear structure of the ubiquitin 13+ ion. In general, different charge distributions lead to substantially different structures and ion mobility cross sections. In this study, however, it was found that this is not always the case. Our conclusion is that measurements of ion mobility cross sections cannot be used to help determine a unique charge distribution because different charge distributions lead to structures that approximately agree in terms of experimental cross sections.

Superconducting Correlations Out of Repulsive Interactions on a Fractional Quantum Hall Edge.

We consider a fractional quantum Hall bilayer system with an interface between quantum Hall states of filling fractions (ν_{top},ν_{bottom})=(1,1) and (1/3,2), motivated by a recent approach to engineering artificial edges [Y. Ronen et al., Nat. Phys. 14, 411 (2018)NPAHAX1745-247310.1038/s41567-017-0035-2]. We show that random tunneling and strong repulsive interactions within one of the layers will drive the system to a stable fixed point with two counterpropagating charge modes which have attractive interactions. As a result, slowly decaying correlations on the edge become predominantly superconducting. We discuss the resulting observable effects and derive general requirements for electron attraction in Abelian quantum Hall states. The broader interest in fractional quantum Hall edge with quasi-long-range superconducting order lies in the prospects of hosting exotic anyonic boundary excitations, which may serve as a platform for topological quantum computation.

Management of the extraction socket and timing of implant placement: Consensus report and clinical recommendations of group 3 of the XV European Workshop in Periodontology.

BACKGROUND: The transition from a tooth requiring extraction to its replacement (with a dental implant) requires a series of clinical decisions related to timing, approach, materials, cost-effectiveness and the assessment of potential harm and patient preference. This workshop focused on the formulation of evidence-based consensus statements and clinical recommendations. METHODS: Four systematic reviews covering the areas of alveolar ridge preservation/bone grafting, immediate early and delayed implant placement and alveolar bone augmentation at the time of implant placement in a healed ridge formed the basis of the deliberations. The level of evidence supporting each consensus statement and its strength was described using a modification of the GRADE tool. RESULTS: The evidence base for each of the relevant topics was assessed and summarized in 23 consensus statements and 12 specific clinical recommendations. The group emphasized that the evidence base mostly relates to single tooth extraction/replacement; hence, external validity/applicability to multiple extractions requires careful consideration. The group identified six considerations that should assist clinicians in clinical decision-making: presence of infection, inability to achieve primary stability in the restoratively driven position, presence of a damaged alveolus, periodontal phenotype, aesthetic demands and systemic conditions. CONCLUSIONS: A substantial and expanding evidence base is available to assist clinicians with clinical decision-making related to the transition from a tooth requiring extraction to its replacement with a dental implant. More high-quality research is needed for the development of evidence-based clinical guidelines.

Knowledge and Opinion of Internists and Gynecologists Physicians on Periodontal Medicine.

PURPOSE: To evaluate the knowledge, opinions, and behaviours of physicians in the field of internal medicine and gynecology regarding periodontal disease and its systemic implications. METHODS: A questionnaire was distributed by hand and via e-mail to internists and gynecologists working in hospitals and community clinics. The questionnaires included items regarding personal and professional status, subject-related characteristics, dental history and knowledge in periodontal medicine. All completed questionnaires were reviewed and analysed according to discipline and personal experience. Statistical differences were tested using the chi-squared analysis. RESULTS: A total of 97 questionnaires were reviewed and included 56 internists and 41 gynecologists. The mean age was 39.7 years (range 29-82) and the percentage of females was 54%. Overall, general knowledge regarding periodontitis differed significantly between internists and gynecologists (80% vs 32% correct answers per group, respectively). Nearly 60% of responders (both internists and gynecologists) knew the correct cause of periodontal disease. Although half of the responders had personal experience in the field of periodontology, this experience was not noticeable regarding their knowledge in periodontal medicine. The majority of responders (58%) agreed that there is a need for more periodontal education in general medicine. CONCLUSIONS: The present study indicates a clear lack of knowledge of both internists and gynecologists regarding periodontitis and its systemic complications. Personal periodontal experience did not change the degree of familiarity with periodontal medicine.

CDB-a database for protein heterodimeric complexes.

Crystallographic structures of protein complexes are essential to develop proteomic and structural biology methods, as prediction of protein-protein interaction (PPI) sites and protein-protein docking. Such structures can aid the development of protein complexation inhibitors. Complex DataBase (CDB), accessible at www.jct-bioinfo.com/cdb/search, is a database web application for heterodimeric protein crystallographic complexes along with the crystallographic structures of each individual unbound protein. Direct access to crystallographic structures of protein complexes, along with provided annotations, can serve as starting point for constructing new experimental protein complexes sets of any type, for protein binding studies, and the development and evaluation of PPIs prediction methods.

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable. Clinical gingival health can be restored following treatment of gingivitis and periodontitis. However, the treated and stable periodontitis patient with current gingival health remains at increased risk of recurrent periodontitis, and accordingly, must be closely monitored. Two broad categories of gingival diseases include non-dental plaque biofilm-induced gingival diseases and dental plaque-induced gingivitis. Non-dental plaque biofilm-induced gingival diseases include a variety of conditions that are not caused by plaque and usually do not resolve following plaque removal. Such lesions may be manifestations of a systemic condition or may be localized to the oral cavity. Dental plaque-induced gingivitis has a variety of clinical signs and symptoms, and both local predisposing factors and systemic modifying factors can affect its extent, severity, and progression. Dental plaque-induced gingivitis may arise on an intact periodontium or on a reduced periodontium in either a non-periodontitis patient or in a currently stable "periodontitis patient" i.e. successfully treated, in whom clinical inflammation has been eliminated (or substantially reduced). A periodontitis patient with gingival inflammation remains a periodontitis patient (Figure 1), and comprehensive risk assessment and management are imperative to ensure early prevention and/or treatment of recurrent/progressive periodontitis. Precision dental medicine defines a patient-centered approach to care, and therefore, creates differences in the way in which a "case" of gingival health or gingivitis is defined for clinical practice as opposed to epidemiologically in population prevalence surveys. Thus, case definitions of gingival health and gingivitis are presented for both purposes. While gingival health and gingivitis have many clinical features, case definitions are primarily predicated on presence or absence of bleeding on probing. Here we classify gingival health and gingival diseases/conditions, along with a summary table of diagnostic features for defining health and gingivitis in various clinical situations.

Periodontal health and gingival diseases and conditions on an intact and a reduced periodontium: Consensus report of workgroup 1 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions.

Periodontal health is defined by absence of clinically detectable inflammation. There is a biological level of immune surveillance that is consistent with clinical gingival health and homeostasis. Clinical gingival health may be found in a periodontium that is intact, i.e. without clinical attachment loss or bone loss, and on a reduced periodontium in either a non-periodontitis patient (e.g. in patients with some form of gingival recession or following crown lengthening surgery) or in a patient with a history of periodontitis who is currently periodontally stable. Clinical gingival health can be restored following treatment of gingivitis and periodontitis. However, the treated and stable periodontitis patient with current gingival health remains at increased risk of recurrent periodontitis, and accordingly, must be closely monitored. Two broad categories of gingival diseases include non-dental plaque biofilm-induced gingival diseases and dental plaque-induced gingivitis. Non-dental plaque biofilm-induced gingival diseases include a variety of conditions that are not caused by plaque and usually do not resolve following plaque removal. Such lesions may be manifestations of a systemic condition or may be localized to the oral cavity. Dental plaque-induced gingivitis has a variety of clinical signs and symptoms, and both local predisposing factors and systemic modifying factors can affect its extent, severity, and progression. Dental plaque-induced gingivitis may arise on an intact periodontium or on a reduced periodontium in either a non-periodontitis patient or in a currently stable "periodontitis patient" i.e. successfully treated, in whom clinical inflammation has been eliminated (or substantially reduced). A periodontitis patient with gingival inflammation remains a periodontitis patient (Figure 1), and comprehensive risk assessment and management are imperative to ensure early prevention and/or treatment of recurrent/progressive periodontitis. Precision dental medicine defines a patient-centered approach to care, and therefore, creates differences in the way in which a "case" of gingival health or gingivitis is defined for clinical practice as opposed to epidemiologically in population prevalence surveys. Thus, case definitions of gingival health and gingivitis are presented for both purposes. While gingival health and gingivitis have many clinical features, case definitions are primarily predicated on presence or absence of bleeding on probing. Here we classify gingival health and gingival diseases/conditions, along with a summary table of diagnostic features for defining health and gingivitis in various clinical situations.

Symmetry-Resolved Entanglement in Many-Body Systems.

Similarly to the system Hamiltonian, a subsystem's reduced density matrix is composed of blocks characterized by symmetry quantum numbers (charge sectors). We present a geometric approach for extracting the contribution of individual charge sectors to the subsystem's entanglement measures within the replica trick method, via threading appropriate conjugate Aharonov-Bohm fluxes through a multisheet Riemann surface. Specializing to the case of 1+1D conformal field theory, we obtain general exact results for the entanglement entropies and spectrum, and apply them to a variety of systems, ranging from free and interacting fermions to spin and parafermion chains, and verify them numerically. We find that the total entanglement entropy, which scales as lnL, is composed of sqrt[lnL] contributions of individual subsystem charge sectors for interacting fermion chains, or even O(L^{0}) contributions when total spin conservation is also accounted for. We also explain how measurements of the contribution to the entanglement from separate charge sectors can be performed experimentally with existing techniques.

Suppression of Interference in Quantum Hall Mach-Zehnder Geometry by Upstream Neutral Modes.

Mach-Zehnder interferometry has been proposed as a probe for detecting the statistics of anyonic quasiparticles in fractional quantum Hall (FQH) states. Here, we focus on interferometers made of multimode edge states with upstream modes. We find that the interference visibility is suppressed due to downstream-upstream mode entanglement; the latter serves as a "which path" detector to the downstream interfering trajectories. Our analysis tackles a concrete realization of a filling factor of ν=2/3, but its applicability goes beyond that specific case, and encompasses the recent observation of the ubiquitous emergence of upstream neutral modes in FQH states. The latter, according to our analysis, goes hand in hand with the failure to observe Mach-Zehnder anyonic interference in fractional states. We point out how charge-neutral mode disentanglement will resuscitate the interference signal.

Radiographic outcomes following treatment of intrabony defects by freeze-dried bone allograft combined with enamel matrix derivative: A retrospective study.

OBJECTIVE: The aim of this study was to evaluate the radiographic outcomes following regenerative surgery using enamel matrix derivative (EMD) + freeze-dried bone allograft (FDBA). METHOD AND MATERIALS: In total, 74 two- or three-wall intrabony defects were treated by a combination of EMD+FDBA followed by supportive periodontal therapy (SPT) for a minimum of 2 years. Radiographs were taken at baseline and after the follow-up period. The measurements taken were: baseline defect angle, CEJ to the coronal part of the alveolar bone crest (CEJ-BC), CEJ to the apical part of the intrabony defect (CEJ- BD), the intrabony component of the defect (DL), and the defect angle between the lines CEJ-BC and CEJ-BD. RESULTS: Baseline defect angles were divided into three groups: first group defect angle ≤ 22 degrees; second group 22 degrees to 36 degrees; and third group ≥ 36 degrees. A significant difference in DL following treatment was found in all groups (6.930 mm, 4.202 mm, and 2.073 mm respectively; P < .01). The largest difference in DL was measured for the first group. A positive linear correlation was found between baseline values of the defect angle, CEJ-BD, CEJ-BC, and the later change in DL (P < .01). CONCLUSION: The use of EMD+FDBA results in radiographic bone gain. Narrow defect angle and the depth of the intrabony component have significant positive correlation to radiographic bone gain.

Primary prevention of peri-implantitis: managing peri-implant mucositis.

AIMS: Over the past decades, the placement of dental implants has become a routine procedure in the oral rehabilitation of fully and partially edentulous patients. However, the number of patients/implants affected by peri-implant diseases is increasing. As there are--in contrast to periodontitis--at present no established and predictable concepts for the treatment of peri-implantitis, primary prevention is of key importance. The management of peri-implant mucositis is considered as a preventive measure for the onset of peri-implantitis. Therefore, the remit of this working group was to assess the prevalence of peri-implant diseases, as well as risks for peri-implant mucositis and to evaluate measures for the management of peri-implant mucositis. METHODS: Discussions were informed by four systematic reviews on the current epidemiology of peri-implant diseases, on potential risks contributing to the development of peri-implant mucositis, and on the effect of patient and of professionally administered measures to manage peri-implant mucositis. This consensus report is based on the outcomes of these systematic reviews and on the expert opinion of the participants. RESULTS: Key findings included: (i) meta-analysis estimated a weighted mean prevalence for peri-implant mucositis of 43% (CI: 32-54%) and for peri-implantitis of 22% (CI: 14-30%); (ii) bleeding on probing is considered as key clinical measure to distinguish between peri-implant health and disease; (iii) lack of regular supportive therapy in patients with peri-implant mucositis was associated with increased risk for onset of peri-implantitis; (iv) whereas plaque accumulation has been established as aetiological factor, smoking was identified as modifiable patient-related and excess cement as local risk indicator for the development of peri-implant mucositis; (v) patient-administered mechanical plaque control (with manual or powered toothbrushes) has been shown to be an effective preventive measure; (vi) professional intervention comprising oral hygiene instructions and mechanical debridement revealed a reduction in clinical signs of inflammation; (vii) adjunctive measures (antiseptics, local and systemic antibiotics, air-abrasive devices) were not found to improve the efficacy of professionally administered plaque removal in reducing clinical signs of inflammation. CONCLUSIONS: Consensus was reached on recommendations for patients with dental implants and oral health care professionals with regard to the efficacy of measures to manage peri-implant mucositis. It was particularly emphasized that implant placement and prosthetic reconstructions need to allow proper personal cleaning, diagnosis by probing and professional plaque removal.