1.
Thromb Res
; 69(3): 307-13, 1993 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7682732
RESUMO
The comparative study of intratracheal and intravenous administration of heparin on blood coagulation and mast cell population was carried out in experiments in rats. Unlike the intravenous injection of heparin which induces fast short-time inactivation of all clotting factors, single intratracheal injection of heparin inactivated the intrinsic pathway of thrombin generation. Long-term hypocoagulability after intratracheal administration of heparin was related to the accumulation of heparin in mast cell.