[Pyogenic liver abscesses of cryptogenic origin]. / Abscesos hepáticos piógenos de origen criptogenético.

OBJECTIVE: To analyze and clarify the clinical behaviour and outcome of patients with pyogenic liver abscess of cryptogenic origin and, moreover, to observe if there are any differential characteristics in relation to those found in patients with a known pathogenesis. MATERIAL AND METHODS: Multicenter and retrospective study of two groups of patients diagnosed of pyogenic liver abscess, during a period of 13 years. Group 1: 34 cases with abscess of cryptogenic origin and Group 2: 99 patients with a known pathogenesis. Clinical, laboratory, and microbiologic data, morphology and topography of the lesions, treatment and outcome were assessed and compared in both groups. RESULTS: The duration of symptomatology was higher in Group 1 (9.4 +/- 6.5 vs 8.1 +/- 4.4 days; p = 0.05). Although, in this category of patients, it was also observed a lower frequency of jaundice (6 vs 26%; p = 0.02) and lower level of bilirubinemia (0.9 +/- 0.9 vs 2.6 +/- 4.4 mg/dl; p = 0.05), the majority of clinical and laboratory data were similar in both groups. The rate of patients with abscesses on the left lobe (26% vs 12%; p = 0.04) was higher in Group 1. The therapeutic modality carried out in the two groups was not significantly different, neither were hospital stay, and morbidity and mortality rates. CONCLUSIONS: The patients with pyogenic liver abscesses of cryptogenic origin present few specific clinical characteristics which facilitate the diagnosis. Besides, their outcome was no significantly different from that found in patients with abscesses of known pathogenesis.

[Pyogenic liver abscesses in cancer patients]. / Abscesos hepáticos piógenos en pacientes con cáncer.

OBJECTIVE: To analyse the clinical behaviour of pyogenic liver abscesses among cancer patients, and to determine whether there is any difference between clinical behaviour among patients without malignancies. PATIENTS AND METHODS: Retrospective, multicentric study with 133 patients with pyogenic liver abscesses diagnosed during 13 years. Patients were divided into two groups: 29 patients with malignant tumors identified during the five years prior to abscess development (group 1) and 104 patients without malignant tumors (group 2). Clinical, biological and bacteriological findings, morphology and lesional topography, treatment and particularly, clinical course were analysed. RESULTS: Abscesses with portal pathogenesis were more common in group 1 (24% versus 10%; p = 0.03). Clinical and biological data were similar in both group but jaundice (31% versus 18%; p = 0.09), liver enlargement (38% versus 21%; p = 0.06) and pleural effusion (48% versus 28%; p = 0.03), which were more common in group 1. In the same group, the mean AST level was also higher (112 149 versus 60 88; p = 0.07 ). Morphology and lesional topography, as well as bacteriology in both groups did not differ significantly. In group 1, surgical drainage was performed less frequently (21% versus 38%; p = 0.09) and mortality rate was higher (24% versus 11%; p = 0.08). Nevertheless, no significant differences were observed between hospital stay and morbidity. Among patients treated with antibiotics only, the mortality rate was higher in group 1 (50% versus 10%; p = 0.06). CONCLUSIONS: In pyogenic liver abscess in patients with malignant tumor disease a predominance of portal pathogenesis was observed. The presence of cancer among patients with pyogenic liver abscesses did not imply a significantly different clinical presentation; however, the clinical course was worse than that observed in cases without cancer.

Gallstone disease in patients over the age of 80. Surgery or long-term medical treatment?

OBJECTIVE: Growth in the geriatric population is increasing the biliary pathology of the elderly, thus becoming more frequent in the medical environment. The different therapeutic methods that are at present in use, should be applied to this group, employing open cholecystectomy as a reference. MATERIAL AND METHODS: During a period of 5 years we have attended 209 patients over the age of 80 (13.8 of the total of gallstones), 76 patients (36.4%) underwent surgery and in 133 cases (63.6%) another therapeutic method was decided upon. The progression, complications and mortality rate are studied closely herein. RESULTS: The majority, 156 (74.6%) were not previous admissions and in 108 (51.7%) the symptoms had been present for less than one month. Eighty four (40.2%) were suffering from jaundice on admission (on average 4 days) and 89 (42.6%) showed signs of inflammation. 23 patients (11%) were submitted only to an endoscopic sphincterotomy. Of those patients who underwent surgery, 52 (67.5%) had a range of inflammatory phenomena. Open cholecystectomy was carried out on 65 patients (85.5%). Sixty one patients (29.2%) presented complications, 38 (50%) in the group underwent surgery. Twenty eight patients (13.4%) died-9 (11.8%) of the 76 patients were operated upon. CONCLUSIONS: Elderly patients can undergo surgery in selected cases with an acceptable mortality rate and high morbidity. Surgery is recommended in those of a lesser age, not always possible as many of them lacked prior symptoms.

Hepatic metastases of granulosa cells tumour of the ovary.

A case of metastatic granulosa cell tumour of the ovary is reported. Investigations revealed a secondary tumour in segment VI and VII of the liver. Right hepatic resection was performed. Microscopic findings revealed a tumour with histological features identical to that removed eleven years before.

[Postoperative digestive upper fistula. Study of 37 cases]. / Fístulas digestivas altas posquirúrgicas. Estudio de 37 casos.

We report a series of 37 patients with upper gastrointestinal fistulas, from a total of 90 postoperative fistulas, treated in our Department over a period of five years (1987-1991). 46% of these originated after peptic ulcer surgery. Most patients (54%) required surgical intervention mainly due to the presence of major intraabdominal sepsis, and only 12 (32.4%) had spontaneous fistula closure. Morbidity (59.4%) and mortality rates (32.4%) were high.

[The prognosis of colorectal cancer with synchronous liver metastases]. / Pronóstico del cáncer colorrectal con metástasis hepáticas sincrónicas.

Between January 1985 and December 1989, 583 patients with carcinoma of the colon and rectum have been studied. In 85 with synchronous liver metastases discovered at laparotomy and followed-up, median survival time has been 5.8 months and 1 and 3 year survival 23 and 6 percent respectively. Favorable factors for survival were rectosigmoid location, single metastasis in the right hepatic lobe, normal values of alkaline phosphatase, resection of the tumor as well as stage II of Duke's classification.

[Septic complications following splenectomy after abdominal trauma]. / Complicaciones sépticas postesplenectomía tras traumatismo abdominal.

We reviewed retrospectively the septic postsplenectomy complications after splenic rupture from abdominal trauma in 53 patients treated in the last five years (1984-1988). We recorded a higher incidence of complications (pneumonia, subphrenic abscess) in these patients than in those who underwent clean surgery during the same period, but we did not demonstrate the same difference in other infectious processes (infection of the surgical wound). Infections had a higher incidence in patients with splenic rupture with associated lesions (54.10%) than in those with only a splenic lesion (37.50%) (SD p less than 0.05). The predominant agents usually isolated were aerobic Gram-positive. We remark the importance of open drainage systems (Penrose type) in the genesis of subphrenic abscesses.

[Gastric volvulus. Presentation of a new case and review of the literature]. / Vólvulo gástrico. Aportación de un nuevo caso y revisión de la literatura.

A case is presented of acute gastric volvulus associated with paraesophageal hernia. Gastric volvulus is an infrequent clinical entity that generally appears in chronic form secondary to diaphragmatic pathology. Pathogenesis rests on two factors, relaxation of the supporting ligaments and neighboring associated pathology that acts to trigger gastric distension. Early diagnosis and treatment of acute forms and prophylactic surgery of chronic forms would lead to practically null mortality figures. The surgical technique, aside from devolvulation, includes hiatal repair in cases associated with paraesophageal hernia, gastropexy being sufficient for other forms.