RESUMO
The progression of coccidiosis provoked by Eimeria acervulina was followed in chicks fed on OTA-contaminated as well as on OTA-free diets. More heavy progress of duodenal coccidiosis, including mortality, occurred in OTA-treated chicks as can be seen from the higher value of lesion (3.50) and oocyst (31.65) indices. A stronger decrease of serum total protein was found in OTA-treated chicks (22.80 g/l) than in chicks infected with E. acervulina(24.20 g/l), but that decrease was strongest in chicks treated with OTA and simultaneously infected with E. acervulina (19.71 g/l). The serum concentration of uric acid was significantly increased in all chicks exposed to OTA, most notably in those additionally infected with E. acervulina (1020.6 (micro mol/L), whereas the serum enzyme activity of AST was increased only in chicks infected with E. acervulina and highest in those fed OTA contaminated diet (122.2 U/L). OTA induced degenerative changes in kidneys, liver and heart as well as a depletion of lymphoid tissue in the lymphoid organs and a decrease of body weight. Coccidiosis induced only a slight growth depression and duodenal hemorrhages in addition to characteristic duodenal damages. The impairment of kidney function, histopathological changes and general growth depression were stronger when chicks infected with E. acervulina were also given OTA.
Assuntos
Galinhas , Coccidiose/veterinária , Eimeria/crescimento & desenvolvimento , Ocratoxinas/administração & dosagem , Doenças das Aves Domésticas/parasitologia , Animais , Aspartato Aminotransferases/sangue , Peso Corporal , Bolsa de Fabricius/parasitologia , Bolsa de Fabricius/patologia , Cerebelo/parasitologia , Cerebelo/patologia , Coccidiose/metabolismo , Coccidiose/parasitologia , Coccidiose/patologia , Contaminação de Alimentos , Histocitoquímica , Mucosa Intestinal/parasitologia , Mucosa Intestinal/patologia , Rim/parasitologia , Rim/patologia , Fígado/parasitologia , Fígado/patologia , Ocratoxinas/metabolismo , Doenças das Aves Domésticas/metabolismo , Doenças das Aves Domésticas/patologia , Organismos Livres de Patógenos Específicos , Estatísticas não Paramétricas , Ácido Úrico/sangueRESUMO
Pathomorphological investigations of internal organs were made in sheep given sublethal doses of cadmium. Early histological damages in kidneys were established by renal biopsy in some experimental animals. The main histological changes were characterized by granular degeneration in proximal tubules and glomerular endothelial proliferation in kidneys, granular degeneration in hepatocytes, pericapillary oedema and activation of capillary endothelium and Kupffer cells in liver, oedematous and degenerative changes in cerebrum and in the region of Purkinje cells of cerebellum, hyperplasia and proliferation of alveolar epithelium and perivascular or peribronchial mononuclear cell infiltration in lung, and degenerative changes in the medulla and zona glomerulosa of adrenal glands.