Research on the Application of New Building Recycled Insulation Materials for Walls.

In this paper, a new type of recycled polyurethane material is used as a new type of wall insulation material, and the new building insulation wall made of this paper has high efficiency thermal insulation and energy-saving characteristics and also has certain environmental significance. The thermal conductivity of the new building cold insulation recycled polyurethane material is 0.023 W/(m·K), and the thermal conductivity of the new building insulation wall prepared is 0.297 W/(m·K). Compared with traditional double-sided plastered porous wall tiles, it can save 85.4% of energy consumption per square meter, with higher thermal insulation characteristics and economic benefits. The preparation of a new type of building insulation wall proposed in this paper provides a new and green way for wall insulation.

Airway basal cell­derived exosomes suppress epithelial­mesenchymal transition of lung cells by inhibiting the expression of ANO1.

Disruption of the epithelial-mesenchymal transition (EMT) of activated lung cells is an important strategy to inhibit the progression of idiopathic pulmonary fibrosis (IPF). The present study investigated the role of exosomes derived from airway basal cells on EMT of lung cells and elucidate the underlying mechanism. Exosomes were characterized by nanoparticle tracking analysis, transmission electron microscopy imaging and markers detection. The role of exosome on the EMT of lung epithelial cells and lung fibroblasts induced by TGF-ß1 was detected. RNA sequencing screened dysregulated genes in exosome-treated group, followed by the bioinformatical analysis. One of the candidates, anoctamin-1 (ANO1), was selected for further gain-and-loss phenotype assays. A bleomycin-induced pulmonary fibrosis model was used to evaluate the treatment effect of exosomes. Exosomes were round-like and positively expressed CD63 and tumor susceptibility gene 101 protein. Treatment with exosomes inhibited the EMT of lung cells activated by TGF-ß1. 4158 dysregulated genes were identified in exosome-treated group under the threshold of |log2 fold-change| value >1 and they were involved in the metabolism of various molecules, as well as motility-related biological processes. A key gene, ANO1, was verified by reverse transcription-quantitative PCR, whose overexpression induced the EMT of lung cells. By contrast, ANO1 knockdown reversed the EMT induced by TGF-ß1. In vivo assay indicated that exosome treatment ameliorated pulmonary fibrosis and inhibited the upregulation of ANO1 induced by bleomycin. In conclusion, airway basal cell-derived exosomes suppressed the EMT of lung cells via the downregulation of ANO1. These exosomes represent a potential therapeutic option for patients with IPF.

Analysis of Factors Affecting the Preparation of Mullite Whiskers from Silica-Rich Slag and Application Studies.

This paper presents an in-depth comparative study of the effects of different molten salt systems, catalyst additions, preparation temperatures, temperature rise rates, and holding times on the properties of mullite whiskers during their preparation process, as well as exploring the enhancement of the toughening effect of mullite whiskers on ceramics. The morphology, crystal structure, and composition of the whiskers were analyzed via SEM, XRD, TG, strength tests, etc. The results show that the best-performing mullite whisker was prepared with an aluminum sulfate molten salt system, with the addition of aluminum fluoride catalyst at 4%, a temperature increase rate of 5 °C, a temperature increase up to 850 °C, and a holding time of 5 h, and its aspect ratio reached 20.64. By adding different contents of mullite whiskers and comparing the toughness strengths and wear rates of the silicon carbide ceramics, it was found that the toughness strength of the ceramics was improved by more than 16.5% and the wear rate was lower than 0.4% when the addition of mullite whisker was more than 3%.

Chinese experts' consensus on the application of intensive care big data.

The development of intensive care medicine is inseparable from the diversified monitoring data. Intensive care medicine has been closely integrated with data since its birth. Critical care research requires an integrative approach that embraces the complexity of critical illness and the computational technology and algorithms that can make it possible. Considering the need of standardization of application of big data in intensive care, Intensive Care Medicine Branch of China Health Information and Health Care Big Data Society, Standard Committee has convened expert group, secretary group and the external audit expert group to formulate Chinese Experts' Consensus on the Application of Intensive Care Big Data (2022). This consensus makes 29 recommendations on the following five parts: Concept of intensive care big data, Important scientific issues, Standards and principles of database, Methodology in solving big data problems, Clinical application and safety consideration of intensive care big data. The consensus group believes this consensus is the starting step of application big data in the field of intensive care. More explorations and big data based retrospective research should be carried out in order to enhance safety and reliability of big data based models of critical care field.