Potential assessment of CO2 source/sink and its matching research during CCS process of deep unworkable seam.

It is of great significance for the engineering popularization of CO2-ECBM technology to evaluate the potential of CCUS source and sink and study the matching of pipeline network of deep unworkable seam. In this study, the deep unworkable seam was taken as the research object. Firstly, the evaluation method of CO2 storage potential in deep unworkable seam was discussed. Secondly, the CO2 storage potential was analyzed. Then, the matching research of CO2 source and sink was carried out, and the pipe network design was optimized. Finally, suggestions for the design of pipe network are put forward from the perspective of time and space scale. The results show that the average annual CO2 emissions of coal-fired power plants vary greatly, and the total emissions are 58.76 million tons. The CO2 storage potential in deep unworkable seam is huge with a total amount of 762 million tons, which can store CO2 for 12.97 years. During the 10-year period, the deep unworkable seam can store 587.6 million tons of CO2, and the cumulative length of pipeline is 251.61 km with requiring a cumulative capital of $ 4.26 × 1010. In the process of CO2 source-sink matching, the cumulative saving mileage of carbon sink is 98.75 km, and the cumulative saving cost is $ 25.669 billion with accounting for 39.25% and 60.26% of the total mileage and cost, respectively. Based on the three-step approach, the whole line of CO2 source and sink in Huainan coalfield can be completed by stages and regions, and all CO2 transportation and storage can be realized. CO2 pipelines include gas collection and distribution branch lines, intra-regional trunk lines, and interregional trunk lines. Based on the reasonable layout of CO2 pipelines, a variety of CCS applications can be simultaneously carried out, intra-regional and inter-regional CO2 transport network demonstrations can be built, and integrated business models of CO2 transport and storage can be simultaneously built on land and sea. The research results can provide reference for the evaluation of CO2 sequestration potential of China's coal bases, and lay a foundation for the deployment of CCUS clusters.

Comprehensive Analysis of Connectivity and Permeability of a Pore-Fracture Structure in Low Permeability Seam of Huainan-Huaibei Coalfield.

The connectivity and permeability of the coal seam pore structures control the occurrence and migration of coalbed methane. Coal samples were used from Huainan-Huaibei to reconstruct three-dimensional models of the pores and an equivalent pore network model, Statistical pore structure characteristic parameters. The pore structure of the coal reservoir was analyzed from the direction of multidimensional and multiangle. It shows that based on quantitative analysis, the representative Elementary volume of 500 × 500 × 500 was the most suitable experimental volume. The Y-axis direction of the Renlou sample had poor pore connectivity compared to that of other samples. Large volume connected pores dominated their pore systems. In terms of coal sample pore connectivity, the coal samples from the Liuzhuang and Qidong regions had pore connectivity better than those from the other regions. The pore connectivity of the Liuzhuang coal samples was the best. In terms of coal permeability, the Liuzhuang sample had better permeability than the other three samples, and the permeability was the best in the Y-axis direction. For all the combinations of the different types of throats, the shorter the throat, the greater the equivalent radius and the better the permeability. Conversely, the worse the permeability. During gas injection production, the closer the gas injection area was to the gas injection well, the poorer the connectivity and the lower the permeability over time. Near the production area, where the CO2 did not reach the production area, the fracture porosity and effective connected porosity of the coal reservoir increased over time. When CO2 reached the production area, the change in its connected pore structure was consistent with the change in the connected pores in the gas injection area. With this study, the coal seam pore structure on a microscale was characterized. A comprehensive analysis of the coal reservoir pore connectivity and permeability was completed. The study results are significant for the exploration and development of coalbed methane in the Huainan-Huaibei coalfield.

PRMT5 activates lipid metabolic reprogramming via MYC contributing to the growth and survival of mantle cell lymphoma.

Mantle cell lymphoma (MCL) is an incurable and aggressive subtype of non-Hodgkin B-cell lymphoma. Increased lipid uptake, storage, and lipogenesis occur in a variety of cancers and contribute to rapid tumor growth. However, no data has been explored for the roles of lipid metabolism reprogramming in MCL. Here, we identified aberrant lipid metabolism reprogramming and PRMT5 as a key regulator of cholesterol and fatty acid metabolism reprogramming in MCL patients. High PRMT5 expression predicts adverse outcome prognosis in 105 patients with MCL and GEO database (GSE93291). PRMT5 deficiency resulted in proliferation defects and cell death by CRISPR/Cas9 editing. Moreover, PRMT5 inhibitors including SH3765 and EPZ015666 worked through blocking SREBP1/2 and FASN expression in MCL. Furthermore, PRMT5 was significantly associated with MYC expression in 105 MCL samples and the GEO database (GSE93291). CRISPR MYC knockout indicated PRMT5 can promote MCL outgrowth by inducing SREBP1/2 and FASN expression through the MYC pathway.