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1.
bioRxiv ; 2024 Aug 30.
Artigo em Inglês | MEDLINE | ID: mdl-39253477

RESUMO

Speech perception declines independent of hearing thresholds in middle-age, and the neurobiological reasons are unclear. In line with the age-related neural dedifferentiation hypothesis, we predicted that middle-aged adults show less distinct cortical representations of phonemes and acoustic-phonetic features relative to younger adults. In addition to an extensive audiological, auditory electrophysiological, and speech perceptual test battery, we measured electroencephalographic responses time-locked to phoneme instances (phoneme-related potential; PRP) in naturalistic, continuous speech and trained neural network classifiers to predict phonemes from these responses. Consistent with age-related neural dedifferentiation, phoneme predictions were less accurate, more uncertain, and involved a broader network for middle-aged adults compared with younger adults. Representational similarity analysis revealed that the featural relationship between phonemes was less robust in middle-age. Electrophysiological and behavioral measures revealed signatures of cochlear neural degeneration (CND) and speech perceptual deficits in middle-aged adults relative to younger adults. Consistent with prior work in animal models, signatures of CND were associated with greater cortical dedifferentiation, explaining nearly a third of the variance in PRP prediction accuracy together with measures of acoustic neural processing. Notably, even after controlling for CND signatures and acoustic processing abilities, age-group differences in PRP prediction accuracy remained. Overall, our results reveal "fuzzier" phonemic representations, suggesting that age-related cortical neural dedifferentiation can occur even in middle-age and may underlie speech perceptual challenges, despite a normal audiogram.

2.
Artigo em Inglês | MEDLINE | ID: mdl-38959144

RESUMO

Pathological examination of nasopharyngeal carcinoma (NPC) is an indispensable factor for diagnosis, guiding clinical treatment and judging prognosis. Traditional and fully supervised NPC diagnosis algorithms require manual delineation of regions of interest on the gigapixel of whole slide images (WSIs), which however is laborious and often biased. In this paper, we propose a weakly supervised framework based on Tokens-to-Token Vision Transformer (WS-T2T-ViT) for accurate NPC classification with only a slide-level label. The label of tile images is inherited from their slide-level label. Specifically, WS-T2T-ViT is composed of the multi-resolution pyramid, T2T-ViT and multi-scale attention module. The multi-resolution pyramid is designed for imitating the coarse-to-fine process of manual pathological analysis to learn features from different magnification levels. The T2T module captures the local and global features to overcome the lack of global information. The multi-scale attention module improves classification performance by weighting the contributions of different granularity levels. Extensive experiments are performed on the 802-patient NPC and CAMELYON16 dataset. WS-T2T-ViT achieves an area under the receiver operating characteristic curve (AUC) of 0.989 for NPC classification on the NPC dataset. The experiment results of CAMELYON16 dataset demonstrate the robustness and generalizability of WS-T2T-ViT in WSI-level classification.

3.
iScience ; 26(12): 108419, 2023 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-38053638

RESUMO

Batteries may degrade fast at extreme temperatures, posing a challenge in meeting the dual requirements of heat preservation at low temperatures and efficient cooling at high temperatures. To address this issue, we propose a cavity structure-based active controllable thermal switch. It has a potential switch ratio (SR) of approximately 300, with an experimental SR of 15.4. Furthermore, the thermal resistance can be actively controlled. The "OFF State" of the thermal switch increases energy discharge at low temperatures. Pre-heating with the "OFF State" consumes only 60% of the energy required in the "ON State". By employing the "ON State" at an ambient temperature of 20°C, the battery temperature can be maintained below 35°C. And the "ON + State" keeps the maximum battery temperature remaining below 42°C under extreme conditions. These findings demonstrate that the implementation of the proposed thermal switch enhances the usability of batteries in extreme environments.

4.
JASA Express Lett ; 2(4): 045202, 2022 04.
Artigo em Inglês | MEDLINE | ID: mdl-36154225

RESUMO

Listeners tend to perceive longer vowels as word-final and include the aspiration of a syllable-onset consonant in metalinguistically judging the duration of the following vowel. It may be hypothesized that longer aspiration is interpreted as extra vowel duration and hence, a word-finality cue. Alternatively, if aspiration is perceived as part of the onset, longer aspiration should be interpreted as word-initial, consistent with previous findings on consonant lengthening [White, Mattys, Stefansdottir, and Jones (2015). J. Acoust. Soc. Am. 138(2), 1214-1220]. An artificial language learning experiment with Taiwanese Southern Min listeners showed that lengthening aspiration in word-initial but not word-final syllables improved speech segmentation, supporting the second but not the first hypothesis.


Assuntos
Percepção da Fala , Fala , Humanos , Idioma , Aprendizagem , Fonética
5.
Lang Speech ; 64(2): 437-466, 2021 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-34110259

RESUMO

Experience with native-language prosody encourages language-specific strategies for speech segmentation. Conflicting findings from previous research suggest that these strategies may not be abstracted away from the acoustic manifestation of prosodic features in the native speech. Using the artificial language learning paradigm, the current study explores this possibility in connection with listeners of a lexical tone language called Taiwanese Southern Min (TSM). In TSM, the only rising lexical tone occurs almost only on the final syllable of the language's tone sandhi domain and is phonetically associated with final lengthening. Based on these observations, Experiment I examined what constituted a sufficient finality cue for use by TSM listeners to support segmentation: (a) final fundamental frequency (F0) rise only; or (b) final F0 rise conjoined with final lengthening. The results showed that segmentation was inhibited by the former cue but facilitated by the latter. Experiment II showed that the facilitation cannot be attributed entirely to final lengthening, as a null effect was found when final lengthening was the sole prosodic cue to segmentation. It is thus assumed that acoustic details as fine-grained as the lengthening of the rising tone are involved in the modulation of the segmentation strategy whereby TSM listeners perceive F0 rise as signaling finality. The inhibitory effect of final F0 rise alone found in Experiment I motivated Experiment III, which revealed that initial F0 rise in the absence of lengthening cues improved TSM listeners' segmentation. It is speculated that such use of initial F0 rise might reflect a cross-linguistic segmentation solution.


Assuntos
Idioma , Percepção da Fala , Sinais (Psicologia) , Humanos , Fonética , Fala
6.
J Acoust Soc Am ; 149(3): 1866, 2021 03.
Artigo em Inglês | MEDLINE | ID: mdl-33765826

RESUMO

A review of previous speech segmentation research suggests the prediction that listeners of Taiwanese Southern Min (TSM), a lexical tone language, would exploit vowel lengthening and syllable-onset consonant lengthening to locate word ends and beginnings, respectively. Yet, correlations between segment duration and tone identity in tone languages along with some TSM-specific phonological phenomena may work against such use. Two artificial language learning experiments examined TSM listeners' use of the lengthening cues. The listeners heard the words of an artificial language (e.g., /ba.nu.me/) repeated continuously and identified them in a subsequent two-alternative forced-choice test. Experiment I revealed that their segmentation benefits from and only from word-initial onset lengthening or word-final vowel lengthening, supporting the prediction. Experiment II further demonstrated that these two cues in combination synergistically support segmentation at least when compared to word-initial onset lengthening alone, consistent with previous findings regarding complementary cues. These results furnish additional evidence that vowel and onset consonant lengthening affect segmentation in different ways, possibly reflecting a functional division between vowels and consonants that is supported by some prosody-computing mechanism. Additionally, vowel lengthening seems to affect segmentation to a greater extent than onset consonant lengthening. Possible explanations for this and further issues are discussed.


Assuntos
Percepção da Fala , Fala , Humanos , Idioma , Desenvolvimento da Linguagem , Fonética
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