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1.
Clin Infect Dis ; 72(9): 1660-1666, 2021 05 04.
Artigo em Inglês | MEDLINE | ID: mdl-32766824

RESUMO

This review highlights the clinical and epidemiologic characteristics of coronavirus disease 2019 (COVID-19) in children and neonates and contrasts these features with other common respiratory viruses. Although the majority of infections in children are mild, there are many important, as yet, unanswered questions (specifically, the attack rate in children and the role of children as vectors of infection) that will have a major impact on disease in adults. There are no distinctive clinical characteristics that will allow the infectious disease consultant to make the diagnosis without laboratory testing. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) appears to be less common, with lower morbidity and mortality than respiratory syncytial virus or influenza, and causes less-severe disease in children with cancer than these more common viruses. The range of severity of infection during pregnancy is comparable to infection in nonpregnant cohorts. Intrauterine infection has been documented but is uncommon. A theme of less-severe disease in individuals with modulated immune systems is emerging.


Assuntos
COVID-19 , Doenças Transmissíveis , Vírus , Adulto , Criança , Doenças Transmissíveis/epidemiologia , Feminino , Humanos , Recém-Nascido , Gravidez , SARS-CoV-2
2.
Pediatr Emerg Care ; 36(10): e579-e581, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-32205801

RESUMO

Blastomyces dermatitidis is a dimorphic fungus endemic to the United States and Canada. Although both Histoplasma and Blastomyces are found in similar geographic regions, Blastomyces is many times more likely to cause dissemination in the immunocompetent host, frequently involving the bone. However, given the indolent nature of this fungal infection and more prevalent bacterial etiologies of osteomyelitis, diagnosis and treatment are often significantly delayed. We review 2 pediatric cases that initially presented with isolated orthopedic symptoms without documented fever or pulmonary complaints, although both had signs of pulmonary infection on imaging. These cases demonstrate the importance of a high level of suspicion as well as appropriate diagnostic workup, including surgical pathology with fungal stains, when evaluating osteomyelitis in patients exposed to a Blastomyces-endemic region.


Assuntos
Blastomicose/diagnóstico , Blastomicose/terapia , Osteomielite/microbiologia , Osteomielite/terapia , Criança , Diagnóstico Diferencial , Feminino , Humanos
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