RESUMO
In a group of 43 school-children living near a zinc plant, the test of granulocyte viability by the method of Cocchi et al, the lead level by flame atomic absorptiometry, and the level of erythrocyte zinc-protoporphyrin by the fluorimetric method were determined in peripheral blood. The mean result of the granulocyte viability test was 6.49%. In 18 children, the proportion of abnormal granulocytes was raised abnormally above 6.0%. The lead level was in the range from 14.1 to 53 micrograms/dl, and the level of erythrocyte ZPP was from 0.3 to 2.1 micrograms/g Hb. No correlation was found between the results of the granulocyte viability test and the blood lead level. The result of a comparison with the ZPP value was of borderline significance (p = 0.05).
Assuntos
Poluição Ambiental/efeitos adversos , Granulócitos/fisiologia , Sobrevivência Celular , Criança , Eritrócitos/análise , Humanos , Chumbo/sangue , Protoporfirinas/sangueAssuntos
Poluentes Atmosféricos/intoxicação , Intoxicação por Chumbo/diagnóstico , Ácido Aminolevulínico/urina , Criança , Coproporfirinas/urina , Exposição Ambiental , Seguimentos , Humanos , Chumbo/metabolismo , Intoxicação por Chumbo/tratamento farmacológico , Metalurgia , Polônia , Fatores de TempoRESUMO
In a boy aged 42 months, small stature, retarded psychomotor development, dry skin, excessive thirst, polyuria, cryptorchidism, and rickets were signs of multihormonal disturbances. Contrary to the clinical manifestations, laboratory investigations showed normal or raised levels of hormones (hGH, insulin, T3RU, T4, TSH, PTH). The cAMP level in the plasma was low and its urinary excretion was reduced. After administration of hGH, adrenaline, T3, T4, pitressin, vitamin D3 and aminophylline there was no rise in the cAMP concentration in plasma and urine. In the light of these results it may be assumed that deficient function of the adenyl cyclase system led to development of a clinical syndrome of tissue insensitivity to multiple hormonal factors in this case.