Correction to: Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy.

CORRECTION: Following publication of the original article [1], the authors reported that additional file 10 contained a typing error in the table "Percentage of responders (≥50% max TOTPAR) over two, four, six and eight hours (single-dose phase) (ITT Population)". The table is to be read as follows.

Dexketoprofen/tramadol 25 mg/75 mg: randomised double-blind trial in moderate-to-severe acute pain after abdominal hysterectomy.

BACKGROUND: Dexketoprofen trometamol plus tramadol hydrochloride is a new oral combination of two analgesics, which have different mechanisms of action for the treatment of moderate to severe acute pain. METHODS: Randomised, double-blind, parallel, placebo and active-controlled, single and multiple-dose study to evaluate the analgesic efficacy and safety of dexketoprofen/tramadol 25 mg/75 mg in comparison with the single agents (dexketoprofen 25 mg and tramadol 100 mg) in moderate to severe acute pain after abdominal hysterectomy. Patients received seven consecutive doses of study drug within a 3-day period, each dose separated by an 8-hour interval. A placebo arm was included during the single-dose phase to validate the pain model. Efficacy assessments included pain intensity, pain relief, patient global evaluation and use of rescue medication. The primary endpoint was the mean sum of pain intensity differences over the first 8 h (SPID8). RESULTS: The efficacy analysis included 606 patients, with a mean age of 48 years (range 25-73). The study results confirmed the superiority of the combination over the single agents in terms of the primary endpoint (p <0.001). Secondary endpoints were generally supportive of the superiority of the combination for both single and multiple doses. Most common adverse drug reactions (ADRs) were nausea (4.6%) and vomiting (2.3%). All other ADRs were experienced by less than 2% of patients. CONCLUSIONS: The study results provided robust evidence of the superiority of dexketoprofen/tramadol 25 mg/75 mg over the single components in the management of moderate to severe acute pain, as confirmed by the single-dose efficacy, repeated-dose sustained effect and good safety profile observed. TRIAL REGISTRATION: EU Clinical Trials Register (EudraCT number 2012-004545-32, registered 04 October 2012); Clinicaltrials.gov ( NCT01904149, registered 17 July 2013).

[Family-centered obstetrics in Hungary]. / A családközpontú szülészet helyzete Magyarországon.

The author has carried out a survey at hospitals in Hungary to examine how general family-centred obstetrics is, and to what extent obstetrics departments are able to meet the increasing demand for this exerted by society. In the course of the survey he focused on the characteristics of obstetrics departments, the preparation for delivery and maternity, open delivery-rooms, delivery with the partner, early mother-baby contact and rooming-in, and to what extent these operate. He describes the findings on the basis of data returned by 87 maternity departments, 81.3% of the total number of institutions in the country. The data reveals that 96.6% of wards have preparatory courses for delivery and maternity, 98.8% of open-delivery rooms welcome the partner at the delivery, early mother-baby contact is possible in 97.7% and 95.6% offer rooming-in. The study gives a comprehensive view of the present state of family-centred obstetrics offering an opportunity for everyone to re-evaluate their practices and to set up new objectives so that every mother and family can have easy access to family-centred obstetrics.

The present state of family-centered obstetrics in Hungary: preparation for the delivery, open delivery-room, rooming-in.

This paper gives details of a survey carried out at hospitals in Hungary to examine how widespread family-centred obstetrics is, and to what extent obstetrics departments are able to meet the increasing demands exerted by society. Several aspects were focused on, including the characteristics of obstetrics departments, the preparation for delivery and maternity, open delivery-rooms, delivery with the partner, early mother-baby contact, rooming-in and to what extent they operate. The study describes the findings on the basis of data sent back by 87 maternity departments, 81.3% of the institutions in the country. The data reveals that 96.6% of wards have preparatory courses for delivery and maternity, 98.8% of open delivery-rooms welcome the partner at the delivery, early mother-baby contact is possible in 97.7%, and 95.6% offer rooming-in. The study gives a comprehensive view of the present state of family-centred obstetrics, offering an opportunity for everyone to re-evaluate their practices and set up new objectives so that every mother and family can have easy access to family-centred obstetrics.

Neurofibromatosis type 1 with pregnancy-associated renovascular hypertension and the syndrome of hemolysis, elevated liver enzymes, and low platelets.

The authors detected a case of neurofibromatosis type 1 complicated with preeclampsia and the syndrome of hemolysis, elevated liver enzymes, and low platelets, which developed during pregnancy. When the cause of the patient's hypertension was investigated after birth, renal stenosis of the right artery was detected, which was then successfully treated with percutaneous transluminal angioplasty.

A comparative study of vertical and horizontal deliveries in the presence and with the assistance of the woman's partner.

The authors are the first in Hungary to have applied the method of vertical delivery with the husband's or partner's presence in the delivery room. This is part of the authors' family-centered delivery program at the Maternity Ward of Borsod-Abauj-Zemplén County Hospital, Miskolc. A comparison of 321 births was carried out, which included 158 vertical deliveries and 163 horizontal deliveries. During both vertical and horizontal deliveries, the husband or partner was present in the delivery room. The comparison included the mother's biometrics and social characteristics, as well as the circumstances of the delivery and the clinical parameters of the newborns. Certain stages of delivery in the vertical position took a shorter period of time compared to horizontal delivery, but the differences were not significant. Episiotomies were carried out in fewer cases of vertical deliveries, and significant injuries due to the lack of an episiotomy in the case of vertical deliveries were not detected. The parameters characterizing the clinical state of the newborns were the same in both groups. The answers given to questionnaires supported the favorable psychological effects of a vertical delivery. The authors hope that vertical delivery, as a possible alternative, will find its place in obstetric practice in Hungary.

[Family-centered obstetrics]. / Családközpontú szülészet.

Family centralised delivery model program in the Department of Obstetrics of Borsod County Hospital in Miskolc is reviewed. This program has been started since 1986. Significance and positive emotional effects are emphasized. Preparation for the birth, the presence of the husband in the labour ward, the alternative delivery position and the rooming-in system are discussed in detail. The natural birth's behaviour, which is very important in the life of the family, would be realized with this program.