1.
Org Biomol Chem
; 20(10): 2109-2114, 2022 03 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35199820
RESUMO
An efficient silver-mediated oxidative trifluoromethylthiolation of unsaturated carboxylic acids to construct trifluoromethylthiol-containing lactones has been disclosed. In this protocol no metal-catalysts was added, and preliminary mechanism investigations suggested that a free-radical pathway should be involved in the process. High functional group tolerance and excellent yields were demonstrated by the efficient preparation of a wide range of γ-trifluoromethylthiolated phthalides.