Clinical Outcomes After Anterior Cruciate Ligament Injury: Panther Symposium ACL Injury Clinical Outcomes Consensus Group.

A stringent outcome assessment is a key aspect of establishing evidence-based clinical guidelines for anterior cruciate ligament (ACL) injury treatment. To establish a standardized assessment of clinical outcome after ACL treatment, a consensus meeting including a multidisciplinary group of ACL experts was held at the ACL Consensus Meeting Panther Symposium, Pittsburgh, Pennsylvania, USA, in June 2019. The aim was to establish a consensus on what data should be reported when conducting an ACL outcome study, what specific outcome measurements should be used, and at what follow-up time those outcomes should be assessed. The group reached consensus on 9 statements by using a modified Delphi method. In general, outcomes after ACL treatment can be divided into 4 robust categories: early adverse events, patient-reported outcomes (PROs), ACL graft failure/recurrent ligament disruption, and clinical measures of knee function and structure. A comprehensive assessment after ACL treatment should aim to provide a complete overview of the treatment result, optimally including the various aspects of outcome categories. For most research questions, a minimum follow-up of 2 years with an optimal follow-up rate of 80% is necessary to achieve a comprehensive assessment. This should include clinical examination, any sustained reinjuries, validated knee-specific PROs, and health-related quality of life questionnaires. In the midterm to long-term follow-up, the presence of osteoarthritis should be evaluated. This consensus paper provides practical guidelines for how the aforementioned entities of outcomes should be reported and suggests the preferred tools for a reliable and valid assessment of outcome after ACL treatment.

Spin canting and metamagnetism in the first hybrid cobalt-hypoxanthine open framework with umr topology.

Hydrothermal reactions generated a cobalt-hypoxanthine framework [Co(3)(OH)(4)(Hpxt)(2)]⋅2H(2)O (H(2) pxt=6-hydroxypurine, 1⋅2H(2)O), which became a microporous framework [Co(3)(OH)(4)(Hpxt)(2)] (1) through a single-crystal-to-single-crystal transformation. Compound 1⋅2H(2)O shows a three-dimensional umr topological structure with two types of spiral channels constructed by rod-shaped {Co(3)(µ-OH)(4)(N-C-N)(2)(N-C-C-O)(2)} second building units (SBUs). The larger channel is filled by fourfold spiral water chains. An unprecedented µ(5)-O6,N3,N7,N9 coordination mode of the Hpxt anion was observed. Both complexes 1⋅2H(2)O and 1 qualitatively show similar metamagnetism from anti-parallel to parallel ferromagnetic cobalt-hydroxide chains. Compared with 1⋅2H(2)O, a smaller Curie constant and more negative Weiss constant in 1 indicate that the helical water chains tend to suppress antiferromagnetic coupling between Co(3)(OH)(4) ferromagnetic chains. Detailed magnetic studies of 1⋅2H(2)O revealed that the competitive interactions between interchain antiferromagnetic exchange coupling and single-ion anisotropy of Co(II) resulted in a partly canted antiferromagnetic sate in low fields. Anti-parallel arrangement of adjacent ferromagnetic chains in middle fields gives 3D antiferromagnetic ordering, and magnetic ground states in high fields are a parallel arrangement of ferromagnetic chains.

Solvent induced molecular magnetic changes observed in single-crystal-to-single-crystal transformation.

Single-crystal-to-single-crystal (SCSC) transformations have recently been found in some molecular magnets, which involve rearrangement or dynamic movement of molecular components of the crystals. Various stimuli such as guest removal, guest exchange, ligand exchange as well as redox reactions may induce SCSC transformations. To date, only a few molecular magnets are known to exhibit SCSC transformations, which often show high-dimensional robust structures. This review mainly focuses on magnetic complexes that are robust enough to experience SCSC transformations and show magnetic changes induced by solvents in due course. This contribution is organized according to the means of solvent treatment of molecular magnets, aiming at revealing magneto-structural correlation in such SCSC transformations.

Cu6S4 cluster based twelve-connected face-centered cubic and Cu19I4S12 cluster based fourteen-connected body-centered cubic topological coordination polymers.

Hydrothermal reaction of Cu(MeCO2)2, (4-pyridylthio)acetic acid and NH4SCN resulted in a twelve-connected face-centered cubic topological metal-organic framework [Cu3(pdt)2(CN)] (pdt = pyridinethiolate) in which Cu6S4 clusters act as twelve-connected nodes and pyridine rings and cyanides act as connectors. As an extension, an unprecedented fourteen-connected body-centered cubic coordination polymer [Cu19I4(pdt)12(SH)3] has been synthesized by three methods, in which nanosized chiral Cu19I4S12 clusters act as fourteen-connected nodes and triple pyridine rings and hydrosulfides act as connectors. The in situ S-C(sp(3)), S-C(sp(2)), and S-C(sp) cleavage reactions have been observed in the work.

Cuprophilicity-induced cocrystallization of [Cu2(4,4'-bpy)(CN)2]n sheets and [Cu(SCN)]n chains into a 3-D pseudopolyrotaxane.

The cocrystallization of [Cu(SCN)]n chains and [Cu2(4,4'-bpy)(CN)2]n (4,4'-bpy = 4,4'-bipyridine) layers generated a 3-D pseudopolyrotaxane compound, [Cu2(4,4'-bpy)(CN)2].[Cu(SCN)] (1), which can also be viewed as a 3-D network constructed by linkages of 2-D sheets and 1-D chains via unsupported CuI-CuI interactions. The CuI-CuI contact of 2.651(4) A in 1 is the shortest unsupported CuI-CuI distance documented to date, indicating cuprophilic attractions.