Effect of right anterolateral thoracotomy versus median sternotomy on postoperative wound tissue repair in patients with congenital heart disease: A meta-analysis.

Right anterolateral thoracotomy (RAT) and median sternotomy (MS) are two major methods for treatment of congenital cardiac disease. But there are various types of surgery that provide a better operative outcome for the patient. Therefore, we carried out a meta-analysis to investigate the effects of these two methods in the treatment of wound tissue, hospitalization and so on, to find out which surgery method could provide the best short-term effect. In this research, we chose an English controlled trial from 2003 to 2022 to evaluate the influence of right anterolateral thoracotomy and median sternotomy on the short-term outcome of Cardiopulmonary bypass (CPB), time of operation, time spent in the hospital, and the time of scar formation. Our findings suggest that the RAT method was associated with a shorter surgical scars for congenital heart disease operations compared to MS with respect to post-operation scars (WMD, 3.55; 95% CI, 0.04, 7.05; p = 0.05). The RAT method is better suited to the needs of patients who care about their injuries. Nevertheless, in addition to other surgery related factors which might affect post-operative wound healing, we discovered that MS took a shorter time to perform CPB compared with RAT surgery (WMD, - 1.94; 95% CI, -3.39, -0.48; p = 0.009). Likewise, when it comes to the time taken to perform surgery, MS needs less operational time compared to RAT methods (WMD, -12.84; 95% CI, -25.27, -0.42; p = 0.04). On the other hand, the time needed for MS to recover was much longer compared to the RAT (WMD, 0. 60; 95% CI, 0.02, 1.18; p = 0.04). This indicates that while RAT is advantageous in terms of shortening the duration of post-operative scar, it also increases the time needed for surgical operations and CPB.

Effect of ABC Theory Model on Negative Emotion of Young Patients with Breast Cancer During Treatment.

Objective: To evaluate the effect of emotional ABC theory on anxiety and depression in young patients with breast cancer. Methods: A total of 200 eligible young patients with breast cancer were randomly divided into control group (N = 100) and experimental group (N = 100). The control group received routine treatment, while the experimental group received emotional ABC theory intervention at the same time. Results: The Self Rating Anxiety Scale (SAS) and Self Rating Depression Scale (SDS) scores of the two groups were observed before and after nursing. There was no significant difference between the two groups before nursing (P > 0.05), but there was significant difference between the two groups after nursing, the control group was significantly higher than the experimental group (P < 0.05). The satisfaction degree of the control group was significantly lower than that of the experimental group (P < 0.05). Conclusion: Young patients with breast cancer using emotional ABC theory can effectively improve negative emotions, clinical can promote the nursing program.

LncRNA MAGI2-AS3-Encoded Polypeptide Restrains the Proliferation and Migration of Breast Cancer Cells.

Accumulating articles have reported the coding potential of long non-coding RNAs (lncRNAs). However, only a few lncRNAs-encoded peptides have been studied. Breast cancer (BRCA) progression-related gene modules were determined by weighted gene co-expression network analysis (WGCNA). Cell viability, proliferation, and migration capacities were assessed by Cell counting kit-8 (CCK8), 5-ethynyl-2'-deoxyuridine (EdU), and transwell assays. Immunofluorescence (IF) assay was implemented to observe protein expression. Co-immunoprecipitation (Co-IP) and high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) were employed to analyze MAGI2 antisense RNA 3 (MAGI2-AS3)-ORF5-interacted proteins. WGCNA identified that MEpurple and MEblack modules were significantly negatively correlated with T stage in BRCA patients. MAGI2-AS3 was screened as one of the differentially expressed (DE) lncRNAs with translational potential in MEblack and MEpurple modules in BRCA. The data in The Cancer Genome Atlas (TCGA) uncovered that MAGI2-AS3 abundance was significantly decreased in invasive BRCA patients, and it had high diagnostic and prognostic values. MAGI2-AS3-ORF5 notably restrained BRCA cell viability, proliferation, and migration. Mechanically, MAGI2-AS3-ORF5 might affect the progression of BRCA cells by binding to extracellular matrix (ECM)-related proteins. MAGI2-AS3-ORF5 played an anti-tumor role by inhibiting BRCA cell viability, proliferation, and migration. MAGI2-AS3-ORF5 might modulate BRCA cell migration through ECM-associated proteins.

Fast time-evolving random polarization beam smoothing for laser-driven inertial confinement fusion.

We propose a random polarization smoothing method for low-coherence laser to obtain focal spot with random polarization that evolves rapidly in sub-picosecond timescales. Random polarization smoothing is realized by a half-aperture wave plate with sufficient thickness. The degree of polarization and polarization evolution of the focal spot are studied theoretically. The calculation results show that random polarization smoothing can make the polarization of focal spot evolve rapidly and randomly in time and space. Experimentally, the polarization of the focal spot of low-coherence laser with random polarization smoothing is measured by a single-shot polarimeter. The measurement results show that the degree of polarization of the focal spot is reduced to 0.22 on average, which proves the effectiveness of random polarization smoothing. The random polarization smoothing technique on low-coherence laser is expected to reduce the laser plasmas instability through its multi-dimensional random evolution properties.

Full-aperture random polarization smoothing for a low-coherence laser facility.

Two new random polarization smoothing methods using full-aperture elements are proposed on low-coherence lasers, one using birefringent wedge and one using flat birefringent plate. By designing the crystal axis direction and wedge angle of the birefringent plates, the methods can selectively introduce time delay and spatial displacement, so as to obtain fast random evolution of transient polarization by utilizing low spatiotemporal coherence of the laser focal field. Both methods avoid the near field discontinuity and can be used under high fluence. The method using birefringent wedge can slightly improve focal spot uniformity, and the method using flat birefringent plate can obtain non-polarization with DOP lower than 2%. Theoretical studies show that the resulting focal polarization evolves rapidly on sub-picosecond timescales and rapidly covers the entire Poincaré sphere. The method using birefringent wedge is achieved in experiment. The results show that the degree of polarization of the focal spot is reduced from 1 to 0.27, which proves the effectiveness of the full-aperture random polarization smoothing. The full-aperture random polarization smoothing can generate a focal field very close to unpolarized thermal light, which is expected to suppress the laser plasmas instability.

Elastic and inelastic collision dynamics between soliton molecules and a single soliton.

Dissipative systems form various self-organized states owing to the abundant attractor structures. The study of the response of different self-organized states under collision perturbation is of great significance for understanding the dissipative nonlinear systems. The collision dynamics of single soliton and soliton molecules can not only assist the stability analysis of attractors, but also reveal the rich physical connotations of soliton interactions. Here, for the first time, the collision processes of single soliton and soliton molecules in different excited states are detected using the dispersive Fourier transform technology. The collision processes include the disintegration and rebuilding of soliton molecules as well as chaotic oscillating evolution, accompanied by the emergence of transition states such as triple binding state, soliton fusion and acceleration. According to whether the soliton molecule can return to its initial excited state, the collisions are classified as elastic and inelastic. The different interaction strength between solitons is an important condition for rebuilding stable soliton molecules. Numerical simulations show that the gain dynamics are the main physical origin of collisions. Our research will stimulate in-depth research on the interaction of self-organized states in nonlinear systems such as chemical molecules, and have potential applications in optical logic gates.

Pretreatment with Methylene Blue Protects Against Acute Seizure and Oxidative Stress in a Kainic Acid-Induced Status Epilepticus Model.

BACKGROUND The aim of the present study was to investigate the potential anticonvulsant effect of methylene blue (MB) in a kainic acid (KA)-induced status epilepticus (SE) model. The effects of MB on levels of oxidative stress and glutamate (Glu) also were explored. MATERIAL AND METHODS Sixty C57BL/6 mice were randomly divided into 5 equal-sized groups: (1) controls; (2) KA; (3) MB 0.5 mg/kg+KA; (4) MB 1 mg/kg+KA; and (5) vehicle+KA. The SE model was established by intra-amygdala microinjection of KA. Behavioral observations and simultaneous electroencephalographic records of the seizures in different groups were analyzed to determine the potential anticonvulsant effect of MB. The influences of MB on oxidative stress markers and glutamate were also detected to explore the possible mechanism. RESULTS MB afforded clear protection against KA-induced acute seizure, as measured by the delayed latency of onset of generalized seizures and SE, decreased percentage of SE, and increased survival rate in mice with acute epilepsy. MB markedly increased the latency to first onset of epileptiform activity and decreased the average duration of epileptiform events, as well as the percentage of time during which the epileptiform activity occurred. Administration of MB prevented KA-induced deterioration of oxidative stress markers and Glu. CONCLUSIONS MB is protective against acute seizure in SE. This beneficial effect may be at least partially related to its potent antioxidant ability and influence on Glu level.

Transient behaviors of pure soliton pulsations and soliton explosion in an L-band normal-dispersion mode-locked fiber laser.

As one of the most striking localized structures in dissipative systems, pulsating soliton has been widely studied in theory but rarely observed in experiments. Here, three typical types of soliton pulsations are experimentally demonstrated in an L-band normal-dispersion mode-locked fiber laser via the dispersive Fourier transform (DFT) technique. According to the distinctive features, they are classified as single-periodic pulsating soliton, double-periodic pulsating soliton and soliton explosion. These pulsations have common features such as energy oscillation, bandwidth breathing and temporal shift. However, the pulse is repeated every two oscillations for double-periodic pulsating soliton. When it comes to soliton explosion, because of the intermittent overdriven nonlinear effect induced by the extreme energy oscillation, the spectrum cracks into pieces at a periodic manner. To the best of our knowledge, it is the first time that both pure soliton pulsations and soliton explosion are observed experimentally in the same fiber laser. The results will enhance a more comprehensive understanding for the soliton pulsating phenomena.

Self-organized compound pattern and pulsation of dissipative solitons in a passively mode-locked fiber laser.

We experimentally observe soliton self-organization and pulsation in a passively mode-locked fiber laser. The optomechanical interaction in the optical fiber is key to the formation of equidistant soliton bunches. These solitons simultaneously undergo a pulsation process with a period corresponding to tens of the cavity round trip time. Using the dispersive Fourier transformation technique, we find that the Kelly sidebands in the shot-to-shot spectra appear periodically, synchronizing with the pulsation.

Dynamic evolution of pulsating solitons in a dissipative system with the gain saturation effect.

We numerically investigate the dynamic evolution of pulsating solitons based on complex cubic-quintic Ginzburg-Landau equation with gain dynamics effects. We show that an additional soliton can be generated by the disturbance caused by a dispersion wave emitted by a single-period pulsating soliton and these solitons form soliton molecule. More complicated oscillating processes, such as snaking pulsation and double-periodic pulsation are actuated by periodic collision of the entangled solitons. Moreover, the dispersive wave, caused by high gain parameters and the soliton collision, appears periodically which is in sync with the pulsating process. These results are consistent with the recent experiments of soliton pulsations measured by dispersive Fourier transform techniques, and will stimulate further experimental research of the complex multi-soliton bunches in dissipative systems.

Q-switched-like soliton bunches and noise-like pulses generation in a partially mode-locked fiber laser.

We report an intermediate regime between c.w. emission and noise-like pulses (NLPs) regime in an Er-doped partially mode-locked fiber laser with nonlinear polarization rotation. In this regime, the soliton bunches stochastically turn up from a quasi-cw background in the Q-switched-like envelope. The soliton bunches normally last for tens or hundreds of intracavity round-trips. When the soliton bunches vanish, typical NLPs chains are generated sporadically at location where the soliton bunches collapses. These results would be helpful to understand the generation and property of the NLPs regime.