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1.
J Clin Virol ; 30(3): 233-8, 2004 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-15135741

RESUMO

BACKGROUND: Rubella virus generally causes a mild fever, rash illness similar in clinical presentation to infections by other viruses including measles and parvovirus B19. Rubella infections in pregnant women in the first trimester carry a high risk of congenital rubella syndrome (CRS) which can result in severe congenital defects in the infants. The goal of rubella immunization programs is therefore to eliminate CRS. The primary test for the laboratory confirmation of rubella is IgM serology. It is therefore important to evaluate currently available commercial rubella IgM immunoassays to ensure high quality rubella diagnostic testing. STUDY DESIGN: In this study, we compared the performance of seven commercial rubella IgM enzyme immunoassays (EIA) (Meddens, Denka Seiken, Behring, Wampole, Captia, Sigma and Abbott Axsym) using well-defined panels of sera from rubella and non-rubella/rash-illness cases. RESULTS: The Meddens, Denka Seiken, Behring and Wampole rubella IgM EIAs all performed similarly for sensitivity (range of 74.1-76.8%) and specificity (range of 93.9-96.1%). Relative to the other assays, the Axsym had a higher sensitivity (78.9%) but lower specificity (86.5%). The Captia assay had the lowest overall sensitivity (66.4%), while the Sigma assay had a lower specificity (85.6%) in relation to the other assays. CONCLUSIONS: In conclusion, the Meddens, Denka Seiken, Behring and Wampole rubella IgM EIAs are comparable in their overall performance with respect to sensitivity and specificity.


Assuntos
Anticorpos Antivirais/sangue , Técnicas Imunoenzimáticas/métodos , Imunoglobulina M/sangue , Kit de Reagentes para Diagnóstico , Rubéola (Sarampo Alemão)/diagnóstico , Humanos , Vírus da Rubéola/imunologia , Sensibilidade e Especificidade
2.
J Clin Microbiol ; 41(10): 4790-2, 2003 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-14532222

RESUMO

We evaluated the performance of three commercial measles immunoglobulin M enzyme immunoassays from Meddens, Denka Seiken, and Behring. The sensitivities were determined to be 96.7% for the Meddens and Denka Seiken assays and 87.9% for the Behring assay. The specificities of the assays were determined to be 94.6% for Meddens, 98.2% for Denka Seiken, and 98.7% for Behring.


Assuntos
Imunoglobulina M/sangue , Vírus do Sarampo/imunologia , Sarampo/diagnóstico , Kit de Reagentes para Diagnóstico , Anticorpos Antivirais/sangue , Humanos , Técnicas Imunoenzimáticas , Valor Preditivo dos Testes , Sensibilidade e Especificidade
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